本文選題：慢性鼻-鼻竇炎(Chronic + rhinosinusitis)�。� 參考：《南昌大學(xué)》2017年碩士論文

【摘要】：鼻炎(Rhinitis)被認(rèn)為是鼻腔黏膜的炎癥性疾病,高達(dá)40%的人群患有鼻炎。在所有引起鼻腔黏膜炎癥性疾病當(dāng)中,變應(yīng)性鼻炎(allergic rhinitis,AR)是最常見的一種,占1/6比重。AR的一系列臨床癥狀嚴(yán)重影響人們的日常生活,降低睡眠質(zhì)量和工作效率。目前AR被認(rèn)為是呼吸道系統(tǒng)疾病的表現(xiàn),且AR患者常伴發(fā)哮喘。過敏性哮喘患者的氣道上皮呈現(xiàn)不同程度的損傷,包括連接蛋白表達(dá)的減少,對損傷的敏感性增加,及組織重塑。慢性鼻-鼻竇炎(Chronic rhinosinusitis,CRS)是一種鼻腔鼻竇黏膜炎癥性疾病,臨床發(fā)病率高,影響15%的人群,且炎癥影響患者生活質(zhì)量和工作效率。其發(fā)病機制尚不明確。目前,多項研究證明慢性炎癥性疾病,例如哮喘、皮膚病、Crohn病等,與黏膜上皮細(xì)胞緊密連接蛋白表達(dá)的改變、上皮屏障功能破壞相關(guān)。目前一些研究認(rèn)為,慢性鼻-鼻竇炎患者鼻黏膜亦涉及上皮細(xì)胞屏障功能的破壞及緊密連接相關(guān)蛋白表達(dá)的改變。本文旨在對慢性鼻-鼻竇炎及變應(yīng)性鼻炎鼻腔黏膜上皮細(xì)胞屏障功能的破壞及緊密連接蛋白表達(dá)變化的研究進展進行綜述,試圖從鼻黏膜上皮屏障功能層面進一步研究慢性鼻-鼻竇炎及變應(yīng)性鼻炎的發(fā)病機制。
[Abstract]:Rhinitis is considered to be an inflammatory disease of nasal mucosa, with up to 40% of the population suffering from rhinitis. Among all the inflammatory diseases causing nasal mucosa, allergic rhinitis ARs is the most common one. A series of clinical symptoms, which account for 1 / 6 proportion, seriously affect people's daily life, reduce sleep quality and work efficiency. At present, AR is considered to be a manifestation of respiratory system diseases, and AR patients often develop asthma. Airway epithelium in patients with allergic asthma showed varying degrees of injury, including reduced expression of connexin, increased sensitivity to injury, and tissue remodeling. Chronic rhinosinusitis (CRS) is a kind of inflammatory disease of nasal cavity and sinusitis mucosa, which has a high clinical incidence and affects 15% of the population, and inflammation affects the quality of life and work efficiency of the patients. Its pathogenesis is not clear. At present, several studies have shown that chronic inflammatory diseases, such as asthma, skin disease and Crohn's disease, are related to the changes of tight junction protein expression in mucosal epithelial cells and the destruction of epithelial barrier function. Some studies suggest that the nasal mucosa of patients with chronic rhinosinusitis is also involved in the destruction of epithelial cell barrier function and the change of tight junction associated protein expression. The purpose of this article is to review the damage of nasal mucosal epithelial barrier function and the changes of tight junction protein expression in chronic rhinosinusitis and allergic rhinitis. This paper attempts to further study the pathogenesis of chronic rhinosinusitis and allergic rhinitis from the function of nasal epithelial barrier.
【學(xué)位授予單位】：南昌大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R765.21

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本文編號：1881175