疝修復(fù)用紡織基補(bǔ)片的結(jié)構(gòu)與性能研究
發(fā)布時(shí)間：2019-03-20 14:38
【摘要】：人體腹壁作為一種動(dòng)態(tài)系統(tǒng)，可以抵抗腹腔內(nèi)的持續(xù)壓力和突變壓力，補(bǔ)片植入人體后，在腹壁正常活動(dòng)下將持續(xù)承受一定壓力，并被反復(fù)彎折。因此，作為腹壁增強(qiáng)材料，補(bǔ)片應(yīng)能在動(dòng)態(tài)壓力下具有足夠的強(qiáng)度及力學(xué)穩(wěn)定性。聚丙烯（polypropylene，PP）是一種廣泛應(yīng)用于疝修復(fù)手術(shù)中的合成材料，PP補(bǔ)片具有豐富的紡織結(jié)構(gòu)、規(guī)格和形態(tài)，其不同的物理力學(xué)性能，與各種術(shù)后并發(fā)癥密切相關(guān)。為此紡織基補(bǔ)片的結(jié)構(gòu)與性能的內(nèi)在關(guān)系值得深入分析與研究，目前，，國(guó)內(nèi)外尚鮮有詳細(xì)報(bào)道。 本研究將對(duì)9種臨床常用的進(jìn)口補(bǔ)片、1種臨床用的國(guó)產(chǎn)補(bǔ)片和1種自主設(shè)計(jì)的國(guó)產(chǎn)補(bǔ)片的原料、結(jié)構(gòu)和性能進(jìn)行測(cè)試、分析與評(píng)價(jià)。具體研究?jī)?nèi)容包括三部分，一是對(duì)國(guó)內(nèi)外PP單絲原料進(jìn)行線密度和力學(xué)性能測(cè)試，分析單絲性能對(duì)補(bǔ)片結(jié)構(gòu)和性能的影響。二是對(duì)11種國(guó)內(nèi)外補(bǔ)片進(jìn)行結(jié)構(gòu)分析測(cè)試，測(cè)試項(xiàng)目包括補(bǔ)片的織造特征、幾何特征和表面形態(tài)等三大類，對(duì)測(cè)試結(jié)果進(jìn)行評(píng)價(jià)，并就與補(bǔ)片臨床愈合密切相關(guān)的孔隙率指標(biāo)進(jìn)行了深入探討。三是選取3種結(jié)構(gòu)相似的國(guó)內(nèi)外補(bǔ)片進(jìn)行力學(xué)性能測(cè)試及物理性能分析測(cè)試，研究補(bǔ)片結(jié)構(gòu)對(duì)其力學(xué)性能特別是疲勞性能的影響。 研究結(jié)果表明，進(jìn)口PP單絲的強(qiáng)度略高于國(guó)產(chǎn)PP，但國(guó)產(chǎn)PP單絲細(xì)度小，更適合編織輕質(zhì)補(bǔ)片；不同結(jié)構(gòu)和單絲直徑的補(bǔ)片樣品，其橫縱向密度各有差異，相比起紡織結(jié)構(gòu)間的差異，補(bǔ)片編織原料單絲的粗細(xì)對(duì)補(bǔ)片的幾何特征影響更大；影響補(bǔ)片強(qiáng)力的主要因素是材料結(jié)晶度、補(bǔ)片幾何結(jié)構(gòu)、微觀結(jié)構(gòu)和裁剪方向，且?guī)讉�(gè)因素之間存在相互對(duì)應(yīng)的影響關(guān)系；PP補(bǔ)片經(jīng)過(guò)反復(fù)拉伸后受到明顯的疲勞損傷，要根據(jù)不同強(qiáng)力和伸長(zhǎng)要求，相應(yīng)變換補(bǔ)片裁剪和放置方向；PP補(bǔ)片的正反面剛度有差異，臨床使用時(shí)需注意方向性。 針對(duì)PP補(bǔ)片在臨床中使用時(shí)易與內(nèi)臟發(fā)生粘連的情況，在進(jìn)行國(guó)內(nèi)外補(bǔ)片性能分析測(cè)試的基礎(chǔ)上，綜合比較各類產(chǎn)品，選擇對(duì)自主設(shè)計(jì)的補(bǔ)片進(jìn)行進(jìn)一步改進(jìn)。嘗試以膠原溶液為原料，采用靜電紡技術(shù)，初步探索紡織基抗粘連復(fù)合補(bǔ)片。 綜上所述，課題完成了對(duì)PP補(bǔ)片樣品較為全面的性能測(cè)試與評(píng)價(jià)，分析了補(bǔ)片結(jié)構(gòu)對(duì)性能的影響，并對(duì)防粘連復(fù)合補(bǔ)片的設(shè)計(jì)和制備進(jìn)行了初步探索。研究結(jié)果對(duì)于改善國(guó)產(chǎn)PP產(chǎn)品的設(shè)計(jì)和制備具有一定的參考價(jià)值。
[Abstract]:As a dynamic system, the abdominal wall of the human body can resist the continuous pressure and abrupt pressure in the abdominal cavity. After the patch is implanted into the human body, it will continue to bear a certain pressure under the normal activity of the abdominal wall, and will be bent over and over again. Therefore, as a web wall reinforcement material, the patch should have sufficient strength and mechanical stability under dynamic pressure. Polypropylene (polypropylene,PP) is a synthetic material widely used in hernia repair surgery. PP patch has rich textile structure, specification and shape, and its different physical and mechanical properties are closely related to various postoperative complications. Therefore, the internal relationship between structure and properties of textile base patch is worthy of further analysis and study. At present, there are few detailed reports at home and abroad. In this study, the raw materials, structures and properties of 9 kinds of imported patches, 1 domestic patch for clinical use and 1 kind of homemade patch designed by ourselves were tested, analyzed and evaluated. The main contents include three parts: one is to test the linear density and mechanical properties of PP monofilament materials at home and abroad, and analyze the influence of monofilament properties on the structure and properties of patch. Secondly, the structure analysis and test of 11 kinds of patches at home and abroad are carried out. The testing items include weaving characteristics, geometric features and surface morphology of the patches, and the test results are evaluated. The porosity index which is closely related to the clinical healing of the patch is also discussed in this paper. Thirdly, the mechanical properties and physical properties of three kinds of domestic and foreign patches with similar structures are tested, and the effects of the patch structures on the mechanical properties, especially the fatigue properties, are studied. The results show that the strength of imported PP monofilament is slightly higher than that of domestic PP, but the fineness of domestic PP monofilament is small, so it is more suitable for knitting lightweight patch. The transverse and longitudinal densities of patch samples with different structure and monofilament diameter are different. Compared with the difference between textile structures, the thickness of monofilament has greater influence on the geometric characteristics of patch. The main factors affecting the strength of the patch are the crystallinity of the material, the geometric structure of the patch, the microstructure and the cutting direction, and there is a corresponding influence relationship among the several factors. After repeated stretching, PP patch is obviously damaged by fatigue, so it is necessary to change the direction of cutting and placing of patch according to different strength and elongation requirements, and the stiffness of PP patch is different, so it is necessary to pay attention to direction in clinical use. In view of the adhesion between PP patch and viscera when it is used in clinic, based on the analysis and test of patch performance at home and abroad, various products are compared synthetically, and the self-designed patch is chosen to be further improved. Using collagen solution as raw material and electrospinning technology, the textile-based anti-adhesion composite patch was preliminarily explored. In conclusion, we have completed the comprehensive performance test and evaluation of the PP patch sample, analyzed the influence of the patch structure on the performance, and made a preliminary exploration on the design and preparation of the anti-adhesion composite patch. The research results have certain reference value for improving the design and preparation of domestic PP products.
【學(xué)位授予單位】：東華大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R656.2
本文編號(hào)：2444309
[Abstract]:As a dynamic system, the abdominal wall of the human body can resist the continuous pressure and abrupt pressure in the abdominal cavity. After the patch is implanted into the human body, it will continue to bear a certain pressure under the normal activity of the abdominal wall, and will be bent over and over again. Therefore, as a web wall reinforcement material, the patch should have sufficient strength and mechanical stability under dynamic pressure. Polypropylene (polypropylene,PP) is a synthetic material widely used in hernia repair surgery. PP patch has rich textile structure, specification and shape, and its different physical and mechanical properties are closely related to various postoperative complications. Therefore, the internal relationship between structure and properties of textile base patch is worthy of further analysis and study. At present, there are few detailed reports at home and abroad. In this study, the raw materials, structures and properties of 9 kinds of imported patches, 1 domestic patch for clinical use and 1 kind of homemade patch designed by ourselves were tested, analyzed and evaluated. The main contents include three parts: one is to test the linear density and mechanical properties of PP monofilament materials at home and abroad, and analyze the influence of monofilament properties on the structure and properties of patch. Secondly, the structure analysis and test of 11 kinds of patches at home and abroad are carried out. The testing items include weaving characteristics, geometric features and surface morphology of the patches, and the test results are evaluated. The porosity index which is closely related to the clinical healing of the patch is also discussed in this paper. Thirdly, the mechanical properties and physical properties of three kinds of domestic and foreign patches with similar structures are tested, and the effects of the patch structures on the mechanical properties, especially the fatigue properties, are studied. The results show that the strength of imported PP monofilament is slightly higher than that of domestic PP, but the fineness of domestic PP monofilament is small, so it is more suitable for knitting lightweight patch. The transverse and longitudinal densities of patch samples with different structure and monofilament diameter are different. Compared with the difference between textile structures, the thickness of monofilament has greater influence on the geometric characteristics of patch. The main factors affecting the strength of the patch are the crystallinity of the material, the geometric structure of the patch, the microstructure and the cutting direction, and there is a corresponding influence relationship among the several factors. After repeated stretching, PP patch is obviously damaged by fatigue, so it is necessary to change the direction of cutting and placing of patch according to different strength and elongation requirements, and the stiffness of PP patch is different, so it is necessary to pay attention to direction in clinical use. In view of the adhesion between PP patch and viscera when it is used in clinic, based on the analysis and test of patch performance at home and abroad, various products are compared synthetically, and the self-designed patch is chosen to be further improved. Using collagen solution as raw material and electrospinning technology, the textile-based anti-adhesion composite patch was preliminarily explored. In conclusion, we have completed the comprehensive performance test and evaluation of the PP patch sample, analyzed the influence of the patch structure on the performance, and made a preliminary exploration on the design and preparation of the anti-adhesion composite patch. The research results have certain reference value for improving the design and preparation of domestic PP products.
【學(xué)位授予單位】：東華大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R656.2
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本文編號(hào)：2444309
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