【摘要】：目的了解神經(jīng)外科術(shù)后感染患者萬古霉素腦脊液穿透率及影響因素,為臨床治療提供參考依據(jù)。方法選取2015年3月-2016年6月11例開顱術(shù)后感染患者作為研究對象,通過酶放大免疫檢測技術(shù)測定血清和腦脊液中萬古霉素濃度,計(jì)算穿透率及相關(guān)因素。結(jié)果患者萬古霉素平均血清藥物濃度為(9.89±2.97)mg/L,腦脊液濃度為(2.34±1.98)mg/L,穿透率為(0.22±0.16)%;萬古霉素血藥濃度與體重有明顯相關(guān)性(P0.05),與年齡及血肌酐水平不相關(guān);而萬古霉素腦脊液穿透率與腦脊液白細(xì)胞計(jì)數(shù)可能相關(guān)(P0.05),與腦脊液糖濃度及蛋白濃度不相關(guān)。結(jié)論常規(guī)劑量萬古霉素在血及腦脊液中濃度較低,建議根據(jù)患者體重計(jì)算給藥劑量并監(jiān)測萬古霉素血和腦脊液濃度。
[Abstract]:Objective to investigate the penetration rate of vancomycin cerebrospinal fluid (CSF) and its influencing factors in patients with infection after neurosurgery, and to provide reference for clinical treatment. Methods from March 2015 to June 2016, 11 patients with postoperative infection after craniotomy were selected as study subjects. The concentration of vancomycin in serum and cerebrospinal fluid was determined by enzyme amplification immunoassay, and the penetration rate and related factors were calculated. Results the average serum concentration of vancomycin was (9.89 鹵2.97) mg/L, CSF concentration was (2.34 鹵1.98) mg/L, penetration rate was (0.22 鹵0.16)%. The concentration of vancomycin was significantly correlated with body weight (P0.05), but not with age and serum creatinine level. The penetration rate of vancomycin cerebrospinal fluid (CSF) may be correlated with CSF white blood cell count (P0.05), but not with cerebrospinal fluid (CSF) sugar concentration and protein concentration. Conclusion the concentration of vancomycin in blood and cerebrospinal fluid is low. It is suggested to calculate the dosage of vancomycin and monitor the concentration of vancomycin in blood and cerebrospinal fluid according to the weight of patients.
【作者單位】： 西安交通大學(xué)第二附屬醫(yī)院藥學(xué)部;西安交通大學(xué)第二附屬醫(yī)院神經(jīng)外科;西安市農(nóng)產(chǎn)品質(zhì)量安全檢驗(yàn)監(jiān)測中心;
【基金】：西安交通大學(xué)臨床新技術(shù)項(xiàng)目(XJLS-2015-313)
【分類號】：R651
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本文編號：2418244