本文選題：血栓前狀態(tài) + 睡眠呼吸暫停低通氣指數(shù)�。� 參考：《新疆醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:分析阻塞性睡眠呼吸暫停低通氣綜合征(OSAHS)血栓前狀態(tài)的影響因素,為OSAHS患者靜脈血栓栓塞癥的預(yù)防提供依據(jù)和借鑒。方法:選取2013年6月至2016年7月在新疆醫(yī)科大學(xué)附屬第一醫(yī)院經(jīng)多導(dǎo)睡眠監(jiān)測(cè)(PSG)明確診斷為OSAHS并進(jìn)行了凝血、血栓與纖溶檢測(cè)及炎癥因子組合測(cè)定,同時(shí)排除存在其他可能影響凝血功能因素的患者共181名。其中符合血栓前狀態(tài)參考標(biāo)準(zhǔn)的患者56名,為血栓前狀態(tài)組,剩余125名患者凝血及血栓與纖溶檢測(cè)不滿足參考標(biāo)準(zhǔn),即非血栓前狀態(tài)組。分析、比較兩組患者年齡、性別、民族、體重指數(shù)(BMI)、睡眠呼吸暫停低通氣指數(shù)(AHI)、白介素-6(IL-6)、使用CPAP、合并慢性阻塞性肺疾病(COPD)和合并高血壓的的情況。結(jié)果:非條件Logistic回歸分析顯示OSAHS血栓前狀態(tài)的危險(xiǎn)因素有年齡(OR=1.215,95%CI:1.104-1.337)、IL-6(OR=1.124,95%CI:1.015-1.244)、AHI(OR=1.207,95%CI:1.103-1.320)、合并COPD(OR=8.034,95%CI:1.819-35.488)。CPAP(OR=0.231,95%CI:0.059-0.901)是OSAHS患者血栓前狀態(tài)的保護(hù)因素。結(jié)論:年齡、AHI、IL-6、合并COPD可能是OSAHS患者血栓前狀態(tài)的危險(xiǎn)因素,其中合并COPD可能是最重要的危險(xiǎn)因素。CPAP是OSAHS患者血栓前狀態(tài)的保護(hù)因素。
[Abstract]:Objective: to analyze the influencing factors of prethrombotic state of obstructive sleep apnea hypopnea syndrome (OSAHS) and to provide evidence and reference for the prevention of venous thromboembolism in patients with OSAHS. Methods: OSAHS was diagnosed by polysomnography in the first affiliated Hospital of Xinjiang Medical University from June 2013 to July 2016. Coagulation, thrombus and fibrinolysis were detected and inflammatory factors were determined. At the same time, 181 patients were excluded from other possible factors affecting coagulation function. Among them, 56 patients who met the reference standard of prethrombotic state were prethrombotic group, the remaining 125 patients did not meet the reference standard for coagulation, thrombus and fibrinolysis, that is, non-prethrombotic state group. Age, sex, nationality, body mass index (BMI), sleep apnea hypopnea index (AHI), interleukin-6 (IL-6), CPAP, chronic obstructive pulmonary disease (COPD) and hypertension were compared between the two groups. Results: Non-conditional Logistic regression analysis showed that the risk factors of prethrombotic state of OSAHS were as follows: CI1: 1.104-1.337T: CI1: 1.104-1.3371.12495: CI1: 1.015-1.244AHIOR1.207-95CIW 1.103-1.320, combined with COPDOR8.03495CIW 1.819-35.488. CPAPOR0.23195CICell 0.059-0.901 was the protective factor of prethrombotic state in OSAHS patients. Conclusion: COPD may be the risk factor of prethrombotic state in patients with OSAHS. COPD may be the most important risk factor. CPAP is the protective factor of prethrombotic state in OSAHS patients.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R766

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