本文選題：干眼癥 + 普拉洛芬滴眼液��； 參考：《今日藥學(xué)》2016年07期

【摘要】：目的比較0.1%普拉洛芬滴眼液和0.1%氟米龍滴眼液治療中重度干眼癥的療效。方法前瞻性隨機對照研究。對中重度干眼癥的患者共21人39只眼隨機分配成2組:試驗組11人20只眼,給予0.1%普拉洛芬滴眼液和0.1%玻璃酸鈉滴眼液聯(lián)合用藥;對照組10人19只眼使用0.1%氟米龍滴眼液和0.1%玻璃酸鈉滴眼液。用藥前、用藥7 d時分別進(jìn)行主觀問卷調(diào)查和淚膜破裂時間(BUT)檢測。結(jié)果試驗組和對照組年齡及性別構(gòu)成無統(tǒng)計學(xué)意義(P0.05)。試驗組和對照組用藥前平均BUT分別為(2.30±0.92)s、(2.21±0.97)s,2組用藥前平均BUT差別無統(tǒng)計學(xué)意義(t=0.294,P=0.77)。用藥1周后試驗組和對照組的平均BUT分別為(5.25±2.95)s、(2.63±1.54)s,2組用藥后1周平均BUT差別有統(tǒng)計學(xué)意義(P=0.002)。試驗組和對照組治療前后的BUT變化幅度有統(tǒng)計學(xué)差別(F=13.76,P=0.001),試驗組用藥1周的BUT上升幅度明顯大于對照組。2組患者用藥前和用藥后1周的主觀問卷調(diào)查分值無統(tǒng)計學(xué)差異。結(jié)論 0.1%普拉洛芬滴眼液聯(lián)合0.1%玻璃酸鈉滴眼液組治療中重度干眼癥的早期療效顯著,優(yōu)于0.1%氟米龍滴眼液聯(lián)合0.1%玻璃酸鈉滴眼液。
[Abstract]:Objective to compare the efficacy of 0.1% Praprofen eye drops and 0.1% flumilon eye drops in the treatment of moderate and severe xerophthalmia. Methods A prospective randomized controlled study was conducted. Twenty-one patients (39 eyes) with moderate and severe xerophthalmia were randomly divided into two groups: the experimental group (n = 11, n = 20) was treated with 0.1% Praprofen eye drops and 0.1% sodium hyaluronate eye drops; The control group was treated with 0.1% flumilon eye drops and 0.1% sodium hyaluronate eye drops. Before and 7 days after administration, subjective questionnaire and tear film rupture time were measured. Results there was no significant difference in age and sex composition between the experimental group and the control group (P 0.05). The average BUT of the test group and the control group was 2.30 鹵0.92 BUT before the treatment, respectively. There was no significant difference in the average BUT between the two groups before the treatment. There was no significant difference between the two groups. The average BUT of the test group and the control group were 5.25 鹵2.95 BUT and 2.63 鹵1.54 BUT respectively after one week of administration. There was significant difference in the average BUT between the two groups. There was significant difference in the range of BUT between the experimental group and the control group before and after treatment. The increase of BUT in the test group was significantly higher than that in the control group before and after 1 week treatment. There was no significant difference in the score of subjective questionnaire survey between the two groups. Conclusion 0.1% Praprofen eye drops combined with 0.1% sodium hyaluronate eye drops have significant early therapeutic effect on moderate and severe xerophthalmia, which is superior to 0.1% flumilon eye drops combined with 0.1% sodium hyaluronate eye drops.
【作者單位】： 汕頭大學(xué).香港中文大學(xué)聯(lián)合汕頭國際眼科中心;
【基金】：廣東省臨床用藥研究基金(2015RL11)
【分類號】：R777.34

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