本文關鍵詞：Survivin及Bcl-2在鼻腔鼻竇鱗狀細胞癌中的表達及意義　出處：《臨床耳鼻咽喉頭頸外科雜志》2016年07期 　論文類型：期刊論文

  更多相關文章： 鼻腔 鼻竇 癌 鱗狀細胞 Survivin Bcl-

【摘要】：目的:探討凋亡相關蛋白Survivin及Bcl-2在鼻腔鼻竇鱗狀細胞癌(SNSCC)中的表達及臨床意義。方法:采用免疫組織化學Envision二步法檢測35例SNSCC及20例正常下鼻甲黏膜標本中Survivin和Bcl-2的表達。結果:Survivin在SNSCC組織中的表達為88.6%,在正常下鼻甲黏膜組織無表達,二者差異有統(tǒng)計學意義(P0.01)。Bcl-2在SNSCC組織中的表達為71.4%,明顯高于正常下鼻甲黏膜組織的表達25%(P0.01)。Survivin與Bcl-2的表達呈正相關(P0.01)。腫瘤的分級程度越高,Survivin和Bcl-2的表達水平越低。結論:Survivin、Bcl-2與SNSCC的發(fā)生、發(fā)展有關,Survivin可能會成為SNSCC基因治療的靶點。
[Abstract]:Objective: To investigate the expression of apoptosis related protein Survivin and Bcl-2 in nasal sinus squamous cell carcinoma (SNSCC) and its clinical significance. Methods: immunohistochemical Envision two step method was used to detect the expression of Survivin and Bcl-2 in 35 cases of SNSCC and 20 cases of normal inferior turbinate mucous membrane. Results: the expression of Survivin in SNSCC tissue was 88.6%, and there was no expression in normal inferior turbinate mucosa, and the difference between the two groups was statistically significant (P0.01). The expression of Bcl-2 in SNSCC tissue was 71.4%, which was significantly higher than that of normal inferior turbinate mucosa (25% (P0.01)). The expression of Survivin was positively correlated with the expression of Bcl-2 (P0.01). The higher the level of the tumor, the lower the expression level of Survivin and Bcl-2. Conclusion: Survivin and Bcl-2 are related to the occurrence and development of SNSCC, and Survivin may be the target of SNSCC gene therapy.
【作者單位】： 漢中市中心醫(yī)院耳鼻咽喉頭頸外科;漢中市中心醫(yī)院病理科;
【分類號】：R739.62
【正文快照】： synthase(iNOS)[J].Clin Epigenetics,2012,4:3-3.[16]KWON N H,KIM J S,LEE J Y,et al.DNA methyl-ation and the expression of IL-4and IFN-gamma pro-moter genes in patients with bronchial asthma[J].JClin Immunol,2008,28:139-146.[17]SOFER T,BACCARELLI A,CANTONE

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