本文選題：阻塞性睡眠呼吸暫停低通氣綜合征(Obstructive + sleep�。� 參考：《山西醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:觀察阻塞性睡眠呼吸暫停低通氣綜合征(Obstructive sleep apnea-hypopnea syndrome,OSAHS)患者口服N-乙酰半胱氨酸泡騰片(N-acetylcysteine,NAC)治療前、后血清β2微球蛋白(β2-microglobulin,β2-MG)、胱抑素C(Cystatin C,CysC)及24小時(shí)尿蛋白水平的變化,探討NAC對(duì)OSAHS患者腎臟的保護(hù)作用。方法:收集2014年1月到2016年3月以不明原因蛋白尿而入住山西醫(yī)科大學(xué)第二醫(yī)院,經(jīng)空腹血清學(xué)檢查(β2-MG2.64mg/L、CysC1.03mg/L及24小時(shí)尿蛋白定量150mg)者,行整夜多導(dǎo)睡眠監(jiān)測(cè)后確診的中、重度(AHI≥15次/分)OSAHS的患者83例,隨機(jī)分為CPAP治療組43例(后有失訪者3例)、NAC治療組40例,觀察兩組患者入組前、治療后3個(gè)月、6個(gè)月的血清β2-MG、CysC水平及24小時(shí)尿蛋白變化情況。結(jié)果:1.治療前兩組患者血清β2-MG、CysC水平及24小時(shí)尿蛋白定量無(wú)明顯差異(P0.05);2.兩組間比較治療后血清β2-MG、CysC水平及24小時(shí)尿蛋白定量下降,有統(tǒng)計(jì)學(xué)差異(P0.05);3.血清β2-MG、CysC水平及24小時(shí)尿蛋白定量與治療時(shí)間負(fù)相關(guān)性(相關(guān)系數(shù)r值分別為-0.517、-0.594、-0.758,-0.605、-0.605、-0.815,P0.05)。結(jié)論:1.初步證實(shí)NAC通過(guò)改善氧化應(yīng)激反應(yīng),可達(dá)到治療或預(yù)防OSAHS并發(fā)的早期腎損傷;2.證實(shí)NAC的療效與用藥時(shí)間呈正相關(guān)。
[Abstract]:Objective: to observe the changes of serum 尾 2 microglobulin (尾 2 microglobulin, 尾 2 MGG, cystatin C(Cystatin CysC) and 24 hour urine protein levels in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) before and after treatment with N-acetylcysteine effervescent tablets. To investigate the protective effect of NAC on kidney of OSAHS patients. Methods: patients who were admitted to the second Hospital of Shanxi Medical University with unknown proteinuria from January 2014 to March 2016 were examined by fasting serology (尾 2-MG2.64mg / L CysC1.03mg / L and 24-hour urine protein ration 150mg / L). 83 patients with severe AHI 鈮，

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