尤因肉瘤中NKX2.2的表達及其診斷意義
發(fā)布時間：2019-04-23 19:45
【摘要】：目的探討NKX2.2在尤因肉瘤(Ewing’s sarcoma,ES)中的表達及與其它小圓細胞腫瘤的鑒別診斷價值。方法采用免疫組化En Vision兩步法檢測49例ES組織和43例其它小圓細胞惡性腫瘤中NKX2.2、CD99及FLI1的表達,分析NKX2.2并聯(lián)合其它指標在ES診斷中的敏感性和特異性。結(jié)果 NKX2.2在ES中的陽性率為71.43%(35/49),在其它小圓細胞腫瘤中陽性率為9.30%(4/43);NKX2.2在ES中表達的敏感性和特異性分別為71.43%和90.70%。CD99在ES中表達的敏感性和特異性分別為100%和23.26%,FLI1在ES中表達的敏感性和特異性分別為87.76%和30.23%。聯(lián)合檢測NKX2.2與CD99及FLI1對ES診斷的敏感性和特異性分別為65.31%和100%。結(jié)論 NKX2.2蛋白是ES診斷和鑒別診斷中有用的標志物,聯(lián)合檢測三者有助于ES與其它小圓細胞腫瘤的鑒別。
[Abstract]:Objective to investigate the expression of NKX2.2 in Eine sarcoma (Ewing's sarcoma,ES) and its differential diagnosis from other small round cell tumors. Methods Immunohistochemical En Vision two-step method was used to detect the expression of NKX2.2,CD99 and FLI1 in 49 cases of ES and 43 cases of other small round cell malignant tumors. The sensitivity and specificity of NKX2.2 combined with other markers in the diagnosis of ES were analyzed. Results the positive rate of NKX2.2 was 71.43% (35 / 49) in ES and 9.30% (4 / 43) in other small round cell tumors. The sensitivity and specificity of NKX2.2 expression in ES was 71.43% and that of 90.70%.CD99 in ES was 100% and 23.26%, respectively. The sensitivity and specificity of FLI1 expression in ES were 87.76% and 30.23%, respectively. The sensitivity and specificity of combined detection of NKX2.2, CD99 and FLI1 in the diagnosis of ES were 65.31% and 100%, respectively. Conclusion NKX2.2 protein is a useful marker in the diagnosis and differential diagnosis of ES. The combined detection of ES protein is helpful to differentiate ES from other small round cell tumors.
【作者單位】： 北京大學(xué)醫(yī)學(xué)部病理學(xué)系/北京大學(xué)第三醫(yī)院病理科;
【基金】：國家自然科學(xué)基金(81272945) 北京市自然科學(xué)基金(7122100)
【分類號】：R738.6
本文編號：2463744
[Abstract]:Objective to investigate the expression of NKX2.2 in Eine sarcoma (Ewing's sarcoma,ES) and its differential diagnosis from other small round cell tumors. Methods Immunohistochemical En Vision two-step method was used to detect the expression of NKX2.2,CD99 and FLI1 in 49 cases of ES and 43 cases of other small round cell malignant tumors. The sensitivity and specificity of NKX2.2 combined with other markers in the diagnosis of ES were analyzed. Results the positive rate of NKX2.2 was 71.43% (35 / 49) in ES and 9.30% (4 / 43) in other small round cell tumors. The sensitivity and specificity of NKX2.2 expression in ES was 71.43% and that of 90.70%.CD99 in ES was 100% and 23.26%, respectively. The sensitivity and specificity of FLI1 expression in ES were 87.76% and 30.23%, respectively. The sensitivity and specificity of combined detection of NKX2.2, CD99 and FLI1 in the diagnosis of ES were 65.31% and 100%, respectively. Conclusion NKX2.2 protein is a useful marker in the diagnosis and differential diagnosis of ES. The combined detection of ES protein is helpful to differentiate ES from other small round cell tumors.
【作者單位】： 北京大學(xué)醫(yī)學(xué)部病理學(xué)系/北京大學(xué)第三醫(yī)院病理科;
【基金】：國家自然科學(xué)基金(81272945) 北京市自然科學(xué)基金(7122100)
【分類號】：R738.6
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