本文選題：多焦視網(wǎng)膜電圖 + 雷珠單抗��； 參考：《南方醫(yī)科大學(xué)學(xué)報(bào)》2017年07期

【摘要】：目的應(yīng)用多焦視網(wǎng)膜電圖(mfERG)評(píng)價(jià)經(jīng)玻璃體腔注射雷珠單抗治療濕性老年性黃斑變性(AMD)前后視網(wǎng)膜功能的變化情況。方法前瞻性研究。共納入2014年10月~2016年1月在廣州愛爾眼科醫(yī)院診治的濕性老年性黃斑變性患者14例14只眼。所有患者接受玻璃體腔注射雷珠單抗治療。本研究采用1+PRN的治療方案。注射后每月復(fù)診,根據(jù)復(fù)診情況決定是否重復(fù)治療。治療前及首次治療后l、3、6個(gè)月,記錄最佳矯正視力、mfERG各環(huán)的潛伏期和振幅密度變化情況。結(jié)果末次隨訪時(shí),患者平均接受雷珠單抗注射2.86±1.58次。治療后1個(gè)月最佳矯正視力與術(shù)前相比無明顯差異(P=0.07),治療后3個(gè)月、6個(gè)月的視力與治療前視力相比較,逐漸提高,且差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。與治療前相比,治療后6個(gè)環(huán)的潛伏期均無明顯下降。治療后1個(gè)月、3個(gè)月、6個(gè)月,1環(huán)及2環(huán)的N1波、Pl波振幅密度的升高較治療前均有明顯的統(tǒng)計(jì)學(xué)差異(P0.05)。結(jié)論mfERG可以作為一種評(píng)價(jià)經(jīng)玻璃體腔注射雷珠單抗治療濕性AMD后患者視功能變化情況的良好指標(biāo)。
[Abstract]:Objective to evaluate the changes of retinal function before and after the treatment of wet age-related macular degeneration (AMDD) by intravitreal injection of Lei Zhu McAb with multifocal electroretinogram (mfERG). Methods prospective study. From October 2014 to January 2016, 14 eyes of 14 patients with wettable age-related macular degeneration were treated and treated in Guangzhou Eyre Ophthalmology Hospital. All patients were treated with intravitreal injection of Threzumab. A 1 PRN regimen was used in this study. Follow up every month after injection and decide whether to repeat treatment according to the condition of follow-up. The latency and amplitude density of every ring of best corrected visual acuity (BCVA) were recorded before and after the first treatment for 3 and 6 months. Results at the last follow-up, the patients received an average of 2.86 鹵1.58 injections of Lei Zhu McAb. There was no significant difference in the best corrected visual acuity (BCVA) between before and after treatment. The visual acuity of 3 months and 6 months after treatment was gradually improved compared with that before treatment, and the difference was statistically significant (P 0.05). Compared with before treatment, there was no significant decrease in the latency of the six rings after treatment. One month, three months, six months after treatment, the amplitude density of N1 wave P 1 wave and 2 ring N 1 wave P l wave increased significantly compared with that before treatment (P 0.05). Conclusion mfERG can be used as a good index to evaluate the changes of visual function in patients with wet AMD treated by intravitreal injection of Lei Zhu McAb.
【作者單位】： 愛爾眼科醫(yī)院集團(tuán)廣州愛爾眼科醫(yī)院;
【基金】：廣州市醫(yī)藥衛(wèi)生科技項(xiàng)目(20141A011100)
【分類號(hào)】：R774.5

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 Hui-Jun Qi;Xiao-Xin Li;Jun-Yan Zhang;Ming-Wei Zhao;;Efficacy and safety of ranibizumab for wet age-related macular degeneration in Chinese patients[J];International Journal of Ophthalmology;2017年01期

【共引文獻(xiàn)】

相關(guān)期刊論文 前3條

1 莒瑞紅;何曼莎;侯金佟;李夢(mèng)媛;張靜琳;武哲明;;多焦視網(wǎng)膜電圖對(duì)玻璃體腔注射雷珠單抗治療濕性老年性黃斑變性的療效評(píng)價(jià)[J];南方醫(yī)科大學(xué)學(xué)報(bào);2017年07期

2 湯萬波;王俊玲;王e，

本文編號(hào)：1871083