本文選題：極重度突發(fā)性聾 + 巴曲酶��； 參考：《中國(guó)醫(yī)院藥學(xué)雜志》2017年19期

【摘要】：目的:觀察巴曲酶注射液聯(lián)合前列地爾注射液治療極重度突發(fā)性聾的有效性和安全性。方法:將56例符合納入標(biāo)準(zhǔn)的患者隨機(jī)分為2組,在基礎(chǔ)治療相同情況下,治療組使用巴曲酶注射液聯(lián)合前列地爾、對(duì)照組單獨(dú)使用前列地爾,療程10 d,觀察2組患者聽(tīng)力及伴隨癥狀的改善情況。結(jié)果:治療組對(duì)極重度突發(fā)性聾聽(tīng)力改善的總有效率為70.0%,對(duì)照組為46.1%,2組間比較,差異有極顯著性統(tǒng)計(jì)學(xué)意義(P0.01),對(duì)伴隨癥狀改善治療組優(yōu)于對(duì)照組。同時(shí)臨床觀察期間的2組均未發(fā)現(xiàn)明顯的不良反應(yīng)。結(jié)論:巴曲酶注射液聯(lián)合前列地爾治療極重度突發(fā)性聾是具有良好的療效且安全性好,值得臨床推廣。
[Abstract]:Objective: to observe the efficacy and safety of batroxobin injection combined with alprostadil injection in the treatment of extremely severe sudden deafness.Methods: 56 patients who met the inclusion criteria were randomly divided into two groups. Under the same condition of basic treatment, the treatment group was treated with batroxobin injection combined with alprostadil, while the control group was treated with alprostadil alone.After 10 days of treatment, the improvement of hearing and associated symptoms was observed in both groups.Results: the total effective rate of hearing improvement in the treatment group was 70.0 and that in the control group was 46.1. The difference was statistically significant (P 0.01). The treatment group was superior to the control group in improving the associated symptoms.At the same time, no significant adverse reactions were found in the two groups during the clinical observation.Conclusion: Batroxobin injection combined with alprostadil has good efficacy and safety in the treatment of extremely severe sudden deafness.
【作者單位】： 成都市第五人民醫(yī)院耳鼻咽喉頭頸外科;
【分類號(hào)】：R764.437

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