本文選題：喉癌　切入點：多藥耐藥　出處：《中華全科醫(yī)學》2016年06期 　論文類型：期刊論文

【摘要】：目的探討P-糖蛋白(P-gp)、多藥耐藥相關(guān)蛋白(MRP1)、肺耐藥相關(guān)蛋白(LRP)和谷胱甘肽-S轉(zhuǎn)移酶(GST-π)在中晚期喉鱗狀細胞癌患者放療前后腫瘤組織中表達及放療對喉癌耐藥基因的影響。方法收集76例中晚期喉癌患者,其中低分化鱗狀細胞癌8例,中高分化鱗狀細胞癌68例,采用免疫組織化學法檢測在不同類型喉癌組織和放療前后癌組織中P-gp、MRP1、LRP和GST-π的表達強度和分布,分析其表達情況。結(jié)果喉鱗狀細胞癌具有原發(fā)耐藥性,P-gp在低分化鱗癌和中高分化鱗癌2種病理類型喉癌組織中呈高強度強陽性表達,與MRP1、LRP和GST-π三種耐藥蛋白比較差異有統(tǒng)計學意義(F=8.0839,P=0.0438);MRP1在低分化鱗癌中的表達明顯高于中高分化鱗癌中的陽性表達率,其差異有統(tǒng)計學意義(t=9.575,P0.001);放射治療后P-gp、MRP1、LRP和GST-π陽性表達率與放射治療前相比均有增高,其中P-gp在放療前后表達陽性率分別為(53.26±7.94)%、(79.37±7.73)%,表達差異有統(tǒng)計學意義(t=6.28,P0.05);MRP1在放療前后表達陽性率分別為(31.14±8.96)%、(54.76±9.53)%,差異有統(tǒng)計學意義(t=7.35,P0.05)。結(jié)論 P-gp、MRP1、LRP和GST-π在喉鱗狀細胞癌中表達存在差異性;放射治療可以增加喉鱗狀細胞癌耐藥基因蛋白過表達,特別是放療后P-gp和MRP1的過表達影響喉癌化療方案的制定。
[Abstract]:Objective to investigate the P- glycoprotein (P-gp), multidrug resistance associated protein (MRP1), lung resistance related protein (LRP) and glutathione -S transferase (GST- PI) expression in patients before and after radiotherapy in advanced laryngeal squamous cell carcinoma tumor and radiotherapy on laryngeal carcinoma multidrug resistance gene. Methods: 76 cases of patients with advanced laryngeal carcinoma in which, 8 cases of poorly differentiated squamous cell carcinoma, 68 cases of high differentiated squamous cell carcinoma, detected by immunohistochemistry before and after different types of laryngeal carcinoma tissues and radiotherapy carcinoma P-gp, MRP1 expression intensity and distribution of LRP and GST- of PI, the analysis of the results. The expression of laryngeal squamous cell carcinoma with the original drug resistance, P-gp in poorly differentiated squamous cell carcinoma and in highly differentiated squamous cell carcinoma in 2 different pathologic types of laryngeal carcinoma with high intensity and strong expression of MRP1, there was statistical significance of three multidrug resistance protein LRP and GST- phase difference (F=8.0839, P=0.0438); MRP1 in low differentiation scale The expression of cancer was significantly higher than the positive expression in well differentiated squamous cell carcinoma, the difference was statistically significant (t=9.575, P0.001); after radiotherapy P-gp, MRP1, LRP and GST- PI and the positive expression rate of radiation than before treatment were increased, the expression rates of P-gp before and after radiotherapy (53.26 + 7.94)%, (79.37 + 7.73)%, the expression difference was statistically significant (t=6.28, P0.05) MRP1 before and after radiotherapy; the positive expression rate of (31.14 + 8.96)% and (54.76 + 9.53)%, the difference was statistically significant (t=7.35, P0.05). Conclusion: P-gp, MRP1, LRP and GST- on the expression of PI there are differences in laryngeal squamous cell carcinoma; radiotherapy can increase the laryngeal squamous cell carcinoma multidrug resistance gene expression, especially the influence of formulation of laryngeal carcinoma chemotherapy over expression of P-gp and MRP1 after radiotherapy.

【作者單位】： 杭州師范大學附屬醫(yī)院耳鼻咽喉頭頸外科;杭州師范大學附屬醫(yī)院病理科;
【基金】：浙江省自然科學基金(Y2100578) 杭州市科技發(fā)展基金(20110833B09)
【分類號】：R739.65

【相似文獻】

相關(guān)期刊論文 前9條

1 孫春明;王之敏;周岱;許期年;左劍玲;王秀云;周幽心;康蘇婭;;耐藥基因蛋白在人腦膠質(zhì)瘤組織中的表達[J];中國神經(jīng)腫瘤雜志;2005年01期

2 王兆平;高志斌;柳君;;免疫細胞化學在癌性胸水沉積物耐藥基因蛋白檢測中的應用[J];現(xiàn)代實用醫(yī)學;2009年05期

3 李杰,許良中,吳炅;三種耐藥基因蛋白表達在乳腺癌中的臨床意義[J];癌癥;2001年08期

4 劉鵬熙;李幸運;周瑞芳;王一安;;多種耐藥基因蛋白在初治乳腺癌中的表達[J];臨床腫瘤學雜志;2007年09期

5 龔建平;姚宇鋒;唐金海;秦建偉;;術(shù)前化療對乳腺癌組織激素受體及耐藥基因蛋白表達的影響[J];中國腫瘤臨床;2012年23期

6 張彩蘭;劉斌;楊艷麗;蘇勤軍;張登才;史敏;錢震;董亮;哈英娣;;多藥耐藥基因PgP、ToPo-Ⅱ、GST-π與Ki-67在肺癌中的表達及其臨床病理學意義[J];現(xiàn)代腫瘤醫(yī)學;2013年01期

7 劉會寧,王拯民,王建軍,高立平,張朱欣,白玉山;食管鱗狀細胞癌組織中多藥耐藥基因蛋白表達的臨床意義[J];河北醫(yī)藥;2000年11期

8 鮑揚漪,胡向陽,孟剛;多種耐藥基因蛋白在乳腺癌中的表達及其臨床意義[J];安徽醫(yī)藥;2005年06期

9 ;[J];;年期

相關(guān)會議論文 前1條

1 李杰;許良中;吳炅;;多種耐藥基因蛋白表達在乳腺癌中的臨床意義[A];2000全國腫瘤學術(shù)大會論文集[C];2000年

相關(guān)碩士學位論文 前1條

1 張燕;五種耐藥基因蛋白在常見惡性腫瘤中的表達特點及臨床意義[D];重慶醫(yī)科大學;2007年

，

本文編號：1587542