本文選題：糖尿病性視網(wǎng)膜病變 + VEGFC��； 參考：《新疆醫(yī)科大學》2017年碩士論文

【摘要】：目的:探討血管內(nèi)皮生長因子(VEGFC及VEGFA)基因多態(tài)性與新疆維吾爾族人群糖尿病性視網(wǎng)膜病變(DR)的關系。方法:333例無糖尿病(NC)患者、164例無糖尿病性視網(wǎng)膜病變(NDR)的糖尿病患者和66例非增殖期糖尿病性視網(wǎng)膜病變(NPDR)患者、72例增殖期糖尿病性視網(wǎng)膜病變(PDR)患者;應用im LDRTM基因分型技術對3個VEGFC基因位點(rs17697419,rs17697515,rs2333526)和5個VEGFA基因位點(rs3025021,rs10434,rs833061,rs2010963,rs699947)進行基因分型。結(jié)果:VEGFC和VEGFC基因中的多個單核苷酸位點多態(tài)性(single nucleotide polymorphisms,SNPs)與PDR相關。rs17697419位點的G/A基因型(P=0.019)和A等位基因(p=0.021),rs2010963的C/C基因型(p=0.017)和C等位基因(p=0.039),rs699947位點的A/A基因型(P=0.028)和A等位基因(P=0.041),rs3025021的T/T基因型(P=0.019)和T等位基因(P=0.038),rs833061的C/C基因型(P=0.028)和C等位基因(P=0.021)與PDR相關。使用Haploview軟件進行單倍型分析,VEGFA位點的5個SNP位點組成頻率1%的單倍型總共11種;在VEGFC位點的3個SNP位點組成頻率1%的單倍型有3種。單倍型ACG(38.3%),CTC(32.7%)和CTG(28.8)是從VEGFC獲得的三個最多的單倍型。單倍型GCC(93.7%)是VEGFA最多的單倍型。結(jié)論:VEGFC與VEGFA單核苷酸多態(tài)性或許與PDR的發(fā)生相關。
[Abstract]:Objective: to investigate the relationship between the polymorphism of vascular endothelial growth factor (VEGF) VEGFC and VEGF gene and diabetic retinopathy (DRV) in Xinjiang Uygur population. Methods Sixty-four patients with nondiabetic retinopathy (NDR) and 66 patients with nonproliferative diabetic retinopathy (NPDRR) without diabetic retinopathy were enrolled in this study. 72 patients with proliferative diabetic retinopathy (PDR) were included in the study. Three VEGFC loci, rs17697515, rs2333526) and five VEGFA loci, rs3025021, rs104334, rs833061, rs2010963rs699947, were genotyped by im LDRTM genotyping. Results multiple single nucleotide polymorphisms (SNPs) in the 1: VEGFC and VEGFC genes were associated with PDR.rs17697419 (P / 0.019) and A allele (p0.021 / rs2010963 / C / p0.017) and C allele (p0.039 / rs699947 / Ar / A / P0.028), respectively. The T / T genotype (P0. 019), the T allele (P0. 038) of rs833061 (P0. 028) and the C allele (P0. 021) of rs3025021) were associated with PDR. Haploview software was used to analyze the haplotypes of 5 SNP loci in VEGFA loci. There were 11 haplotypes with 1% SNP frequencies and 3 haplotypes with 1% SNP frequencies in VEGFC loci. Haplotype ACG 38.3) and CTG 28. 8) are the three most abundant haplotypes obtained from VEGFC. Haplotype GCC 93. 7) is the most haplotype of VEGFA. Conclusion the single nucleotide polymorphisms of VEGFC and VEGFA may be associated with the occurrence of PDR.
【學位授予單位】：新疆醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R587.2;R774.1

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