Lenke3型成人特發(fā)性脊柱側(cè)凸有限元模型的參數(shù)修正及有效性驗(yàn)證
發(fā)布時(shí)間：2018-12-19 18:35
【摘要】：背景:作者利用Mimics等有限元軟件成功建立了Lenke3型成人特發(fā)性脊柱有限元模型,但模型是否最大程度的符合個(gè)體化患者的真實(shí)情況,需要進(jìn)一步進(jìn)行模型修正及有效性驗(yàn)證。目的:利用有限元分析軟件對(duì)Lenke3型成人特發(fā)性脊柱有限元模型進(jìn)行修正及有效性驗(yàn)證。方法:根據(jù)Lenke3型成人特發(fā)性脊柱側(cè)凸模型的特點(diǎn),利用三因素三水平正交試驗(yàn)優(yōu)化有限元模型,使模型特點(diǎn)最大程度的接近真實(shí),通過(guò)模擬左右側(cè)屈實(shí)驗(yàn),分段加載選取T_1-T_4、T_5-T_8、L_6-S_1(骶椎腰化)節(jié)段分別模擬左右側(cè)屈、前屈后伸,左右旋轉(zhuǎn)活動(dòng)度與體外Busscher、Yamamoto實(shí)驗(yàn)進(jìn)行對(duì)比研究,多方位驗(yàn)證模型有效性。結(jié)果與結(jié)論:(1)根據(jù)正交實(shí)驗(yàn)計(jì)算各因素各水平的平均差異和極差R,最后計(jì)算出A1B2C3的最佳組合可使模擬實(shí)驗(yàn)結(jié)果最符合個(gè)體的真實(shí)情況,使得有限元模擬實(shí)驗(yàn)結(jié)果與患者臨床真實(shí)情況的差異最小。臨床側(cè)屈試驗(yàn)和參數(shù)修正前模型模擬的Cobb角度的變化差異值為54.44°,經(jīng)過(guò)參數(shù)修正后模型的差異值減小為2.11°。修正后模型各側(cè)凸Cobb角的最大差異為4.29°;(2)修正后的模型與仰臥左右側(cè)屈位X射線片對(duì)比,2組配對(duì)數(shù)據(jù)均服從正態(tài)分布,故利用配對(duì)t檢驗(yàn)進(jìn)行計(jì)算,左側(cè)屈時(shí),P=0.082,P0.05;右側(cè)屈時(shí),P=0.421,P0.05;仰臥位P=0.160,P0.05;(3)修正后的模型T_1-T_4節(jié)段各個(gè)方向的ROM:左屈3.25°,右屈3.32°,前屈2.52°,后伸2.89°,左側(cè)旋轉(zhuǎn)3.73°,右側(cè)旋轉(zhuǎn)3.76°,T5-T8節(jié)段各個(gè)方向的ROM:左屈1.39°,右屈1.43°,前屈1.35°,后伸1.34°,左旋2.09°,右旋2.11°;L_6/S_1節(jié)段各個(gè)方向的ROM:左屈5.17°,右屈5.19°,前屈8.92°,后伸7.35°,左旋1.41°,右旋1.42°,獲得的結(jié)果與Busscher及Yamamoto等的實(shí)驗(yàn)結(jié)果進(jìn)行比較,結(jié)果基本吻合;(4)結(jié)果提示,通過(guò)對(duì)初始模型進(jìn)行參數(shù)修正處理,使得模型與患者真實(shí)的材料屬性基本符合。修正后的模型具有較好的可靠性和有效性,為下一步模擬臨床手術(shù)操作提供了有效的數(shù)據(jù)平臺(tái)。
[Abstract]:Background: the author has successfully established the Lenke3 type adult idiopathic spinal column finite element model by using Mimics and other finite element software, but whether the model accords with the real situation of individual patients to the greatest extent, needs to be further revised and validated. Objective: to modify and validate the Lenke3 model of adult idiopathic spinal column by finite element analysis software. Methods: according to the characteristics of Lenke3 model of adult idiopathic scoliosis, the finite element model was optimized by using three factors and three levels of orthogonal experiments. Segmental loading and selecting T _ 1-T _ 4 and T _ 5-T _ 5 _ S _ 1 (sacral lumbar vertebrae) segment to simulate the flexion of left and right side, flexion and extension of anterior flexion, rotation activity of left and right and Busscher,Yamamoto experiment in vitro respectively, The validity of the model is verified in multiple directions. Results and conclusions: (1) based on the orthogonal experiment, the average differences and ranges of each factor level were calculated. Finally, the optimal combination of A1B2C3 was calculated to make the simulation results best accord with the real situation of individual. The difference between the finite element simulation results and the patient's clinical reality is minimized. The variation of Cobb angle was 54.44 擄in the model before clinical flexion test and parameter modification, and the difference value decreased to 2.11 擄after parameter modification. The maximum difference of Cobb angle of the modified model is 4.29 擄. (2) the modified model was compared with the supine lateral and right flexion X-ray films. The data of the two groups were normally distributed, so the paired t test was used to calculate, the left flexion, P0. 082, P0. 05, the right, P0. 421, P0. 05, and the right, P0. 421, P0. 05, respectively. The supine position was 0.160 (P0.05); (3) the ROM: of the modified T_1-T_4 segment was 3.25 擄left flexion, 3.32 擄right flexion, 2.52 擄forward flexion, 2.89 擄extension, 3.73 擄left rotation and 3.76 擄right rotation. ROM: in all directions of T5-T8 segment was 1.39 擄left flexion, 1.43 擄right flexion, 1.35 擄forward flexion, 1.34 擄extension, 2.09 擄left lateral flexion and 2.11 擄dextral flexion. The results of left flexion 5.17 擄, right flexion 5.19 擄, forward flexion 8.92 擄, extension 7.35 擄, left lateral 1.41 擄, right-hand 1.42 擄in all directions of L_6/S_1 segment were compared with those of Busscher and Yamamoto. The results were basically consistent. (4) the results suggest that the model is basically consistent with the patient's real material properties by modifying the parameters of the initial model. The modified model has good reliability and effectiveness, and provides an effective data platform for the next step to simulate the clinical operation.
【作者單位】： 內(nèi)蒙古醫(yī)科大學(xué)第二附屬醫(yī)院;重慶醫(yī)科大學(xué)附屬第一醫(yī)院骨科;內(nèi)蒙古醫(yī)科大學(xué)附屬醫(yī)院;
【基金】：內(nèi)蒙古自治區(qū)自然科學(xué)基金(2016MS08141)~~
【分類(lèi)號(hào)】：R682.3
，
本文編號(hào)：2387297
[Abstract]:Background: the author has successfully established the Lenke3 type adult idiopathic spinal column finite element model by using Mimics and other finite element software, but whether the model accords with the real situation of individual patients to the greatest extent, needs to be further revised and validated. Objective: to modify and validate the Lenke3 model of adult idiopathic spinal column by finite element analysis software. Methods: according to the characteristics of Lenke3 model of adult idiopathic scoliosis, the finite element model was optimized by using three factors and three levels of orthogonal experiments. Segmental loading and selecting T _ 1-T _ 4 and T _ 5-T _ 5 _ S _ 1 (sacral lumbar vertebrae) segment to simulate the flexion of left and right side, flexion and extension of anterior flexion, rotation activity of left and right and Busscher,Yamamoto experiment in vitro respectively, The validity of the model is verified in multiple directions. Results and conclusions: (1) based on the orthogonal experiment, the average differences and ranges of each factor level were calculated. Finally, the optimal combination of A1B2C3 was calculated to make the simulation results best accord with the real situation of individual. The difference between the finite element simulation results and the patient's clinical reality is minimized. The variation of Cobb angle was 54.44 擄in the model before clinical flexion test and parameter modification, and the difference value decreased to 2.11 擄after parameter modification. The maximum difference of Cobb angle of the modified model is 4.29 擄. (2) the modified model was compared with the supine lateral and right flexion X-ray films. The data of the two groups were normally distributed, so the paired t test was used to calculate, the left flexion, P0. 082, P0. 05, the right, P0. 421, P0. 05, and the right, P0. 421, P0. 05, respectively. The supine position was 0.160 (P0.05); (3) the ROM: of the modified T_1-T_4 segment was 3.25 擄left flexion, 3.32 擄right flexion, 2.52 擄forward flexion, 2.89 擄extension, 3.73 擄left rotation and 3.76 擄right rotation. ROM: in all directions of T5-T8 segment was 1.39 擄left flexion, 1.43 擄right flexion, 1.35 擄forward flexion, 1.34 擄extension, 2.09 擄left lateral flexion and 2.11 擄dextral flexion. The results of left flexion 5.17 擄, right flexion 5.19 擄, forward flexion 8.92 擄, extension 7.35 擄, left lateral 1.41 擄, right-hand 1.42 擄in all directions of L_6/S_1 segment were compared with those of Busscher and Yamamoto. The results were basically consistent. (4) the results suggest that the model is basically consistent with the patient's real material properties by modifying the parameters of the initial model. The modified model has good reliability and effectiveness, and provides an effective data platform for the next step to simulate the clinical operation.
【作者單位】： 內(nèi)蒙古醫(yī)科大學(xué)第二附屬醫(yī)院;重慶醫(yī)科大學(xué)附屬第一醫(yī)院骨科;內(nèi)蒙古醫(yī)科大學(xué)附屬醫(yī)院;
【基金】：內(nèi)蒙古自治區(qū)自然科學(xué)基金(2016MS08141)~~
【分類(lèi)號(hào)】：R682.3
，
本文編號(hào)：2387297
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