發(fā)布時(shí)間：2018-04-26 04:16

  本文選題：聽覺事件誘發(fā)電位 + 漢語��； 參考：《南方醫(yī)科大學(xué)》2012年碩士論文

【摘要】：目的 1、采用不同刺激聲(包括純音、實(shí)意字、雙音節(jié)詞和數(shù)字)誘發(fā)聽覺事件相關(guān)電位(auditory event-related potentials, AERP),探討漢語言語聲刺激的不同形式測試中國人AERP的可行性； 2、比較純音和三種不同漢語言語刺激聲在最適強(qiáng)度時(shí)誘發(fā)AERP波形,分析各波形中P3潛伏期及幅值差異,并對AERP波形進(jìn)行量化評分,探討刺激聲與AERP波形的關(guān)系； 3、比較不同言語刺激聲誘發(fā)AERP波形在單耳的差別,分析言語優(yōu)勢半球的特點(diǎn),進(jìn)一步探討左右半球與不同言語處理過程的關(guān)系。 方法 根據(jù)我國漢語語言特點(diǎn)、言語測聽及AERP測試聲刺激的要求篩選出漢語單音節(jié)字、雙音節(jié)詞、數(shù)字表,將各表通過立體錄音、剪輯、轉(zhuǎn)換,編輯成與AERP測試軟件相兼容的言語測試信號,隨機(jī)選定靶刺激與非靶刺激,測試強(qiáng)度(感覺級)設(shè)置為60dB SL。分別采用不同的漢語言語(包括實(shí)意字、雙音節(jié)詞和數(shù)字)及純音作為聲刺激對正常青年人37名(70耳)進(jìn)行AERP測試,對各組AERP波形進(jìn)行標(biāo)記并量化評分。比較言語和純音刺激聲誘發(fā)的AERP的潛伏期、幅值及波形評分在各組之間有無統(tǒng)計(jì)學(xué)差異；分析不同聲刺激對P300的影響是否也存在于左右耳之間,比較純音和三種不同漢語言語刺激聲在最適強(qiáng)度時(shí)誘發(fā)的AERP波形在左右耳的差別,進(jìn)一步探討左右半球與不同言語處理過程的關(guān)系。 結(jié)果 不同漢語言語和純音均可以記錄到典型的AERP波形,且各組之間的P3引出率比較存在顯著性差異(X2=9.046,P=0.029)。其中以雙音節(jié)詞刺激聲最容易記錄到,引出率為98.6%,與純音組間比較差異具有統(tǒng)計(jì)學(xué)意義(X2=7.992,P=0.0050.05/6,6為比較次數(shù)),而其它組間比較AERP引出率無顯著差異(P值均0.05)。各組P3波形量化評分及N2-P3振幅在不同刺激聲之間的差異無明顯統(tǒng)計(jì)學(xué)意義(前者F=1.795,P=0.496；后者F=0.800,P=0.496),但從整體來看,字和雙音節(jié)詞誘發(fā)的AERP波形較數(shù)字和純音平滑,雜波少。不同刺激聲組間P3的平均潛伏期有顯著性差異(F=5.088,P=0.005),以數(shù)字組誘發(fā)的P3潛伏期最長,與其他三組比較差異均具有統(tǒng)計(jì)學(xué)意義(P值均0.05),而其它組間的P3潛伏期相比較則無明顯差異(P值均0.05)。對四種不同刺激聲測試時(shí)雙耳均能記錄到典型的AERP波形中N2潛伏期、P3潛伏期、N2-P3幅值分別進(jìn)行單耳比較,發(fā)現(xiàn)左耳N2、P3平均潛伏期在不同組間均存在顯著性差異(前者F=3.489,P=0.020；后者F=8.343,P=0.000)。右耳N2、P3平均潛伏期在四個(gè)組間差異無明顯統(tǒng)計(jì)學(xué)意義(前者F=0.603,P=0.550；后者F=0.323,P=0.808),不同組間N2-P3幅值在單耳的比較亦無顯著差異(左耳F=1.690,P=0.177；右耳F=1.644,P=0.187)。 結(jié)論 1、除純音和字外,漢語言語的其它形式,如雙音節(jié)詞、數(shù)字也適用于AERP測試刺激聲的要求,可以得到滿意的AERP波形,同樣適合用于中國人的AERP測試,為言語測試AERP在臨床上的進(jìn)一步推廣提供了一種適合中國人的更有實(shí)際意義的測試方法； 2、在最佳測試強(qiáng)度時(shí),言語刺激聲比純音更容易記錄到典型的AERP波形,其中以刺激聲為雙音節(jié)詞較純音更容易記錄到； 3、從所有數(shù)據(jù)和波形可以看出,刺激聲為字和雙音節(jié)詞時(shí)誘發(fā)的AERP波形較數(shù)字和純音平滑,雜波少,波形更典型； 4、刺激聲內(nèi)容對P300潛伏期的影響有統(tǒng)計(jì)學(xué)意義,數(shù)字誘發(fā)的P3潛伏期較其它組明顯延長,而對P300幅值的影響無統(tǒng)計(jì)學(xué)意義； 5、左耳記錄到的AERP的N2潛伏期、P3潛伏期在三種不同言語、純音刺激時(shí)的差異均具有統(tǒng)計(jì)學(xué)意義,其中以數(shù)字誘發(fā)的P3潛伏期最長,而右耳記錄到的AERP各參數(shù)在不同刺激聲誘發(fā)時(shí)均無明顯差異； 6、無論是言語刺激聲還是純音刺激聲,左側(cè)大腦半球在言語處理過程中均處于優(yōu)勢地位,但是并不是絕對和唯一的優(yōu)勢半球。左右半球在言語處理過程中是相互協(xié)調(diào)、相互補(bǔ)償?shù)摹?br/>[Abstract]:objective
1, the auditory event related potential (auditory event-related potentials, AERP) was induced by different stimuli (including pure tone, real word, double syllable word and number) to explore the feasibility of different forms of Chinese language sound stimulation to test the Chinese AERP.
2, comparing pure tone and three different Chinese speech stimuli to induce AERP waveform at the optimum intensity, analyze the difference of P3 latency and amplitude in each waveform, and quantify the AERP waveform, and discuss the relationship between the stimulus sound and the AERP waveform.
3, compare the difference of AERP waveform in single ear induced by different speech stimuli, analyze the characteristics of speech dominant hemisphere and further explore the relationship between the left and right hemispheres and the different speech processing.
Method
According to the characteristics of Chinese language, speech audiometry and AERP test sound stimulation, Chinese monosyllabic words, double syllable words and digital tables are selected for speech test signals that are compatible with AERP testing software by stereo recording, editing, conversion and editing, and the target stimuli and non target stimuli are randomly selected, and the test intensity (sensory level) is set to 60dB SL. used different Chinese language (including real words, double syllable words and numbers) and pure tone as sound stimulation to test 37 normal young people (70 ears). The AERP waveform of each group was marked and quantified. The latent period, amplitude and waveform score of the AERP were compared between the speech and the pure tone stimuli. The differences in the effects of different acoustic stimuli on P300 are also found between the left and right ears, and the difference in the left and right ears of the AERP waves induced by the pure tone and the three different Chinese speech stimuli at the optimum intensity is further discussed and the relationship between the left and right hemisphere and the different speech processing processes is further explored.
Result
Different Chinese language and pure tone can record a typical AERP waveform, and there is a significant difference in the P3 extraction rate between each group (X2=9.046, P=0.029). Among them, the double syllable word stimulus is the most easy to record, the extraction rate is 98.6%, and the difference between the pure tone group and the pure tone group has the statistical significance (X2=7.992, P=0.0050.05/6,6 is the comparison number). There was no significant difference in AERP extraction rate between other groups (P value was 0.05). There was no significant difference in the difference of P3 waveform and N2-P3 amplitude between different stimuli (the former F=1.795, P=0.496; the latter F=0.800, P=0.496), but from the overall point of view, the AERP waveforms induced by words and double syllables were more smooth and less clutter than those of digital and pure tones. The average latency of P3 between different stimuli groups was significantly different (F=5.088, P=0.005). The latency of P3 induced by digital group was the longest, and the difference between the other three groups was statistically significant (P value was 0.05), while the P3 latency of other groups was not significantly different (P value was 0.05). Both ears were recorded for four different stimuli. The N2 latency, P3 latency and N2-P3 amplitude in the typical AERP waveforms were compared with single ear, and the average latency of N2 and P3 in the left ear was found to be significantly different between different groups (the former F=3.489, P=0.020; the latter F=8.343, P=0.000). The right ear N2, the P3 average latency was not statistically significant between the four groups. 0, the latter F=0.323, P=0.808), there was no significant difference in amplitude of N2-P3 between different groups (left ear F=1.690, P=0.177; right ear F=1.644, P=0.187).
conclusion
1, in addition to pure tone and word, other forms of Chinese speech, such as double syllable words, are also applicable to the requirements of AERP test stimulus sound, and can get a satisfactory AERP waveform. It is also suitable for the AERP test of Chinese people. It provides a more practical test for the further popularization of the speech test AERP for the Chinese people. Law;
2, at the best test intensity, the speech stimulus is more easily recorded than the pure tone in the typical AERP waveform, in which the double syllable words with the stimulus sound are more easily recorded than the pure tone.
3, from all the data and waveforms, we can see that the AERP waveform induced by the stimulus and double syllable words is more smooth than the number and pure tone, and the clutter is less and the waveform is more typical.
4, the effect of stimulus content on the latency of P300 was statistically significant, and the latency of digital P3 was significantly longer than that of the other groups, but there was no significant effect on the P300 amplitude.
5, the N2 latency of AERP recorded by the left ear, the P3 latency in three different languages, the differences of pure tone stimulation were statistically significant, and the latency of P3 induced by digital was the longest, and the AERP parameters recorded in the right ear were not significantly different when the stimuli were induced by different stimuli.
6, both verbal and pure tone stimulation, the left hemisphere is dominant in the process of speech processing, but it is not the absolute and unique dominant hemisphere. The left and right hemispheres coordinate and compensate each other in the process of speech processing.

【學(xué)位授予單位】：南方醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R764

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