發(fā)布時間：2018-04-22 12:54

  本文選題：抗VEGF + 新生血管性青光眼��； 參考：《廣西醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:評估抗VEGF藥物玻璃體腔注射輔助青光眼Ahmed減壓閥植入術(shù)對新生血管性青光眼治療效果的影響方法:檢索國內(nèi)外數(shù)據(jù)庫,囊括以下數(shù)據(jù)庫:Pubmed、The Cochrane Library、EMBASE、維普中文科技期刊數(shù)據(jù)庫、中國知網(wǎng)、萬方數(shù)據(jù)庫,選取2017年1月1日前的文獻,主題是關(guān)于新生血管性青光眼Ahmed減壓閥植入術(shù)前或術(shù)中是否給予抗VEGF藥物玻璃體腔注射的對照研究。納入7篇文章,通過提取數(shù)據(jù),應(yīng)用Comprehensive Meta Analysis2.0軟件,眼壓下降幅度(基礎(chǔ)眼壓與觀察終點的眼壓之差)IOPR作為主要的評估指標(biāo),手術(shù)成功率的比值比(OR)及95%可信區(qū)間(confidence interval,CI)作為次要評估指標(biāo),并分析術(shù)后并發(fā)癥。結(jié)果:本系統(tǒng)評價納入七項研究,299例患者308只眼。Meta分析結(jié)果顯示,抗VEGF藥物玻璃體腔注射輔助青光眼Ahmed減壓閥植入術(shù)與單純Ahmed青光眼減壓閥植入手術(shù)相比,降眼壓作用稍強,術(shù)后1年眼壓平均低4.182±1.765mm Hg(P0.05)。抗VEGF玻璃體腔注射輔助Ahmed青光眼減壓閥植入術(shù)與Ahmed青光眼減壓閥植入術(shù)相比,兩組術(shù)后1年手術(shù)成功率的差異沒有統(tǒng)計學(xué)意義。前者可以減少術(shù)后前房積血的發(fā)生。結(jié)論:抗VEGF藥物玻璃體腔注射輔助Ahmed青光眼減壓閥植入術(shù)與單純Ahmed青光眼減壓閥植入術(shù)相比,在降低眼壓方面更為有效。兩者在手術(shù)成功率方面的差異無統(tǒng)計學(xué)意義�？筕EGF藥物的使用能減少術(shù)后前房積血的發(fā)生。
[Abstract]:Objective: to evaluate the effect of Ahmed pressure relief valve implantation on neovascular glaucoma with anti- VEGF drug intravitreal injection. Methods: to search the domestic and foreign databases, including the following databases: the Cochrane Library EMBASE, the Chinese Journal of Science and Technology database. China Zhiwang, Wanfang database, selected literature before January 1, 2017, the subject is whether to give intravitreal injection of anti- drugs before or during Ahmed pressure relief valve implantation in neovascular glaucoma. Seven articles were included, and the Comprehensive Meta Analysis2.0 software was used to extract the data. The decrease of IOP (the difference between the basic IOP and the IOP at the observation end point) was used as the main evaluation index. The ratio of success rate and 95% confidence interval (CI) were used as secondary evaluation indexes and postoperative complications were analyzed. Results: in this systematic evaluation, 308 eyes of 299 patients were included in this study. The results of Meta analysis showed that the intraocular pressure relief effect was slightly stronger than that of simple Ahmed glaucoma relief valve implantation, compared with that of Ahmed pressure relief valve implantation assisted by anti- VEGF drug intravitreal injection. The mean IOP was 4.182 鹵1.765mm HgG P 0.05 after 1 year postoperatively. There was no significant difference in the postoperative success rate between the two groups in terms of anti- intravitreal injection assisted Ahmed glaucoma pressure relief valve implantation and Ahmed glaucoma pressure relief valve implantation. The former can reduce the incidence of postoperative hyphema. Conclusion: the anti- VEGF drug intravitreal injection assisted Ahmed glaucoma pressure relief valve implantation is more effective in reducing intraocular pressure than that of Ahmed glaucoma pressure relief valve implantation alone. There was no significant difference in surgical success rate between the two groups. The use of anti-VEGF drugs can reduce the incidence of postoperative hyphema.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R779.6

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