【摘要】：目的：觀察血清TK1的濃度在喉癌及不同證型中的相關(guān)性。 方法：于2010.03-2011.12期間按中醫(yī)診斷標(biāo)準(zhǔn)先后收集病理確診喉部鱗狀細(xì)胞癌患者痰熱壅滯型和氣滯血瘀型各15例,共30例喉癌病例作為病例組,另收集30例喉部良性病變組作為對照組,病例組中分為痰熱壅滯型組和氣滯血瘀型組兩組各15例。采用免疫印跡增強(qiáng)化學(xué)發(fā)光法對病例組和對照組進(jìn)行血清中TK1濃度測定。收集各個(gè)實(shí)驗(yàn)對象的TK1濃度值,SPSS16.0進(jìn)行數(shù)據(jù)統(tǒng)計(jì)分析,得出實(shí)驗(yàn)臨床結(jié)果。 結(jié)果：1病例組血清中的TK1濃度2.68(1.18-7.21)pmol/L明顯高于對照組血清中的TKI濃度1.05(0.03-2.50)pmol/L；2.按中醫(yī)辨證喉菌患者氣滯血瘀型血清TK1濃度3.51(1.98-7.21)pmol/L較痰熱壅滯型1.84(1.18-3.88)pmol／高；3.以TK1濃度大于2pmol/L為陽性判斷標(biāo)準(zhǔn),TK1診斷喉癌的靈敏度為60.00%,特異度為93.70%。表明TKI對喉癌診斷具有一定的臨床意義(詳見圖1)。 結(jié)論：血清TK1檢測在喉癌患者及不同證型之間的臨床診斷中具有臨床意義。證實(shí)TK1濃度的檢測對喉部惡性腫瘤診斷有相關(guān)性。
[Abstract]:Objective: to observe the correlation of serum TK 1 concentration in laryngeal carcinoma and different syndromes. Methods: according to traditional Chinese medicine diagnostic criteria, 15 cases of phlegm and heat stagnation type and 15 cases of qi stagnation and blood stasis type were collected from 30 cases of laryngeal carcinoma as case group and 30 cases of benign laryngeal lesions as control group. The patients were divided into two groups: phlegm and heat stagnation group and qi stagnation and blood stasis group. The concentration of TK1 in serum was determined by Western blotting enhanced chemiluminescence assay in the case group and the control group. The TK1 concentration of each experimental object was collected and SPSS 16.0 was collected for statistical analysis, and the clinical results were obtained. Results the serum TK1 concentration in the case of 1: 1 was 2.68 (1.18-7.21) pmol / L significantly higher than that in the control group (1.05 (0.03-2.50) pmol / L ~ (2). According to TCM syndrome differentiation, the serum TK1 concentration of patients with qi stagnation and blood stasis was 3.51 (1.98-7.21) pmol / L higher than that of phlegm-heat stagnation 1.84 (1.18-3.88) pmol/. The sensitivity and specificity of TK1 for the diagnosis of laryngeal carcinoma were 60.00and 93.70 respectively. This indicates that TKI has some clinical significance in the diagnosis of laryngeal carcinoma (see figure 1 for details). Conclusion: the detection of serum TK 1 has clinical significance in the diagnosis of laryngeal cancer patients and different syndromes. It was confirmed that the detection of TK 1 concentration was related to the diagnosis of laryngeal malignant tumor.
【學(xué)位授予單位】：福建中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R273;R739.65

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