【摘要】：從晶體形貌、礦物物相和化學(xué)成分等角度表征頸椎黃韌帶鈣化,并結(jié)合病理學(xué)探討其病因、形成機(jī)制和鈣化進(jìn)程.研究對(duì)2例頸椎黃韌帶鈣化樣品進(jìn)行了顯微紅外、拉曼、透射電子顯微鏡(TEM)、掃描電子顯微鏡(SEM)和同步輻射X射線衍射(XRD)測(cè)試,結(jié)果表明,鈣化物有柱狀、粒狀、絮狀和球狀4種形態(tài);柱狀和粒狀鈣化呈單晶體,晶形較好、邊界明顯,為三斜晶系二羥焦磷酸鈣;絮狀和球狀鈣化呈納米多晶集合體,主要由B型取代的碳羥磷灰石組成.顯微紅外和拉曼測(cè)試顯示在鈣化集合體中,二羥焦磷酸鈣和碳羥磷灰石2種物相分布不均勻,由中央到外圍呈現(xiàn)碳羥磷灰石不斷減少,二羥焦磷酸鈣不斷增多的含量變化趨勢(shì).通過對(duì)鈣化物晶體、集合體形貌、物相及不同物相分布關(guān)系的分析,本文認(rèn)為,頸椎黃韌帶的鈣化初期,首先形成柱狀和粒狀二羥焦磷酸鈣晶體;鈣化后期,鈣化集合體發(fā)生二羥焦磷酸鈣的分解和碳羥磷灰石晶體的沉積,前者為后者提供物質(zhì)來源;碳羥磷灰石沉積過程中,先由納米級(jí)鈣化物形成絮狀鈣化,后形成球狀鈣化.
[Abstract]:The calcification of cervical ligamentum flavum was characterized by crystal morphology, mineral phase and chemical composition. The etiology, formation mechanism and calcification process of ligamentum flavum were discussed in combination with pathology. Two cases of cervical ligamentum flavum calcification were examined by microinfrared, Raman, transmission electron microscopy (TEM),) scanning electron microscopy (SEM) and synchrotron radiation X-ray diffraction (XRD). The results showed that the calcification was columnar and granular. Flocculent and globular; The columnar and granular calcifications are monocrystalline with good crystal shape and obvious boundary, and the flocculating and globular calcifications are nanocrystalline aggregates, mainly composed of carbon hydroxyapatite substituted by B type. Microscopic infrared and Raman measurements showed that the phase distribution of calcium dihydroxypyrophosphate and carbon-hydroxyapatite was not uniform in calcified aggregates, and the content of calcium dihydroxypyrophosphate was increasing and decreasing from the center to the periphery. Based on the analysis of the distribution of calcified crystals, aggregates, phases and different phases, it is concluded that the columnar and granular calcium dihydroxypyrophosphate crystals were first formed in the early stage of calcification of the ligamentum flavum of the cervical vertebrae. The decomposition of calcium dihydroxypyrophosphate and the deposition of carbon hydroxyapatite crystals occurred in the calcified aggregates in the late period of calcification, the former providing the material source for the latter. In the process of carbon hydroxyapatite deposition, flocculent calcification was first formed by nanometer calcification, then spherical calcification was formed.
【作者單位】： 北京大學(xué)地球與空間科學(xué)學(xué)院礦物環(huán)境功能北京市重點(diǎn)實(shí)驗(yàn)室造山帶與地殼演化教育部重點(diǎn)實(shí)驗(yàn)室;北京大學(xué)第三醫(yī)院骨科;
【基金】：國家自然科學(xué)基金(批準(zhǔn)號(hào):41272048)資助項(xiàng)目
【分類號(hào)】：R681.5
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本文編號(hào)：2420872