發(fā)布時(shí)間：2019-01-01 18:32

【摘要】：目的探討T淋巴細(xì)胞亞群及細(xì)胞因子水平變化在骨科醫(yī)院感染患者中的臨床價(jià)值。方法選取2013年1月-2015年12月醫(yī)院收治的50例骨科醫(yī)院感染患者作為感染組,另選取同期在醫(yī)院進(jìn)行治療的50例骨科非感染患者作為非感染組,分析骨科醫(yī)院感染患者病原菌種類及兩組T淋巴細(xì)胞亞群變化情況和細(xì)胞因子變化情況。結(jié)果 50例骨科醫(yī)院感染患者共檢出病原菌49株,其中革蘭陰性菌28株占57.14%,以銅綠假單胞菌、大腸埃希菌、肺炎克雷伯菌為主;革蘭陽性菌20株占40.82%,以金黃色葡萄球菌、表皮葡萄球菌為主;真菌1株占2.04%。感染組T淋巴細(xì)胞亞群CD3~+(55.28±3.35)%、CD4~+(34.01±6.32)%、CD4~+/CD8~+(1.52±0.21)水平較非感染組CD3~+(60.21±2.03)%、CD4~+(40.18±7.05)%、CD4~+/CD8~+(1.74±0.25)均明顯降低(P0.05);感染組細(xì)胞因子IL-4(2.40±0.23)%、IL-6(3.11±0.35)%較非感染組(2.12±0.27)%、(2.64±0.30)%水平均明顯升高(P0.05);兩組CD8~+,IL-17,IFN-γ水平,差異均無統(tǒng)計(jì)學(xué)意義。結(jié)論骨科醫(yī)院感染患者T淋巴細(xì)胞亞群CD3~+和CD4~+水平,細(xì)胞因子IL-4、IL-6、IL-17和IFN-γ水平的監(jiān)測(cè),對(duì)患者術(shù)后感染情況的評(píng)估具有一定的參考價(jià)值。
[Abstract]:Objective to investigate the clinical value of T lymphocyte subsets and cytokines in patients with orthopaedic nosocomial infection. Methods from January 2013 to December 2015, 50 patients with orthopedic nosocomial infection were selected as infection group, and 50 patients with orthopedic nosocomial infection who were treated in hospital during the same period were selected as non-infection group. The changes of T lymphocyte subsets and cytokines in patients with orthopedic nosocomial infection were analyzed. Results 49 strains of pathogenic bacteria were detected in 50 patients with orthopedic nosocomial infection, of which 28 were Gram-negative bacteria (57.14), mainly Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae. Gram-positive bacteria accounted for 40.82%, mainly Staphylococcus aureus and Staphylococcus epidermidis, and 1 strain of fungi accounted for 2.04%. The levels of CD3~, CD4~, CD4~ / CD8~ in infected group were (55.28 鹵3.35)%, (34.01 鹵6.32)%, (1.52 鹵0.21)%, respectively, which were significantly higher than those in non-infected group (60.21 鹵2.03)%, (40.18 鹵7.05)%, respectively). CD4~ / CD8~ (1. 74 鹵0. 25) were significantly decreased (P0.05). The levels of cytokine IL-4 (2.40 鹵0.23)%, IL-6 (3.11 鹵0.35)% in infected group were significantly higher than those in non-infected group (2.12 鹵0.27)% and (2.64 鹵0.30)% (P0.05). There was no significant difference in the levels of CD8~ and IL-17,IFN- 緯 between the two groups. Conclusion Monitoring the levels of T lymphocyte subsets CD3~ and CD4~, cytokines IL-4,IL-6,IL-17 and IFN- 緯 in patients with orthopedic nosocomial infection has certain reference value for the evaluation of postoperative infection.
【作者單位】： 寧波市鎮(zhèn)海區(qū)人民醫(yī)院骨科;浙江大學(xué)醫(yī)學(xué)院附屬第二醫(yī)院骨科;
【基金】：浙江省自然科學(xué)基金資助項(xiàng)目(Y2110448)
【分類號(hào)】：R68

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