本文選題：鼻炎 + 變應(yīng)性��； 參考：《中國耳鼻咽喉頭頸外科》2012年01期

【摘要】：目的探討胸腺調(diào)節(jié)趨化因子(thymus andactivation regulated chemokine,TARC)及嗜酸性粒細(xì)胞趨化因子-2(Eotaxin-2)在變應(yīng)性鼻炎(AR)患者血清中的表達(dá)水平及其在AR發(fā)病機制中的作用及臨床意義。方法應(yīng)用酶聯(lián)免疫吸附實驗法檢測64例AR患者和16例非變應(yīng)性鼻炎(non-allergic rhinitis,NAR)患者外周血中TARC及Eotaxin-2水平。結(jié)果①AR患者血清中TARC及Eotaxin-2光密度(optical density,OD)均值分別為0.476±0.038、2.661±0.902,與NAR組比較OD均值為0.425±0.030、1.055±0.33,差異有統(tǒng)計學(xué)意義(t=5.309、2.731,P0.05)。②輕度持續(xù)性AR患者與中重度持續(xù)性AR患者血清中TARC OD均值分別為0.450±0.035、0.490±0.015,兩組比較,差異無統(tǒng)計學(xué)意義(t=1.500,P=0.011),而與NAR組比較,差異有統(tǒng)計學(xué)意義(t=2.100、3.080,P=0.010)。③輕度持續(xù)性AR患者與中重度持續(xù)性AR患者血清中Eotaxin-2 OD均值分別為2.660±0.900、3.13±1.375,兩組比較,差異無統(tǒng)計學(xué)意義(t=1.618,P=0.032),而與NAR組比較,差異有統(tǒng)計學(xué)意義(t=6.874、5.900,P=0.034)。④AR患者血清中TARC與Eotaxin-2表達(dá)呈明顯正相關(guān)(r=0.880,P0.01)。結(jié)論 TARC及Eotaxin-2在輕度持續(xù)性AR及中重度持續(xù)性AR患者血清中明顯升高,二者呈正相關(guān),可能因TH2反應(yīng)導(dǎo)致AR的發(fā)生,但其增高水平與臨床癥狀嚴(yán)重程度無明顯相關(guān)性。
[Abstract]:Objective to investigate the expression of thymus regulatory chemokine (thymus andactivation regulated chemokine) and eotaxin-2 (eotaxin-2) in the serum of patients with allergic rhinitis (AR) and its role in the pathogenesis of AR and its clinical significance. Methods Enzyme-linked immunosorbent assay (Elisa) was used to detect the levels of TARC and eotaxin-2 in peripheral blood of 64 patients with AR and 16 patients with non-allergic rhinitis NAR. Results 1the OD values of TARC and eotaxin-2 optical density in patients with AR were 0.476 鹵0.038 鹵2.661 鹵0.902, 0.425 鹵0.030 鹵1.055 鹵0.33, respectively. The difference was statistically significant (t 5.309 鹵2.731P0.05). 2 the mean value of serum OD of patients with mild persistent AR and moderate and severe persistent AR was 0.450 鹵0.0350.490 鹵0.015, respectively. There was no significant difference between the two groups (t = 1.500), but there was a significant difference compared with the NAR group (t = 2.100 / 3.080). 3 the mean value of eotaxin-2 OD _ 2 in patients with mild persistent AR and moderate and severe persistent AR was 2.660 鹵0.900 ~ 3.13 鹵1.375, respectively. There was no significant difference between the two groups (t1.618p _ (0.032), but there was no significant difference between the two groups (t _ (1.618) P _ (0.032), and the mean value of eotaxin-2 in patients with moderate and severe persistent AR was 2.660 鹵0.900 ~ 3.13 鹵1.375, respectively. There was a significant positive correlation between the expression of TARC and Eotaxin-2 in patients with AR (r = 0.880, P 0.01). Conclusion TARC and Eotaxin-2 were significantly increased in patients with mild persistent AR and moderate and severe persistent AR. There was a positive correlation between TARC and Eotaxin-2, which might be caused by TH2 reaction, but there was no significant correlation between the elevated level of TARC and Eotaxin-2 and the severity of clinical symptoms.
【作者單位】： 吉林大學(xué)第二醫(yī)院耳鼻咽喉頭頸外科;青島大學(xué)醫(yī)學(xué)院附屬煙臺毓璜頂醫(yī)院耳鼻咽喉頭頸外科;吉林大學(xué)中日聯(lián)誼醫(yī)院耳鼻咽喉頭頸外科;
【分類號】：R765.21

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