力學(xué)載荷促進(jìn)軟骨傳質(zhì)的仿真研究
發(fā)布時(shí)間：2019-06-17 08:48
【摘要】：關(guān)節(jié)軟骨呈乳白淡藍(lán)色,表面光滑且半透明,有光澤,具有多種多樣無(wú)可替代的獨(dú)特功能和重要作用。但是關(guān)節(jié)軟骨是臨床疾病多發(fā)部位,并且關(guān)節(jié)軟骨自身恢復(fù)能力低。關(guān)節(jié)軟骨缺損經(jīng)常造成關(guān)節(jié)功能障礙等疾病,從而影響人們的正常活動(dòng)和日常生活。故對(duì)軟骨傳質(zhì)的研究成為了國(guó)內(nèi)外的熱點(diǎn)。正常軟骨的傳質(zhì)過(guò)程需要在一定的外界載荷作用下進(jìn)行。本文采用有限元數(shù)值模擬分析關(guān)節(jié)軟骨在力學(xué)載荷作用下的傳質(zhì),根據(jù)仿真結(jié)果研究不同載荷作用下傳質(zhì)的規(guī)律,為臨床疾病治療和組織修復(fù)等提供科學(xué)依據(jù)。根據(jù)傳質(zhì)理論中的斐克第二定律,質(zhì)量守恒定律以及傳熱和傳質(zhì)在數(shù)值上的等效,提出了軟骨傳質(zhì)的仿真方案,運(yùn)用有限元軟件ANSYS建立軟骨模型,對(duì)模型施加靜態(tài)壓縮,并將仿真結(jié)果與實(shí)驗(yàn)結(jié)果對(duì)比,兩者具有較好的相關(guān)性,表明了模擬方法的正確性�；陟o態(tài)壓縮時(shí)的仿真模型,研究動(dòng)態(tài)壓縮對(duì)軟骨傳質(zhì)的影響以及動(dòng)態(tài)壓縮參數(shù)對(duì)傳質(zhì)的影響。結(jié)果表明:①軟骨施加載荷之后,軟骨傳質(zhì)速度比靜置時(shí)加快了很多。②動(dòng)態(tài)壓縮載荷作用下,在初期軟骨傳質(zhì)在深層和中間層的速度十分緩慢,而淺表層的傳質(zhì)速度很快,但隨著時(shí)間的增加,淺表層濃度增長(zhǎng)緩慢,趨于穩(wěn)定的濃度值,而中間層和深層增速加快。③壓縮幅值相同時(shí),靜態(tài)壓縮與動(dòng)態(tài)壓縮相比,軟骨內(nèi)部溶質(zhì)更容易擴(kuò)散。④動(dòng)態(tài)壓縮振幅增加時(shí),軟骨內(nèi)溶質(zhì)濃度隨時(shí)間均為上升趨勢(shì),淺表層增加明顯,但隨著幅值的增加,溶質(zhì)擴(kuò)散受到抑制,且幅值越大,抑制作用越明顯。⑤動(dòng)態(tài)壓縮頻率增加,有利于軟骨各層溶質(zhì)擴(kuò)散,頻率越大,擴(kuò)散速度增加越明顯,淺表層變化明顯。對(duì)滑動(dòng)載荷作用下軟骨傳質(zhì)規(guī)律進(jìn)行研究,得出以下結(jié)論:①在初期軟骨傳質(zhì)在深層的速度相對(duì)緩慢,而在中間層和淺表層的傳質(zhì)速度較快。但隨著時(shí)間的增加,淺表層濃度增長(zhǎng)緩慢,趨于穩(wěn)定的濃度值,中間層增速也有所下降,然而深層傳質(zhì)速度的增加十分明顯。②滑動(dòng)載荷作用壓縮量增加時(shí),軟骨內(nèi)溶質(zhì)濃度隨時(shí)間均為上升趨勢(shì),但隨著壓縮量的增加,對(duì)溶質(zhì)擴(kuò)散有抑制作用,其中中間層的抑制作用最大,深層的抑制作用最小。③滑動(dòng)速度的增加,有利于軟骨各層溶質(zhì)擴(kuò)散,其中中間層和深層的擴(kuò)散速度增加十分明顯。仿真結(jié)果為今后進(jìn)一步研究提供了一定的理論基礎(chǔ)。研究不同模型對(duì)仿真結(jié)果的影響,發(fā)現(xiàn):①在運(yùn)用ANSYS進(jìn)行仿真時(shí),分層和不分層對(duì)軟骨傳質(zhì)研究的影響很小。為了操作簡(jiǎn)便,提高效率,可以不對(duì)軟骨進(jìn)行分層。②在運(yùn)用ANSYS進(jìn)行仿真時(shí),三維模型與二維模型存在差異,由于三維模型的建立和載荷的施加更接近于真實(shí)情況,所以在研究軟骨傳質(zhì)時(shí),應(yīng)優(yōu)先考慮三維模型,提高計(jì)算的準(zhǔn)確度。仿真結(jié)果為下一步仿真模擬時(shí)模型的選擇提供了一定的基礎(chǔ)。
[Abstract]:The articular cartilage is milky white and light blue, the surface is smooth and translucent, has a luster, and has a variety of irreplaceable unique functions and important functions. But the joint cartilage is a multiple part of the clinical disease, and the self-recovery ability of the joint cartilage is low. Joint cartilage defects often cause joint dysfunction and other diseases, thus affecting the normal activity and daily life of people. Therefore, the study of mass transfer of cartilage has become a hot spot at home and abroad. The mass transfer process of the normal cartilage needs to be carried out under a certain external load. In this paper, the mass transfer of the articular cartilage under the action of mechanical load is analyzed by the finite element method, and the law of mass transfer under different loads is studied according to the simulation results, and the scientific basis for clinical disease treatment and tissue repair is provided. According to the Fick's second law in mass transfer theory, the law of mass conservation and the equivalent of heat transfer and mass transfer on the numerical value, the simulation program of the mass transfer of the cartilage was put forward. The model of the cartilage was set up by using the finite element software ANSYS, the static compression was applied to the model, and the simulation results were compared with the experimental results. The results show that the simulation method is correct. The effects of dynamic compression on mass transfer and the effect of dynamic compression on mass transfer are studied based on the simulation model of static compression. The results showed that the mass transfer rate of cartilage was much faster than that of standing. Under the effect of dynamic compressive load, the velocity of mass transfer at the initial stage in the deep layer and the middle layer is very slow, while the mass transfer speed of the shallow surface layer is very fast, but with the increase of time, the concentration of the shallow surface layer grows slowly and is stable, and the middle layer and the deep layer increase rapidly. When the compression amplitude is the same, the static compression is easier to spread than the dynamic compression. When the dynamic compression amplitude of the cartilage is increased, the concentration of the solute in the cartilage increases with the time, the superficial layer is obviously increased, but with the increase of the amplitude, the solute diffusion is inhibited, and the larger the amplitude, the more obvious the inhibition effect. The dynamic compression frequency of the cartilage is increased, which is beneficial to the diffusion of the solute in the layers of the cartilage, the higher the frequency, the more obvious the increase of the diffusion speed, and the obvious change of the superficial layer. It is concluded that the mass transfer of cartilage in the initial stage is relatively slow at the initial stage, and the mass transfer rate between the intermediate layer and the shallow surface layer is fast. However, with the increase of time, the growth of the shallow surface layer is slow, the concentration value of the stabilization is stable, and the growth of the intermediate layer is also decreased, but the increase of the deep mass transfer rate is very obvious. In addition, the concentration of the solute in the cartilage increases with time, but with the increase of the amount of compression, the inhibition of solute diffusion is inhibited, and the inhibition of the intermediate layer is the largest and the inhibition of the deep layer is the least. The increase of the sliding speed of the cartilage is beneficial to the diffusion of the solute in each layer of the cartilage, and the diffusion speed of the middle layer and the deep layer is obviously increased. The simulation results provide a theoretical basis for further research in the future. The effects of different models on the simulation results are studied. In order to be simple and convenient to operate, the efficiency can be improved, and the cartilage can not be layered. In the case of simulation by using ANSYS, the three-dimensional model is different from the two-dimensional model. Because the establishment of the three-dimensional model and the application of the load are closer to the real situation, the three-dimensional model should be taken into consideration when studying the mass transfer of the cartilage, and the accuracy of the calculation is improved. The simulation results provide a basis for the selection of the model when the next simulation is simulated.
【學(xué)位授予單位】：天津理工大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R684;TP391.9
本文編號(hào)：2500864
[Abstract]:The articular cartilage is milky white and light blue, the surface is smooth and translucent, has a luster, and has a variety of irreplaceable unique functions and important functions. But the joint cartilage is a multiple part of the clinical disease, and the self-recovery ability of the joint cartilage is low. Joint cartilage defects often cause joint dysfunction and other diseases, thus affecting the normal activity and daily life of people. Therefore, the study of mass transfer of cartilage has become a hot spot at home and abroad. The mass transfer process of the normal cartilage needs to be carried out under a certain external load. In this paper, the mass transfer of the articular cartilage under the action of mechanical load is analyzed by the finite element method, and the law of mass transfer under different loads is studied according to the simulation results, and the scientific basis for clinical disease treatment and tissue repair is provided. According to the Fick's second law in mass transfer theory, the law of mass conservation and the equivalent of heat transfer and mass transfer on the numerical value, the simulation program of the mass transfer of the cartilage was put forward. The model of the cartilage was set up by using the finite element software ANSYS, the static compression was applied to the model, and the simulation results were compared with the experimental results. The results show that the simulation method is correct. The effects of dynamic compression on mass transfer and the effect of dynamic compression on mass transfer are studied based on the simulation model of static compression. The results showed that the mass transfer rate of cartilage was much faster than that of standing. Under the effect of dynamic compressive load, the velocity of mass transfer at the initial stage in the deep layer and the middle layer is very slow, while the mass transfer speed of the shallow surface layer is very fast, but with the increase of time, the concentration of the shallow surface layer grows slowly and is stable, and the middle layer and the deep layer increase rapidly. When the compression amplitude is the same, the static compression is easier to spread than the dynamic compression. When the dynamic compression amplitude of the cartilage is increased, the concentration of the solute in the cartilage increases with the time, the superficial layer is obviously increased, but with the increase of the amplitude, the solute diffusion is inhibited, and the larger the amplitude, the more obvious the inhibition effect. The dynamic compression frequency of the cartilage is increased, which is beneficial to the diffusion of the solute in the layers of the cartilage, the higher the frequency, the more obvious the increase of the diffusion speed, and the obvious change of the superficial layer. It is concluded that the mass transfer of cartilage in the initial stage is relatively slow at the initial stage, and the mass transfer rate between the intermediate layer and the shallow surface layer is fast. However, with the increase of time, the growth of the shallow surface layer is slow, the concentration value of the stabilization is stable, and the growth of the intermediate layer is also decreased, but the increase of the deep mass transfer rate is very obvious. In addition, the concentration of the solute in the cartilage increases with time, but with the increase of the amount of compression, the inhibition of solute diffusion is inhibited, and the inhibition of the intermediate layer is the largest and the inhibition of the deep layer is the least. The increase of the sliding speed of the cartilage is beneficial to the diffusion of the solute in each layer of the cartilage, and the diffusion speed of the middle layer and the deep layer is obviously increased. The simulation results provide a theoretical basis for further research in the future. The effects of different models on the simulation results are studied. In order to be simple and convenient to operate, the efficiency can be improved, and the cartilage can not be layered. In the case of simulation by using ANSYS, the three-dimensional model is different from the two-dimensional model. Because the establishment of the three-dimensional model and the application of the load are closer to the real situation, the three-dimensional model should be taken into consideration when studying the mass transfer of the cartilage, and the accuracy of the calculation is improved. The simulation results provide a basis for the selection of the model when the next simulation is simulated.
【學(xué)位授予單位】：天津理工大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R684;TP391.9
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