本文選題：水楊酸鈉 + 耳鳴　； 參考：《中華耳科學(xué)雜志》2016年02期

【摘要】：目的探討聽(tīng)覺(jué)中樞核團(tuán)下丘內(nèi)多巴胺水平的變化在耳鳴發(fā)病機(jī)制中的作用。方法在水楊酸鈉誘導(dǎo)建立的耳鳴動(dòng)物模型基礎(chǔ)上,利用微透析技術(shù)結(jié)合高效液相電化學(xué)檢測(cè)方法,活體、動(dòng)態(tài)研究水楊酸鈉作用后大鼠下丘內(nèi)多巴胺水平的變化。結(jié)果水楊酸鈉引起大鼠下丘多巴胺水平顯著性地降低。大約3小時(shí)后下丘內(nèi)多巴胺水平降至最低,達(dá)到基礎(chǔ)值的49±9%,然后緩慢的升高,大約5小時(shí)后恢復(fù)到基線水平。生理鹽水對(duì)照組未引起任何明顯的變化。結(jié)論大鼠下丘內(nèi)多巴胺水平的顯著性降低可能與水楊酸鈉誘導(dǎo)的耳鳴產(chǎn)生有關(guān),這些活體數(shù)據(jù)為多巴胺這一調(diào)節(jié)人們精神活動(dòng)的重要遞質(zhì)參與耳鳴的發(fā)生提供直接的實(shí)驗(yàn)證據(jù)。
[Abstract]:Objective to investigate the role of dopamine level in inferior colliculus of auditory central nucleus in the pathogenesis of tinnitus. Methods on the basis of the animal model of tinnitus induced by sodium salicylate, the changes of dopamine levels in inferior colliculus of rats after sodium salicylate were studied in vivo by microdialysis and high performance liquid electrochemical detection. Results Sodium salicylate induced a significant decrease in dopamine levels in the inferior colliculus of rats. After about 3 hours, the dopamine level in the inferior colliculus decreased to the lowest, reaching 49 鹵9 of the base value, then slowly increased, and recovered to the baseline level after about 5 hours. Normal saline control group did not cause any significant changes. Conclusion the significant decrease of dopamine level in the inferior colliculus of rats may be related to the production of tinnitus induced by sodium salicylate. These living data provide direct experimental evidence that dopamine, an important neurotransmitter regulating mental activity, is involved in the occurrence of tinnitus.
【作者單位】： 北京大學(xué)第三醫(yī)院耳鼻咽喉科;華信醫(yī)院急診科;中國(guó)科學(xué)院化學(xué)研究所;
【基金】：國(guó)家自然科學(xué)基金項(xiàng)目(30500556、21372020) 北京市自然科學(xué)基金項(xiàng)目(7082100、7112144)聯(lián)合資助~~
【分類號(hào)】：R764.45
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本文編號(hào)：1932220