本文選題：咽喉部血管瘤　切入點：電子喉鏡　出處：《福建醫(yī)科大學》2012年碩士論文　論文類型：學位論文

【摘要】：目的：探討在電子喉鏡直視下，根據(jù)MRI掃描結(jié)果按ROI測量得到瘤體體積，“精確”定位、定量瘤內(nèi)注射平陽霉素混合液治療咽喉部血管瘤的方法及療效，為研究和臨床治療提供參考。 方法：收集2007年1月～2011年11月期間就診福建醫(yī)科大學附屬第一醫(yī)院耳鼻喉科門診被診斷為咽喉部血管瘤，行MRI平掃+增強掃描診斷為海綿狀血管瘤患者25例，經(jīng)MRI測量瘤體體積，電子喉鏡準確定位后，，利用內(nèi)窺鏡專用注射小針頭（奧林帕斯WF-1816PN），根據(jù)瘤體體積，按比例瘤內(nèi)精確定量注射平陽霉素混合液。25例患者在療程結(jié)束后6個月，根據(jù)電子喉鏡及MRI檢查結(jié)果，按標準判斷療效，隨訪觀察患者復發(fā)情況。 結(jié)果：25例患者在經(jīng)瘤內(nèi)精確定量注射平陽霉素混合液治療療程結(jié)束后6個月按標準判斷療效,結(jié)果顯示25例患者中20例治愈，治愈率80%；3例顯效，顯效率12%；有效1例，有效率4%；無效1例，無效率4%。1例（4%）患者在首次注射后1周內(nèi)出現(xiàn)局部潰瘍，三周后自行好轉(zhuǎn)，1例患者（4%）出現(xiàn)咽部膿腫，后經(jīng)收住院行“咽部膿腫切開引流術”治愈。經(jīng)半年以上的隨訪，均未見復發(fā)。 結(jié)論：根據(jù)瘤體MRI體積測量，定量控制平陽霉素瘤內(nèi)介入治療，該方法操作簡單，安全可靠，治愈率高，創(chuàng)傷小，副作用少。
[Abstract]:Objective: to explore the method and effect of quantitative injection of pingyangmycin in the treatment of pharyngeal and laryngeal hemangioma under direct view of electronic laryngoscope and ROI measurement according to the results of MRI scan, "accurate" localization and quantitative injection of pingyangmycin in the treatment of pharynx and larynx hemangioma. To provide reference for research and clinical treatment. Methods: from January 2007 to November 2011, 25 cases of hemangioma of pharynx and larynx were diagnosed by otolaryngology, first affiliated Hospital of Fujian Medical University, and diagnosed as cavernous hemangioma by plain enhanced MRI scan. The volume of the tumor was measured by MRI. After the accurate localization of the tumor by electronic laryngoscope, the small needle was injected with the special endoscope (Orlingpas WF-1816PNN). According to the volume of the tumor, the pingyangmycin mixture was accurately and quantitatively injected into the tumor according to the volume of the tumor. 25 patients were injected with pingyangmycin mixture 6 months after the end of the course of treatment. According to the results of electronic laryngoscope and MRI, the curative effect was judged according to the standard, and the recurrence of the patients was observed. Results the curative effect of 25 cases was judged according to the standard six months after the end of the course of treatment by accurate and quantitative injection of pingyangmycin through tumor. The results showed that 20 of 25 cases were cured, the cure rate was 80% and 3 cases had remarkable effect, the effective rate was 12%, and 1 case was effective. The effective rate was 4%; the effective rate was 1 case; the ineffective rate was 4.1 cases; and the patient developed local ulcer within 1 week after the first injection, and 1 case of spontaneous improvement after 3 weeks showed a pharyngeal abscess. The patient was cured by pharyngeal abscess incision and drainage. No recurrence was found after more than half a year follow-up. Conclusion: according to MRI volume measurement, quantitative control of pingyangmycin intratumoral interventional therapy is simple, safe and reliable, high cure rate, less trauma and less side effects.
【學位授予單位】：福建醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R739.6

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