本文關(guān)鍵詞： 阻塞性睡眠呼吸暫停低通氣綜合征 高敏C反應(yīng)蛋白 白介素-　出處：《慢性病學(xué)雜志》2016年10期 　論文類型：期刊論文

【摘要】：目的探討老年阻塞性睡眠呼吸暫停低通氣綜合征(OSAHS)患者血清中高敏C反應(yīng)蛋白(hsCRP)和白介素-6(IL-6)水平檢測的臨床意義。方法選取2014年4月—2016年3月青島市第八人民醫(yī)院收治的137例OSAHS患者作為觀察組,另外選取50例同期健康體檢者作為對照組,采用免疫比濁法檢測兩組血清中hs-CRP水平,采用酶聯(lián)吸附法(ELISA)檢測IL-6水平;對OSAHS患者行持續(xù)氣道正壓通氣(CPAP)治療,比較治療前后其血清中hs-CRP和IL-6水平;并采用SPSS18.0統(tǒng)計學(xué)軟件分析,計量資料以均數(shù)±標(biāo)準(zhǔn)差(xˉ±s)表示,采用t檢驗,多組間比較采用方差分析,P0.05為差異有統(tǒng)計學(xué)意義。結(jié)果觀察組患者血清中hs-CRP、IL-6水平均明顯高于對照組,且觀察組患者血清中hsCRP、IL-6水平隨病情程度加重而升高,差異均有統(tǒng)計學(xué)意義(P0.05);治療后觀察組患者血清中hsCRP、IL-6水平及呼吸暫停低通氣指數(shù)(AHI)均較治療前明顯降低,最低血氧飽和度(LSp O2)較治療前明顯升高,差異均有統(tǒng)計學(xué)意義(P0.05)。結(jié)論 OSAHS患者血清hs-CRP和IL-6水平檢測有助于判斷病情嚴(yán)重程度,且利于指導(dǎo)其臨床治療及判斷預(yù)后。
[Abstract]:Objective to investigate the serum Gao Min C-reactive protein hsCRP (hsCRP) and interleukin-6 (IL-6) in elderly patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods from April 2014 to March 2016, 137 patients with OSAHS in Qingdao 8th people's Hospital were selected as observation group. In addition, 50 healthy persons were selected as the control group. The serum hs-CRP level was detected by immunoturbidimetry, and the IL-6 level was detected by enzyme linked adsorption assay (Elisa). Patients with OSAHS were treated with continuous positive airway pressure (CPAP). The serum levels of hs-CRP and IL-6 were compared before and after treatment. The data were expressed as mean 鹵standard deviation, t test and ANOVA were used in multigroup comparison. Results the serum levels of hs-CRPnIL-6 in the observation group were significantly higher than those in the control group, and the serum hsCRP in the observation group was significantly higher than that in the control group. The level of IL-6 increased with the severity of the disease, and the difference was statistically significant (P 0.05). After treatment, the serum levels of hsCRP IL-6 and apnea hypopnea index (AHII) in the observation group were significantly lower than those before treatment. The lowest oxygen saturation (LSp O 2) was significantly higher than that before treatment. Conclusion the detection of serum hs-CRP and IL-6 levels in patients with OSAHS is helpful to judge the severity of the disease. It is helpful to guide its clinical treatment and judge its prognosis.
【作者單位】： 青島市第八人民醫(yī)院;
【分類號】：R766
【正文快照】： 阻塞性睡眠呼吸暫停低通氣綜合征(OSAHS)是多種因素導(dǎo)致的睡眠過程中上氣道阻塞,反復(fù)出現(xiàn)呼吸變淺或暫停及間斷發(fā)生的低氧血癥和睡眠結(jié)構(gòu)破壞為特征的一種危險性大、發(fā)病率高的睡眠呼吸障礙疾病。該病多發(fā)于老年人,65歲以上老人的發(fā)病率超過20%[1],OSAHS易導(dǎo)致高血壓、冠心病，

本文編號：1455814