本文選題：胎盤生長因子 + 血管內(nèi)皮生長因子受體�。� 參考：《國際眼科雜志》2016年11期

【摘要】：新生血管是許多致盲性眼病的主要原因,例如糖尿病視網(wǎng)膜病變、早產(chǎn)兒視網(wǎng)膜病變、年齡相關(guān)性黃斑變性等。血管內(nèi)皮生長因子(vascular endothelial growth factor,VEGF)在新生血管的形成中起著重要的作用,被認(rèn)為是作用最強的血管生長因子。胎盤生長因子(placental growth factor,Pl GF)是VEGF家族中的一員,可促進新生血管生成,刺激內(nèi)皮細胞遷移增殖,介導(dǎo)免疫炎癥反應(yīng),且特異性表達于病理性新生血管,但在正常血管中不表達。因此近年來Pl GF逐漸受到人們關(guān)注。本文對Pl GF在新生血管性眼病中的作用機制進行探討。
[Abstract]:Neovascularization is the main cause of blindness, such as diabetic retinopathy, retinopathy of premature infants, age-related macular degeneration and so on. Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis and is considered to be the most effective vascular growth factor. Placental growth factor-PF is a member of VEGF family, which can promote angiogenesis, stimulate endothelial cell migration and proliferation, mediate immune inflammation, and express specifically in pathological neovascularization, but not in normal vessels. Therefore, in recent years, people pay more and more attention to Pl GF. In this paper, the mechanism of Pl GF in neovascular ophthalmopathy was discussed.
【作者單位】： 西安醫(yī)學(xué)院;三二0一醫(yī)院眼科;
【分類號】：R77
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本文編號：1907344