本文選題：角膜共焦激光顯微鏡 + 角膜神經(jīng)�。� 參考：《眼科新進(jìn)展》2017年09期

【摘要】：目的探討角膜共焦激光顯微鏡檢測(cè)的角膜基底神經(jīng)變化與2型糖尿病(type 2 diabetes mellitus,T2DM)視網(wǎng)膜微血管病變的相關(guān)性。方法選取2016年2月至2017年2月在我院治療的T2DM患者118例,其中合并糖尿病視網(wǎng)膜病變(diabetic retinopathy,DR)患者57例(DR組),無(wú)DR患者61例(NDR組),同時(shí)選取健康志愿者60人作為對(duì)照組,所有研究對(duì)象采用角膜共焦激光顯微鏡檢查,分析角膜神經(jīng)形態(tài)參數(shù)與臨床指標(biāo)的關(guān)系。結(jié)果 DR組角膜神經(jīng)纖維密度、角膜神經(jīng)分支密度和角膜神經(jīng)長(zhǎng)度分別為(20.03±4.22)條·mm-2、(22.01±7.05)條·mm-2和(9.50±1.76)mm·mm-2,明顯小于對(duì)照組和NDR組(均為P0.05),而角膜神經(jīng)纖維彎曲度為0.30±0.03,明顯高于對(duì)照組和NDR組(均為P0.05);DR患者中,Ⅲ期患者角膜神經(jīng)纖維密度、角膜神經(jīng)分支密度和角膜神經(jīng)長(zhǎng)度明顯小于Ⅰ期和Ⅱ期DR患者(均為P0.05),而角膜神經(jīng)纖維彎曲度明顯高于Ⅰ期和Ⅱ期DR患者(均為P0.05)。DR組病程為(12.04±2.48)a,明顯高于NDR組(P0.05),而空腹C肽和空腹胰島素分別為(1.41±0.58)μg·L-1和(20.05±7.91)m U·L-1,明顯低于NDR組(均為P0.05)。T2DM患者病程與角膜神經(jīng)分支密度及角膜神經(jīng)纖維長(zhǎng)度呈負(fù)相關(guān)(r=-0.322、-0.317,均為P0.05);空腹C肽與角膜神經(jīng)分支密度呈正相關(guān)(r=0.298,P0.05),與角膜神經(jīng)彎曲度呈負(fù)相關(guān)(r=-0.311,P0.05)。結(jié)論 T2DM視網(wǎng)膜微血管病變患者角膜神經(jīng)形態(tài)參數(shù)異常,對(duì)病程較長(zhǎng)或空腹C肽水平低的T2DM患者應(yīng)用角膜共激光顯微鏡檢測(cè)有助于早期發(fā)現(xiàn)微血管病變。
[Abstract]:Objective to investigate the correlation between corneal basal nerve changes and type 2 diabetes mellitus (type 2 diabetes mellitus T2DM) by confocal laser microscopy. Methods from February 2016 to February 2017, 118 patients with T2DM were selected, including 57 patients with diabetic retinopathy Dr (Dr group), 61 patients without Dr (NDRgroup), and 60 healthy volunteers as control group. Corneal confocal laser microscopy was used to analyze the relationship between corneal nerve morphology and clinical parameters. Results the density of corneal nerve fibers in Dr group, The corneal nerve branching density and corneal nerve length were (20.03 鹵4.22) mm ~ (-2), (22.01 鹵7.05) mm-2 and (9.50 鹵1.76) mm m ~ (-2), respectively, which were significantly lower than those in the control group and the mm-2 group (P0.05), while the corneal nerve fiber curvature was 0.30 鹵0.03, which was significantly higher than that in the control group and the mm-2 group (P0.05). The density of corneal nerve fibers in stage 鈪，

本文編號(hào)：2103435