發(fā)布時(shí)間：2018-05-03 12:35

  本文選題：鼻咽癌 + 動(dòng)態(tài)增強(qiáng)磁共振成像��； 參考：《暨南大學(xué)》2012年碩士論文

【摘要】：目的： 研究分析鼻咽癌（nasopharyngeal carcinoma，NPC）動(dòng)態(tài)增強(qiáng)MRI（dynamiccontrast-enhanced MRI，DCE-MRI）與擴(kuò)散加權(quán)成像（diffusion-weighted MRI，DWI）表現(xiàn)，加深對(duì)其認(rèn)識(shí)水平。 方法： 1、一般資料：收集我院2010年12月至2012年3月期間收治的經(jīng)病理證實(shí)NPC初診患者30例，均行常規(guī)MRI平掃+SE EPI DWI+DCE MRI+常規(guī)增強(qiáng)掃描。 2、圖像后處理：使用GE ADW4.2后處理工作站的Functool軟件對(duì)DCE MRI圖像和DWI圖像進(jìn)行數(shù)據(jù)后處理。繪制NPC病灶感興趣區(qū)，獲取DCE-MRI的T-SI曲線（Time-Signal Intensity curve，T-SI curve），分別測(cè)量并記錄感興趣區(qū)的ADC值和動(dòng)態(tài)增強(qiáng)特征性參數(shù)值，包括正性增強(qiáng)積分（positive enhancement integral，PEI）、至峰值時(shí)間（time to peak，TP）及最大上升斜率（maximum slope of increase，MSI）,手動(dòng)計(jì)算得出相對(duì)PEI值、相對(duì)TP值及相對(duì)MSI值，并進(jìn)行統(tǒng)計(jì)學(xué)分析。 3、統(tǒng)計(jì)方法：采用SPSS19.0統(tǒng)計(jì)軟件。統(tǒng)計(jì)量采用均數(shù)±標(biāo)準(zhǔn)差（x±s）的形式表示，對(duì)計(jì)數(shù)資料行χ2檢驗(yàn)，對(duì)計(jì)量資料行兩獨(dú)立樣本t檢驗(yàn)，P＜0.05為差異具有統(tǒng)計(jì)學(xué)意義。 結(jié)果： 1、NPC鼻咽病灶T-SI曲線表現(xiàn)為速升-平臺(tái)型（18例）、速升-緩降型（7例）和緩升-平臺(tái)型（5例）。 2、NPC鼻咽病灶與同側(cè)肌肉PEI值、TP值與MSI值的均數(shù)不同，，差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。 3、NPC I型、II型、III型的PEI值與相對(duì)PEI值的均數(shù)呈遞增趨勢(shì)，PEI值II型與III型之間、I型與III型之間差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）；相對(duì)PEI值II型與III型之間差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。 4、NPC I型、II型、III型的相對(duì)TP值均數(shù)呈遞減趨勢(shì)，但經(jīng)統(tǒng)計(jì)學(xué)處理，差異均無(wú)統(tǒng)計(jì)學(xué)意義（P＞0.05）；II型與III型之間的TP值差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。 5、NPC I型、II型、III型的MSI值與相對(duì)MSI值的均數(shù)呈遞增趨勢(shì)，但其差異均無(wú)統(tǒng)計(jì)學(xué)意義。 6、NPC I型、II型、III型的ADC值的均數(shù)呈遞減趨勢(shì)，但其差異均無(wú)統(tǒng)計(jì)學(xué)意義。 7、NPC鼻咽病灶T-SI曲線類型A型與C型在有無(wú)淋巴結(jié)轉(zhuǎn)移方面，差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。 結(jié)論： 不同影像表現(xiàn)類型的NPC在DCE-MRI及DWI掃描上有所不同，MR功能成像能初步反映腫瘤微循環(huán)及水分子運(yùn)動(dòng)狀態(tài)的生物學(xué)信息。
[Abstract]:Objective: To study and analyze the dynamic enhanced MRI(dynamiccontrast-enhanced DCE-MRI (nasopharyngeal carcinoma) and diffusion-weighted DWI (DWI) in nasopharyngeal carcinoma (NPC), and to deepen the understanding of the DCE-MRI. Methods: 1. General data: 30 patients with pathologically proved NPC were collected from December 2010 to March 2012, all of whom underwent conventional MRI plain EPI EPI DWI DCE MRI conventional enhanced scanning. 2, image post-processing: DCE MRI image and DWI image are processed by Functool software of GE ADW4.2 post-processing workstation. The region of interest in NPC was drawn, and the T-SI curve of DCE-MRI was obtained. The ADC values of the region of interest and the characteristic parameters of dynamic enhancement were measured and recorded. It includes positive enhancement integral slope, time to peak value and maximum slope of increasing slope. The relative PEI value, relative TP value and relative MSI value are calculated manually and analyzed statistically. 3. Statistical method: SPSS19.0 software was used. The statistics were expressed in the form of mean 鹵standard deviation (x 鹵s). The difference was statistically significant between the two independent samples (P < 0.05) and the counting data (蠂 2 test). Results: 1the T-SI curve of nasopharynx lesions showed rapid ascending to platform type in 18 cases, rapid ascending to slow descending type in 7 cases and slow ascending to platform type in 5 cases. 2the mean values of PEI and MSI in nasopharyngeal lesions and ipsilateral muscles were different (P < 0.05). 3There was an increasing trend between the PEI value and the relative PEI value of the PEI value and the relative PEI value. There was significant difference between III type II type and III type (P < 0.05), and there was significant difference between PEI type II type and III type (P < 0.05). (4) the relative TP value of NPCs type I type II and III type II showed a decreasing trend, but the difference was not statistically significant (P > 0.05) between the two types (P < 0.05), but there was no significant difference between the two types (P > 0.05), and there was no significant difference in TP between the two types (P < 0.05), but there was no significant difference between the two types (P > 0.05). (5) the mean of MSI and relative MSI showed an increasing trend, but there was no significant difference between them. The mean of ADC in type I and II of NPCs showed a decreasing trend, but there was no significant difference between them. There was significant difference in T-SI curve type A and C between NPC and NPC with or without lymph node metastasis (P < 0.05). Conclusion: NPC with different imaging types could reflect the biological information of tumor microcirculation and water molecule motion on DCE-MRI and DWI.
【學(xué)位授予單位】：暨南大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R445.2;R739.63

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 林蒙;羅德紅;;動(dòng)態(tài)增強(qiáng)MRI在顱底及頸部腫瘤中的應(yīng)用價(jià)值[J];當(dāng)代醫(yī)學(xué);2009年20期

2 張瑜,潘建基,陳旭霞,陳韻彬,陳梅,楊凌;CT與MRI對(duì)鼻咽癌T分期影響的比較[J];福建醫(yī)科大學(xué)學(xué)報(bào);2004年01期

3 呂建勛;徐堅(jiān)民;沈新平;陳耀強(qiáng);趙均雄;;鼻咽癌MRI動(dòng)態(tài)增強(qiáng)曲線及其時(shí)間窗[J];放射學(xué)實(shí)踐;2011年07期

4 凌人男;單軍;王曉枚;梁文華;成志強(qiáng);朱進(jìn);李靜芝;;DWI成像在宮頸癌分期中的應(yīng)用[J];廣東醫(yī)學(xué);2011年04期

5 劉妍;夏黎明;梁趙玉;王承緣;;DWI及動(dòng)態(tài)增強(qiáng)MRI在淋巴結(jié)病變鑒別診斷中的價(jià)值[J];湖南中醫(yī)藥大學(xué)學(xué)報(bào);2009年06期

6 李恒國(guó),莊承海,李啟權(quán);鼻咽癌細(xì)胞核DNA倍體和頸淋巴結(jié)轉(zhuǎn)移與預(yù)后的相關(guān)性[J];暨南大學(xué)學(xué)報(bào)(自然科學(xué)與醫(yī)學(xué)版);1999年02期

7 李輝;陳自謙;林宇寧;鐘群;肖慧;聶玫;;鼻咽癌調(diào)強(qiáng)適形放療前后動(dòng)態(tài)增強(qiáng)特征的研究[J];臨床軍醫(yī)雜志;2011年02期

8 丁忠祥,梁碧玲,沈君,黃穗喬,鐘鏡聯(lián),葉瑞心;動(dòng)態(tài)增強(qiáng)MRI在鼻咽癌斜坡改變中的初步應(yīng)用[J];臨床放射學(xué)雜志;2005年08期

9 金觀橋;蘇丹柯;劉麗東;朱旭娜;謝東;賴少侶;黃向陽(yáng);李強(qiáng);;CT灌注參數(shù)BF、PS臨界值對(duì)鼻咽癌放療后復(fù)發(fā)的診斷性研究[J];臨床放射學(xué)雜志;2011年02期

10 陳杰;邢偉;生晶;田建明;陳明;張永成;;相對(duì)ADC值鑒別良惡性淋巴結(jié)的實(shí)驗(yàn)研究[J];臨床放射學(xué)雜志;2011年02期

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