本文選題：葡萄糖轉(zhuǎn)運體 + 單羧酸轉(zhuǎn)運體��； 參考：《臨床耳鼻咽喉頭頸外科雜志》2017年07期

【摘要】：目的:本文旨在評估與代謝相關(guān)的葡萄糖轉(zhuǎn)運體1(GLUT-1)、單羧酸轉(zhuǎn)運體4(MCT-4)和碳酸酐酶9(CAⅨ)在喉鱗狀細胞癌中的表達及臨床意義。方法:收集經(jīng)手術(shù)切除的40例喉鱗狀細胞癌組織及10例癌旁組織,并對臨床資料進行整理分析。應(yīng)用免疫組織化學(xué)方法檢測GLUT-1、MCT-4與CAⅨ在40例喉鱗狀細胞癌和10例癌旁組織中的表達情況,評估它們與臨床病理學(xué)資料的關(guān)系。所有數(shù)據(jù)采用SPSS21.0統(tǒng)計學(xué)軟件進行分析。結(jié)果:在40例喉鱗狀細胞癌組織中GLUT-1、MCT-4和CAⅨ的陽性表達率分別為72.5%、75.0%和55.0%。其中,MCT-4在正常組織中表達較低或幾乎不表達,而GLUT-1在正常組織中具有干細胞活性的基底細胞層高表達。GLUT-1、MCT-4和CAⅨ的陽性表達與病理分級密切相關(guān)(均P0.05),其中低分化的喉鱗狀細胞癌中的陽性表達率遠高于高分化組。此外,在40例喉鱗狀細胞癌組織中MCT-4和CAⅨ的陽性表達和TNM分期相關(guān),差異有統(tǒng)計學(xué)意義(均P0.05)。MCT-4和CAⅨ在Ⅲ~Ⅳ期的表達率遠高于Ⅰ~Ⅱ期。GLUT-1、MCT-4和CAⅨ的表達與患者的年齡、吸煙量及有無淋巴結(jié)轉(zhuǎn)移及腫瘤的位置無關(guān)(P0.05),GLUT-1、MCT-4和CAⅨ呈正相關(guān)。結(jié)論:葡萄糖攝取與酸性微環(huán)境在喉鱗狀細胞癌代謝重塑和腫瘤的侵襲及演進密切相關(guān),因此,在缺氧的微環(huán)境下靶向與代謝相關(guān)的蛋白質(zhì)或許是治療侵襲性腫瘤的有效策略。
[Abstract]:Objective: to evaluate the expression and clinical significance of glucose transporter (GLUT-1), monocarboxylic acid transporter (MCT-4) and carbonic anhydrase (9(CA IX) in laryngeal squamous cell carcinoma (LSCC). Methods: 40 cases of laryngeal squamous cell carcinoma and 10 cases of adjacent tissues were collected and analyzed. The expression of GLUT-1 MCT-4 and CA IX in 40 cases of laryngeal squamous cell carcinoma (LSCC) and 10 cases of paracancerous tissues were detected by immunohistochemical method, and the relationship between them and clinicopathological data was evaluated. All the data were analyzed by SPSS21.0 statistical software. Results: in 40 cases of laryngeal squamous cell carcinoma, the positive rates of GLUT-1, MCT-4 and CA IX were 72.5% and 55.0%, respectively. The expression of MCT-4 in normal tissues was low or almost non-expressed. However, the positive expression of GLUT-1 in the basal cell layer with stem cell activity. GLUT-1, MCT-4 and CA IX were closely related to the pathological grade (P0.05), and the positive expression rate in poorly differentiated laryngeal squamous cell carcinoma was much higher than that in well-differentiated laryngeal squamous cell carcinoma. In addition, the positive expression of MCT-4 and CA IX in 40 cases of laryngeal squamous cell carcinoma was correlated with the stage of TNM, and the difference was statistically significant (the expression rates of P0.05).MCT-4 and CA IX in stage 鈪，

本文編號：1824582