【摘要】：目的探討普拉洛芬滴眼液不同用藥時(shí)間對(duì)干眼癥療效的影響。方法選取我院眼科門診診斷為雙眼干眼癥的患者117例,按照隨機(jī)數(shù)字表法將患者分成普拉洛芬14 d組(39例)、普拉洛芬30 d組(40例)和對(duì)照組(38例)。普拉洛芬14 d組給予1 g·L~(-1)普拉洛芬滴眼液(14 d)聯(lián)合1 g·L~(-1)玻璃酸鈉滴眼液(30 d);普拉洛芬30 d組給予1 g·L~(-1)普拉洛芬滴眼液(30 d)聯(lián)合1 g·L~(-1)玻璃酸鈉滴眼液(30 d),對(duì)照組僅給予1 g·L~(-1)玻璃酸鈉滴眼液(30 d)。給藥方法均為局部滴雙眼,每次1滴,每天4次。分別于治療前后檢測(cè)3組患者的淚液分泌試驗(yàn)I(Schirmer I test,SIt)、淚膜破裂時(shí)間(tear break-up time,BUT)和角膜熒光素染色(corneal fluorescent staining,FL)評(píng)分。結(jié)果治療前3組患者人口基線特征比較差異均無統(tǒng)計(jì)學(xué)意義(均為P0.05)。治療后普拉洛芬14 d組SIt(7.11±1.36)mm和BUT(8.42±0.79)s均高于對(duì)照組SIt(5.19±0.85)mm和BUT(5.92±1.24)s;FL評(píng)分(0.73±0.72)顯著低于對(duì)照組(1.88±0.71),差異均有統(tǒng)計(jì)學(xué)意義(tSIt=8.000,P0.001;tBUT=10.870,P0.001;tFL=-7.667,P0.001);治療后普拉洛芬30 d組SIt(7.38±1.01)mm和BUT(8.12±1.00)s均高于對(duì)照組,FL評(píng)分(0.88±0.68)顯著低于對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(tSIt=9.125,P0.001;tBUT=9.565,P0.001;tFL=-6.667,P0.001);但治療后普拉洛芬14 d組與普拉洛芬30 d組的SIt、BUT和FL評(píng)分差異均無統(tǒng)計(jì)學(xué)意義(tSIt=~(-1).125,0.4P0.2;tBUT=1.304,0.2P0.1;tFL=~(-1).000,0.4P0.2)。結(jié)論短期應(yīng)用1 g·L~(-1)普拉洛芬滴眼液治療干眼癥即可達(dá)到較好的療效,它是輔助治療干眼癥的有效藥物。
[Abstract]:Objective to investigate the effect of Praprofen eye drops on dry eye. Methods 117 patients diagnosed as binocular xerophthalmia were randomly divided into three groups: Praprofen 14-day group (39 cases), Praprofen 30-day group (40 cases) and control group (38 cases). 1 g L ~ (-1) Praprofen eye drops (14 d) combined with 1 g L ~ (-1) sodium hyaluronate eye drops (30 d);) Praprofen eye drops (30 d) combined with 1 g L ~ (-1) sodium hyaluronate eye drops (30 d), control group) 1 g L ~ (-1) sodium hyaluronate eye drops (30 d).) The methods of administration were local drops of both eyes, 1 drop each time, 4 times a day. The tear secretion test I (Schirmer I test), tear break-up time of rupture (tear break-up timebut) and corneal fluorescein staining (corneal fluorescent staining) were measured before and after treatment. Results there was no significant difference in population baseline characteristics between the three groups before treatment (P0.05). 娌葷枟鍚庢櫘鎷夋礇鑺，

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