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  本文關(guān)鍵詞： 變應(yīng)性鼻炎 免疫治療 酪酸梭菌 雙歧桿菌 CD4+CD25+調(diào)節(jié)T細胞　出處：《山西醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:通過檢測參與本實驗的變應(yīng)性鼻炎患者外周血中CD4+CD25+Treg細胞在外周血CD4+Treg細胞中的所占比(%),進一步比較和探討口服益生菌和特異性免疫治療在治療變應(yīng)性鼻炎中存在的聯(lián)合作用。方法:1.根據(jù)變應(yīng)性鼻炎的診斷標準、排除標準收集符合要求的變應(yīng)性鼻炎患者42例(簽署知情同意書),隨機分成3組:(1)常樂康組(14例):僅服用常樂康治療,一個療程,連續(xù)服用3個月。(2)免疫治療(SIT)組(14例):僅進行特異性免疫治療,治療3個月。(3)常樂康+免疫治療(SIT)組(14例):同時口服常樂康和進行特異性免疫治療。實驗標本為治療前后變應(yīng)性鼻炎患者的外周血標本。采用流式細胞儀測定外周血中的CD4+CD25+Treg細胞的含量,統(tǒng)計、比較、分析和探討口服益生菌和特異性免疫治療在治療變應(yīng)性鼻炎中存在的聯(lián)合作用。結(jié)果:1.三組治療后的CD4+CD25+Treg細胞含量均高于治療前,差異有統(tǒng)計學(xué)意義(P0.05)。2.常樂康+免疫治療(SIT)組的CD4+CD25+Treg細胞含量明顯高于常樂康組,差異有統(tǒng)計學(xué)意義(P0.05)。常樂康+免疫治療(SIT)組的CD4+CD25+Treg細胞含量明顯高于免疫治療組,差異有統(tǒng)計學(xué)意義(SIT)組(P0.05)。結(jié)論:1.三組治療后的外周血中CD4+CD25+Treg細胞含量均高于治療前,表明這三種治療方案對變應(yīng)性鼻炎的治療均是有效的。2.與常樂康組,免疫治療(SIT)組相比,常樂康+免疫治療(SIT)組中CD4+CD25+Treg細胞含量增多,表明口服益生菌和特異性免疫治療在治療變應(yīng)性鼻炎中具有聯(lián)合作用,聯(lián)合作用優(yōu)于單個作用。
[Abstract]:Objective: to compare and explore the effect of oral probiotics and specific immunotherapy on allergic rhinitis patients by detecting the percentage of CD4 CD25 Treg cells in peripheral blood CD4 Treg cells. Methods 1. According to the diagnostic criteria of allergic rhinitis, The exclusion criteria collected 42 patients with allergic rhinitis who met the requirements (sign informed consent form and were randomly divided into 3 groups: 1) Changle Kang group (14 cases): only take Changle Kang treatment, a course of treatment, After 3 months of continuous administration, 14 patients in the SIT-treated group were treated with specific immunotherapy only. After 3 months of treatment, 14 patients in the Changlekang immunotherapy group were treated with both oral and specific immunotherapy. The experimental specimens were peripheral blood samples from patients with allergic rhinitis before and after treatment. Flow cytometry was used to determine the results. The content of CD4 CD25 Treg cells in peripheral blood, The combined effects of oral probiotics and specific immunotherapy in the treatment of allergic rhinitis were analyzed and discussed. Results the CD4 CD25 Treg cells in the three groups after treatment were higher than those before treatment. The content of CD4 CD25 Treg cells in the Changlekang immunotherapy group was significantly higher than that in the Changle Kang group, and the difference was statistically significant (P 0.05). The CD4 CD25 Treg cell content in the Changlekang immunotherapy group was significantly higher than that in the immunotherapy group. Conclusion the content of CD4 CD25 Treg cells in peripheral blood of the three groups after treatment is higher than that before treatment, indicating that these three treatments are effective in the treatment of allergic rhinitis. The content of CD4 CD25 Treg cells in Changlekang immunotherapy group was increased, which indicated that oral probiotics and specific immunotherapy had a combined effect in the treatment of allergic rhinitis, and the combined effect was better than that of single action.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R765.21

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