發(fā)布時(shí)間：2018-01-29 02:13

  本文關(guān)鍵詞： 睡眠呼吸暫停低通氣綜合征 阻塞性 髓過(guò)氧化物酶 胰淀素 胰島素抵抗　出處：《臨床耳鼻咽喉頭頸外科雜志》2017年11期 　論文類(lèi)型：期刊論文

【摘要】：目的:探討成人OSAHS患者短程無(wú)創(chuàng)正壓通氣(CPAP)治療前后血清髓過(guò)氧化物酶(MPO)、胰淀素的水平測(cè)定及意義。方法:87例OSAHS患者根據(jù)AHI分為重度組(30例)、中度組(30例)、輕度組(27例);以門(mén)診健康者27例為對(duì)照組。采用ELISA法測(cè)定受試者血清MPO和胰淀素。30例重度OSAHS患者行CPAP治療3個(gè)月和6個(gè)月復(fù)測(cè)MPO、胰淀素,分析MPO、胰淀素與PSG指標(biāo)的關(guān)系。結(jié)果:(1)隨著OSAHS病情程度增加,血MPO、胰淀素水平均逐漸上升(F=22.486,19.755;P0.01);其中輕度組與對(duì)照組MPO、胰淀素濃度差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),余各間相互比較均有明顯差別(P0.01)。(2)OSAHS患者血清MPO、胰淀素水平和BMI、年齡沒(méi)有關(guān)聯(lián)(P0.05),與LSaO_2呈負(fù)相關(guān),和AHI呈正相關(guān)(P0.01);血MPO與胰淀素水平呈正相關(guān)(r=0.466,P0.01)。(3)30例重度患者經(jīng)CPAP治療3個(gè)月LSaO_2較前上升,AHI及外周血MPO、胰淀素水平較前降低(P0.01);治療6個(gè)月MPO、胰淀素水平較治療3個(gè)月降低(P0.05),但與對(duì)照組比較仍有升高(P0.05)。結(jié)論:聯(lián)合測(cè)定成人OSAHS患者血清胰淀素、MPO濃度對(duì)病情、療效的判斷及并發(fā)糖尿病及胰島素抵抗危險(xiǎn)性預(yù)測(cè)有一定參考價(jià)值。CPAP治療可明顯降低OSAHS患者缺氧程度和胰島功能損害,其療效和療程相關(guān)。
[Abstract]:Objective: to investigate the serum myeloperoxidase (MPO) in adult patients with OSAHS before and after treatment. Methods Eighty-seven patients with OSAHS were divided into severe group (n = 30), moderate group (n = 30) and mild group (n = 27) according to AHI. The serum MPO and amylin in 30 patients with severe OSAHS were measured by ELISA method. MPO was measured in 3 and 6 months after CPAP treatment. Amylin, analysis of the relationship between OSAHS, amylin and PSG index. Results: with the increase of the degree of OSAHS, the levels of plasma MPO and amylin increased gradually. 19.755; P0.01; There was no significant difference in MPO and amylin concentrations between mild group and control group (P 0.05). There were significant differences in serum MPO, amylin levels and BMI. there was no correlation between the age of MPO and amylin in patients with OSAHS (P0.05). There was a negative correlation with LSaO_2 and a positive correlation with AHI (P 0.01). There was a positive correlation between serum MPO and amylin levels in 30 cases of severe patients treated with CPAP for 3 months. The levels of AHI, MPO and amylin in peripheral blood were significantly lower than those in control group (P 0.01). After 6 months of treatment with MPO, the level of amylin was lower than that of 3 months (P 0.05). Conclusion: combined determination of serum amylin and amylin in adult patients with OSAHS is effective in the treatment of the disease. The evaluation of curative effect and risk prediction of diabetes mellitus and insulin resistance have certain reference value. CPAP treatment can significantly reduce the degree of hypoxia and islet function damage in patients with OSAHS, and its curative effect is related to the course of treatment.
【作者單位】： 中山大學(xué)附屬第八醫(yī)院(深圳福田)耳鼻咽喉頭頸外科;深圳市第七人民醫(yī)院檢驗(yàn)科;
【分類(lèi)號(hào)】：R766
【正文快照】： OSAHS患者可合并糖代謝紊亂,早期常表現(xiàn)為胰島素抵抗[1],但具體機(jī)制尚未明了。研究認(rèn)為[2],OSAHS患者間斷缺氧致機(jī)體氧化應(yīng)激增加的病理過(guò)程在合并全身多器官損害的機(jī)制中作用重大。胰島組織抗氧化酶含量很低,其內(nèi)胰島細(xì)胞對(duì)氧化應(yīng)激反應(yīng)十分敏感[3]。髓過(guò)氧化物酶(MPO)是一種，

本文編號(hào)：1472217