本文選題：阻塞性睡眠呼吸暫停低通氣 + 經(jīng)鼻持續(xù)氣道正壓通氣�。� 參考：《廣東醫(yī)學(xué)》2017年S2期

【摘要】：目的探討經(jīng)鼻持續(xù)氣道正壓通氣(nCPAP)治療對(duì)重度阻塞性睡眠呼吸暫停低通氣綜合征(OSAHS)患者血液流變及同型半胱氨酸(Hcy)水平的影響。方法選取經(jīng)多導(dǎo)睡眠監(jiān)測(cè)儀診斷的32例重度OSAHS患者(觀察組),隨機(jī)選擇同期20例經(jīng)多導(dǎo)睡眠監(jiān)測(cè)儀排除OSAHS的健康者作為對(duì)照組。檢測(cè)觀察組患者于nCPAP治療前及對(duì)照組的全血黏度、紅細(xì)胞聚集指數(shù)、紅細(xì)胞電泳時(shí)間等血液流變參數(shù)及Hcy水平,進(jìn)行3個(gè)月的nCPAP治療后,再次檢測(cè)血液流變參數(shù)及Hcy水平,觀察nCPAP治療后OSAHS患者血液流變參數(shù)及Hcy水平的變化。結(jié)果觀察組患者全血黏度、紅細(xì)胞聚集指數(shù)、紅細(xì)胞電泳時(shí)間及血清Hcy水平均高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。經(jīng)3個(gè)月nCPAP治療后,觀察組患者全血黏度、紅細(xì)胞聚集指數(shù)、紅細(xì)胞電泳時(shí)間及血清Hcy水平均較治療前明顯下降,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論重度OSAHS患者存在血液流變異常以及血清Hcy水平升高。nCPAP治療可改善重度OSAHS患者血液流變異常,降低其血清Hcy水平,可能有助于降低OSAHS并發(fā)心血管疾病的風(fēng)險(xiǎn)。
[Abstract]:Objective to investigate the effects of nasal continuous positive airway pressure (nCPAP) on hemorheology and homocysteine (Hcy) levels in patients with severe obstructive sleep apnea hypopnea syndrome (OSAHS). Methods 32 patients with severe OSAHS diagnosed by polysomnography (observation group) and 20 healthy persons excluded from OSAHS by polysomnography were randomly selected as control group. The hemorheological parameters such as whole blood viscosity, erythrocyte aggregation index, erythrocyte electrophoresis time and Hcy level were measured before nCPAP treatment and in control group. After 3 months of nCPAP treatment, the hemorheological parameters and Hcy level were measured again. To observe the changes of hemorheological parameters and Hcy level in OSAHS patients after nCPAP treatment. Results the whole blood viscosity, erythrocyte aggregation index, erythrocyte electrophoresis time and serum Hcy level in the observation group were significantly higher than those in the control group (P0.05). After 3 months of nCPAP treatment, the whole blood viscosity, erythrocyte aggregation index, erythrocyte electrophoresis time and serum Hcy level in the observation group were significantly lower than those before treatment (P0.05). Conclusion Hemorheological abnormality and elevated serum Hcy level in patients with severe OSAHS. NCPAP can improve hemorheological abnormalities and decrease serum Hcy levels in patients with severe OSAHS and may help to reduce the risk of OSAHS complicated with cardiovascular disease.
【作者單位】： 佛山市第二人民醫(yī)院呼吸內(nèi)科;佛山市第二人民醫(yī)院檢驗(yàn)科;
【基金】：佛山市醫(yī)學(xué)類科技攻關(guān)項(xiàng)目(編號(hào):2014AB00350)
【分類號(hào)】：R766

【相似文獻(xiàn)】

相關(guān)期刊論文 前3條

1 馬春梅;劉惠亮;韓瑋;羅建平;賈德靜;;阻塞性睡眠呼吸暫停綜合征患者nCPAP治療前后左室結(jié)構(gòu)及舒張功能的變化[J];第四軍醫(yī)大學(xué)學(xué)報(bào);2008年17期

2 薛金鳳,于英杰,孫玉婷;nCPAP治療睡眠呼吸暫停綜合征并急性腦梗死療效分析[J];中國(guó)現(xiàn)代醫(yī)學(xué)雜志;2004年20期

3 楊朝;張群慧;張錦;;OSAHS患者nCPAP治療前后血管活性物質(zhì)變化與血壓的關(guān)系[J];山東醫(yī)藥;2007年31期

相關(guān)會(huì)議論文 前2條

1 張丙芳;黃穎;張琦;鄧小玲;王曉明;黃晨;;老年睡眠呼吸暫停綜合征患者血壓與血管活性物質(zhì)的變化及nCPAP治療的效果[A];全國(guó)睡眠呼吸障礙學(xué)術(shù)會(huì)議論文集[C];2007年

2 李丹;;nCPAP治療對(duì)OSAHS合并EMBPS高血壓患者血壓與腦鈉肽影響[A];中華醫(yī)學(xué)會(huì)第九次全國(guó)老年醫(yī)學(xué)學(xué)術(shù)會(huì)議暨第三屆全國(guó)老年動(dòng)脈硬化與周圍血管疾病專題研討會(huì)論文匯編[C];2009年

相關(guān)碩士學(xué)位論文 前3條

1 張伯之;短期nCPAP治療對(duì)阻塞性睡眠呼吸暫停低通氣綜合征患者血清IL-6的影響[D];天津醫(yī)科大學(xué);2008年

2 李丹;nCPAP治療對(duì)OSAHS合并EMBPS高血壓患者血壓與腦鈉肽影響[D];中南大學(xué);2008年

3 羅斌彬;nCPAP治療對(duì)于重度阻塞性睡眠呼吸暫停低通氣患者心臟舒縮功能影響[D];寧波大學(xué);2014年

，

本文編號(hào)：2096740