本文選題：Graves眼病 + 激素沖擊��； 參考：《現(xiàn)代生物醫(yī)學(xué)進展》2016年24期

【摘要】：目的:探討激素沖擊治療聯(lián)合放療用于中重度Graves眼病的臨床療效。方法:將2014年2月~2015年6月之間我院收治的109例中重度Graves眼病患者隨機分為A組(n=37)、B組(n=35)、C組(n=37)。A組患者單純采用抗甲狀腺藥物治療,B組患者則在A組的基礎(chǔ)上進行激素沖擊治療,C組患者則采用B組基礎(chǔ)上聯(lián)合球后放療方案治療,所有患者治療后保持隨訪至少6個月,對比三組療效,記錄三組患者治療前、治療6個月時的臨床活動評分(CAS)及眼球突出度,及隨訪期間不良反應(yīng)情況。結(jié)果:三組有效率比較,C組B組A組,差異有統(tǒng)計學(xué)意義(P0.05)。治療后三組CAS評分均顯著優(yōu)于治療前(P0.05),且C組顯著低于A、B組(P0.05),A、B組間比較無顯著差異(P0.05)。治療后B、C組眼球突出度顯著低于治療前(P0.05),且C組顯著低于A、B組(P0.05)。A、B、C三組不良反應(yīng)發(fā)生率分別為0、14.29%、5.41%,A、C組比較無顯著差異(P0.05),B組不良反應(yīng)發(fā)生率明顯高于A、C組(P0.05)。結(jié)論:激素沖擊聯(lián)合放療治療中重度Graves眼病具有顯著的療效,能夠有效降低患者的CAS評分及眼球突出度,效果明顯優(yōu)于單純抗甲狀腺治療或激素沖擊治療,且安全性較好,值得在臨床上推廣和應(yīng)用。
[Abstract]:Objective: to investigate the clinical effect of hormone shock therapy combined with radiotherapy for moderate and severe Graves ophthalmopathy. Methods: from February 2014 to June 2015, 109 patients with moderate and severe Graves ophthalmopathy in our hospital were randomly divided into two groups: group A, group B, group A, group B patients treated with antithyroid drugs only, and group B patients treated with antithyroid drugs, on the basis of group A, the patients in group B were treated with antithyroid drugs. The patients in group C were treated with group B combined with Retrobulbar radiotherapy. All patients were followed up for at least 6 months to compare the efficacy of the three groups. The clinical activity score (CAS) and the degree of exophthalmos were recorded before and after treatment in the three groups, and the adverse reactions during the follow-up period were also recorded. Results: the effective rate of three groups was higher than that of C group B group A, the difference was statistically significant (P 0.05). After treatment, the CAS scores in the three groups were significantly better than those in the pre-treatment group (P 0.05), and the scores in group C were significantly lower than those in group A (P 0.05) and there was no significant difference between the two groups (P 0.05). After treatment, the degree of exophthalmos in group B was significantly lower than that in group B (P 0.05), and the incidence of adverse reactions in group C was significantly lower than that in group A (P 0.05). The incidence of adverse reactions in group C was significantly higher than that in group A (P 0.05). Conclusion: hormone shock combined with radiotherapy is effective in treating moderate and severe Graves' ophthalmopathy. It can effectively reduce CAS score and eyeball exophthalmos of patients with Graves' ophthalmopathy. The effect is obviously better than that of antithyroid therapy or hormone shock therapy, and the safety is good. It is worth popularizing and applying in clinic.
【作者單位】： 濟寧市第一人民醫(yī)院內(nèi)分泌科;
【分類號】：R771.3;R581
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本文編號：2033487