本文選題：病毒 + 慢性扁桃體炎�。� 參考：《臨床耳鼻咽喉頭頸外科雜志》2017年14期

【摘要】：目的:探索非急性感染期間,腺樣體和扁桃體組織中EB病毒(EBV)、人博卡病毒(HBoV)及多瘤病毒KI和WU(KIPyV和WUPyV)檢測(cè)的檢出率以及4種病毒的季節(jié)性分布特征。方法:采用實(shí)時(shí)聚合酶鏈反應(yīng)檢測(cè)慢性扁桃體炎和腺體肥大兒童中EBV,HBoV,多瘤病毒KIPyV和WUPyV的DNA表達(dá)。患者分組如下:腺樣體肥大組,慢性扁桃體炎組和生理性扁桃體肥大組。還研究了這些病毒的表達(dá)與年齡,性別,反復(fù)感染和氣道阻塞的關(guān)系。此外,還分析了這些病毒在腺樣體和扁桃體組織中的檢測(cè)率的季節(jié)變化。結(jié)果:研究發(fā)現(xiàn),HBoV是腺樣體標(biāo)本中最常見的病毒,檢出率為43.1%。在慢性扁桃體炎和扁桃體肥大標(biāo)本中,EBV是最常見的病毒(檢出率分別為53.8%和32.0%)。雖然在腺樣體肥大組的兒童中全年都能檢測(cè)到HBoV和EBV陽性,但在慢性扁桃體炎的兒童中全年也均能檢測(cè)到EBV陽性。結(jié)論:在無癥狀慢性扁桃體炎及腺樣體肥大兒童樣本中全年都能檢測(cè)到HBoV和EBV,這表明這些病毒可能持續(xù)存在于上呼吸道的淋巴上皮組織中。病毒持久性存在可能對(duì)淋巴樣肥大的發(fā)展有致病潛力,并對(duì)炎癥有慢性刺激作用。
[Abstract]:Objective: to investigate the detection rate of Epstein-Barr virus (EBV), human Boca virus (HBoV) and polytumour virus (Ki and WUPyV) in adenoid and tonsil tissues during non-acute infection. Methods: real-time polymerase chain reaction was used to detect the DNA expression of EBV HBoV, polytumour virus KIPyV and WUPyV in children with chronic tonsillitis and hypertrophy. Patients were divided as follows: adenoid hypertrophy group, chronic tonsillitis group and physiologic tonsil hypertrophy group. The relationship between the expression of these viruses and age, sex, recurrent infection and airway obstruction was also studied. In addition, seasonal changes in the detection rates of these viruses in adenoids and tonsils were analyzed. Results: HBoV was the most common virus in adenoid specimens, and the detection rate was 43.1%. EBV was the most common virus in chronic tonsillitis and tonsil hypertrophy (53.8% and 32.0%, respectively). Although HBoV and EBV were detected all year round in children with adenoid hypertrophy, EBV positive was also detected in children with chronic tonsillitis. Conclusion: HBoV and EBV were detected throughout the year in children with asymptomatic chronic tonsillitis and adenoid hypertrophy, suggesting that these viruses may persist in upper respiratory tract lymphoid epithelium. Persistence of the virus may have pathogenicity in the development of lymphoid hypertrophy and chronic irritation to inflammation.
【作者單位】： 陽新縣中醫(yī)醫(yī)院耳鼻咽喉科;武漢大學(xué)中南醫(yī)院耳鼻咽喉科;
【分類號(hào)】：R766

【參考文獻(xiàn)】

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1 唐媛媛;劉剛;王吉U，

本文編號(hào)：2115224