【摘要】：目的：探討氧化應(yīng)激在阻塞性睡眠呼吸暫停低通氣綜合征（OSAHS）通過動脈粥樣硬化導(dǎo)致腦梗死發(fā)生中的作用。 方法：按照入排標(biāo)準(zhǔn)選取研究期間住院的腦梗死患者20例、OSAHS患者20例、腦梗死+OSAHS患者20例作為病例組；在體檢中心選取同一時期的健康體檢者20例作為對照組。采用雙抗體夾心ABC-ELISA法測定15-F2t-異前列烷的表達(dá)；采用頸動脈超聲測定頸動脈內(nèi)膜厚度（IMT）。 結(jié)果：（1）15-F2t-異前列烷的表達(dá)和頸動脈內(nèi)膜厚度分別在對照組、腦梗死組、OSAHS組、腦梗死+OSAHS組之間進(jìn)行比較差別有統(tǒng)計學(xué)意義（15-F2t-異前列烷：F=153.142，P0.001；IMT：F=183.056，P0.001）。（2）四組中15-F2t-異前列烷和頸動脈內(nèi)膜厚度行相關(guān)分析顯示在病例組中二者呈正相關(guān)，以腦梗死+OSAHS組相關(guān)性最為明顯（對照組：r=-0.046，P=0.847；腦梗死組：r=0.460，P=0.041；OSAHS組：r=0.482，P=0.032；腦梗死+OSAHS組：r=0.685，P0.001）。 結(jié)論：氧化應(yīng)激程度與頸動脈內(nèi)膜增厚呈直線相關(guān)，在OSAHS合并腦梗死時二者明顯相關(guān)，，推知OSAHS患者的氧化應(yīng)激水平增高可通過誘發(fā)或加重動脈粥樣硬化進(jìn)而導(dǎo)致腦梗死發(fā)生，為臨床中預(yù)防OSAHS患者發(fā)生腦梗死提供理論指導(dǎo)。
[Abstract]:Aim: to investigate the role of oxidative stress in cerebral infarction caused by atherosclerosis in obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: 20 inpatients with OSAHS and 20 patients with OSAHS with cerebral infarction were selected as the case group according to the admission criteria, and 20 healthy persons were selected as the control group in the same period of the physical examination center. The expression of 15-F2t- isoprostaglandin was detected by double antibody sandwich ABC-ELISA, and carotid intima thickness (IMT) was measured by carotid artery ultrasound. Results: (1) the expression of 15-F2t- isoprostaglandin and carotid intima thickness were significantly different between the control group, the cerebral infarction group and the cerebral infarction OSAHS group (15-F2t- isoprostaglandin: 153.142 P 0.001). The correlation analysis of 15-F2t- isoprostaglandin and carotid intimal thickness showed that there was a positive correlation between 15 F2t- isoprostaglandin and carotid intimal thickness in four groups, especially in cerebral infarction OSAHS group (control group: 0. 046% P0. 847; cerebral infarction group: R0. 460P0. 041 OSAHS group: 0. 482P = 0. 032; cerebral infarction group: 0. 460P0. 041OSAHS group: 0. 482P0. 032; cerebral infarction group: 0. 460P0.041OSAHS group: 0. 482P0. 032) Cerebral infarction OSAHS group: 0. 685% P 0.001). Conclusion: the degree of oxidative stress is linearly correlated with carotid intima thickening, which is significantly correlated with OSAHS with cerebral infarction. It is inferred that the increase of oxidative stress level in OSAHS patients may lead to cerebral infarction by inducing or exacerbating atherosclerosis. To provide theoretical guidance for the prevention of cerebral infarction in patients with OSAHS.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R766

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