發(fā)布時(shí)間：2019-05-14 08:36

【摘要】：目的探討開顱手術(shù)術(shù)后炎癥因子水平變化預(yù)測(cè)顱內(nèi)感染的價(jià)值。方法回顧性分析2012年1月至2015年1月收治的48例開顱手術(shù)患者,術(shù)后經(jīng)腦脊液等輔助檢查證實(shí)為顱內(nèi)感染的作為研究組,選取同時(shí)期開顱手術(shù)無顱內(nèi)感染患者48例作為對(duì)照組,兩組均抽取靜脈血,觀察炎癥指標(biāo)變化情況。結(jié)果術(shù)后第1天兩組白細(xì)胞(WBC)、白細(xì)胞介素(IL)-6、腫瘤壞死因子(TNF)-α、人S-100b蛋白(S-100b)、C反應(yīng)蛋白(CRP)、降鈣素原(PCT)比較差異無統(tǒng)計(jì)學(xué)意義(均P0.05),而術(shù)后第3天開始研究組WBC、IL-6、TNF-α、S-100b、CRP、PCT水平顯著高于對(duì)照組,術(shù)后第7、14天兩組差異越來越大(均P0.05);經(jīng)顱內(nèi)感染受試者工作特征(ROC)曲線分析,WBC、IL-6、TNF-α、S-100b、CRP、PCT對(duì)顱內(nèi)感染差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論開顱手術(shù)后3 d WBC、IL-6、TNF-α、S-100b、CRP、PCT水平無下降則預(yù)示患者術(shù)后顱內(nèi)感染可能性大。
[Abstract]:Objective to evaluate the value of inflammatory factors in predicting intracranial infection after craniotomy. Methods from January 2012 to January 2015, 48 patients undergoing craniotomy were analyzed retrospectively. the patients with intracranial infection confirmed by cerebrospinal fluid and other auxiliary examination were used as the study group, and 48 patients without intracranial infection during the same period were selected as the control group. Venous blood was taken from both groups to observe the changes of inflammatory indexes. Results on the first day after operation, (WBC), (IL)-6, tumor necrosis factor (TNF)-偽 and human S 鈮，

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