本文關鍵詞：手術干預對OSAHS合并代謝綜合征患者血壓、血脂及多種激素水平的影響　出處：《寧夏醫(yī)科大學》2015年碩士論文　論文類型：學位論文

  更多相關文章： 手術 OSAHS 代謝綜合癥 激素水平

【摘要】：目的探究手術干預對阻塞性睡眠呼吸暫停低通氣綜合征(OSAH)合并代謝綜合征(MS)患者血壓、血脂及多種激素水平的影響情況,為患者的治療提供臨床理論依據(jù)。方法選取2013年1月至2014年10月于寧夏醫(yī)科大學總醫(yī)院心腦血管病醫(yī)院接受治療的OSAHS合并代謝綜合征患者35例,觀察手術治療前后患者血壓、血脂、血糖、胰島素抵抗、甲狀腺功能、生長激素及性激素水平情況,并將觀察組分為輕、中、重三組,分別比較治療前后三組患者的生理指標以及睡眠質(zhì)量和生活質(zhì)量情況。結果治療后,患者的體重指數(shù)、收縮壓、舒張壓、腹圍和頸圍均小于治療前,差異有統(tǒng)計學意義(P0.05);除高密度脂蛋白膽固醇外,治療后空腹血糖、血漿胰島素、胰島素抵抗、尿酸、甘油三酯、低密度脂蛋白、總膽固醇各項生化指標均低于治療前,差異有統(tǒng)計學意義(P0.05);尚不能認為三碘甲狀腺原氨酸、甲狀腺素、促甲狀腺激素、生長激素手術前后有差異(P0.05)。手術治療后睪酮水平大于治療前,差異有統(tǒng)計學意義(P0.05);手術治療后患者呼吸紊亂指數(shù)(AHI)低于治療前,差異有統(tǒng)計學意義(P0.05);經(jīng)過手術治療后,觀察組(ESS)評分,以及日、夜間主觀癥狀的評分均低于治療前,(P0.05);輕度、中度及重度患者的生活質(zhì)量評分比較差異有統(tǒng)計學意義(P0.05)。結論應用手術干預,能夠顯著改善OSAHS合并MS患者體重、血壓、血糖和性激素等指標,有效提高患者的睡眠質(zhì)量,改善患者的生活質(zhì)量,值得推廣應用。
[Abstract]:Objective to explore the surgical intervention on obstructive sleep apnea hypopnea syndrome (OSAH) patients with metabolic syndrome (MS) patients with blood pressure, blood lipid and effect of several kinds of hormones, to provide theoretical basis for clinical treatment. Methods from January 2013 to October 2014 in the General Hospital of Ningxia Medical University of cardiovascular and cerebrovascular disease treated by OSAHS 35 cases with metabolic syndrome were observed before and after surgery in the patients' blood pressure, blood lipid, blood glucose, insulin resistance, thyroid function, hormone and sex hormone levels of growth, and the observation group divided into light, heavy, three groups were compared before and after treatment of physiological indexes of the three groups of patients and the quality of sleep and quality of life. Results after treatment, the patient's body mass index, systolic blood pressure, diastolic blood pressure, waist and neck are less than before treatment, the difference was statistically significant (P0.05); in addition to high density lipoprotein cholesterol After treatment, fasting blood glucose, plasma insulin, insulin resistance, uric acid, triglyceride, low density lipoprotein cholesterol, total biochemical indexes were lower than those before treatment, the difference was statistically significant (P0.05); it is not considered three triiodothyronine, thyroxine, thyroid stimulating hormone, growth hormone before and after surgery there are differences (P0.05). Testosterone levels than treatment after surgical treatment before, the difference was statistically significant (P0.05); patients with respiratory disturbance index after surgery (AHI) lower than that before treatment, the difference was statistically significant (P0.05); after surgical treatment, the observation group (ESS) score, and on the night, subjective symptom scores were lower than the treatment before (P0.05); mild, significant quality of life score in patients with moderate and severe differences (P0.05). Conclusion the application of surgical intervention can significantly improve patients with OSAHS MS body weight, blood pressure, blood glucose and hormone etc. Index, effectively improve the quality of the patients' sleep and improve the quality of life of the patients, it is worth popularizing.

【學位授予單位】：寧夏醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R766;R589

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