【摘要】：青光眼是一組具有特征性視神經(jīng)損害及視野缺損,且以視網(wǎng)膜神經(jīng)節(jié)細(xì)胞死亡為病理改變的疾病,是全球最常見的不可逆性致盲眼病。目前有關(guān)視神經(jīng)損害的機(jī)制并不完全清楚,臨床上亦缺乏有效的視神經(jīng)保護(hù)治療方法,尤其缺乏從分子水平提高視網(wǎng)膜神經(jīng)節(jié)細(xì)胞對(duì)抗壓力損害的干預(yù)方式。因此探討視神經(jīng)壓力損傷的分子機(jī)制,比如經(jīng)機(jī)械應(yīng)力信號(hào)通路和炎性反應(yīng)因素引起的視網(wǎng)膜繼發(fā)性損傷機(jī)制等成為本領(lǐng)域研究熱點(diǎn)。本文就上述研究進(jìn)展進(jìn)行綜述。
[Abstract]:Glaucoma is a group of diseases with characteristic optic nerve damage and visual field defect and the death of retinal ganglion cells as the pathological change. Glaucoma is the most common irreversible blindness in the world. At present, the mechanism of optic nerve damage is not completely clear, and there is a lack of effective methods of optic nerve protection in clinic, especially the intervention of increasing retinal ganglion cells against pressure damage at molecular level. Therefore, exploring the molecular mechanism of optic nerve pressure injury, such as the mechanism of secondary retinal injury caused by mechanical stress signal pathway and inflammatory response factors, has become a hot topic in this field. This paper reviews the research progress mentioned above.
【作者單位】： 中南大學(xué)愛爾眼科學(xué)院;首都醫(yī)科大學(xué)附屬北京同仁醫(yī)院北京同仁眼科中心北京市眼科研究所眼科學(xué)與視覺科學(xué)北京市重點(diǎn)實(shí)驗(yàn)室;
【分類號(hào)】：R77

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