【摘要】：目的探討神經(jīng)顆粒素(neurograinin,NG)作為急性顱腦損傷(traumatic injury,TBI)患者外周循環(huán)標(biāo)志物的臨床意義。方法收集無錫市101醫(yī)院急診收治的TBI患者71例,經(jīng)頭顱電子計算機斷層掃描(CT)或磁共振成像(MRI)檢查確診,以85例無錫市中醫(yī)醫(yī)院體檢正常者作為正常對照組。用ELISA雙抗體夾心法檢測TBI患者和正常對照組外周血中NG水平,采用凝固法檢測凝血酶原時間(PT)、纖維蛋白原(Fib),采用膠乳增強免疫比濁法檢測C反應(yīng)蛋白(CRP),用全自動五分類血液分析儀檢測血小板(PLT)數(shù)量。結(jié)果 TBI患者血清NG水平為850.51(647.96,962.11)pg/m L,正常對照組血清NG水平為612.44(534.44,733.9)pg/m L,TBI患者血清NG水平顯著高于正常對照組(U=36.146,P=0.000)。中型和重型TBI患者NG水平高于輕型TBI患者,但差異無統(tǒng)計學(xué)意義(P0.05)。原發(fā)性顱腦損傷組血清NG水平高于繼發(fā)性顱腦損傷組,但差異無統(tǒng)計學(xué)意義(P0.05)。TBI患者的年齡、性別、Glasgow積分與血清NG水平無直接關(guān)系,而PLT、PT、國際化標(biāo)準(zhǔn)比率(INR)及CRP則是影響NG的主要因素。結(jié)論 NG在TBI患者血清中的表達(dá)升高,該指標(biāo)聯(lián)合凝血功能檢測可能對判斷TBI患者嚴(yán)重程度和進展具有一定意義。
[Abstract]:Objective to investigate the clinical significance of neurogranin (neurograinin,NG) as a marker of peripheral circulation in patients with acute craniocerebral injury (traumatic injury,TBI). Methods 71 patients with TBI were diagnosed by (CT) or magnetic resonance imaging (MRI) in Wuxi 101 Hospital. 85 patients with normal physical examination in Wuxi Hospital of traditional Chinese Medicine were used as normal control group. The level of NG in peripheral blood of TBI patients and normal control group was detected by ELISA double antibody sandwich method, and the prothrombin time (PT), fibrin (Fib), was detected by coagulation method. C-reactive protein (CRP), was detected by latex enhanced immunoturbidimetry. The number of platelet (PLT) was measured by automatic five-classification blood analyzer. Results the serum NG level of TBI patients was 850.51 (647.96962.11) pg/m / L, and that of normal control group was 612.44 (534.44733.9) pg/m / L. The serum NG level of TBI patients was significantly higher than that of normal control group (U 鈮，

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