【摘要】：目的：觀察接骨藥丸對(duì)人工全膝關(guān)節(jié)置換術(shù)后假體周圍骨密度值的影響,探討整骨接骨藥丸治療假體無(wú)菌性松動(dòng)的作用,為接骨藥丸在預(yù)防和治療人工全膝關(guān)節(jié)置換術(shù)后假體無(wú)菌性松動(dòng)提供臨床依據(jù)。方法：本研究納入80例需行初次人工全膝關(guān)節(jié)置換患者,予以隨機(jī)分為接骨藥丸組和對(duì)照組；術(shù)后第2周接骨藥丸組予以接骨藥丸6g+鈣爾奇D 0.6g,對(duì)照組予以鈣爾奇D 0.6g,每天一次,3個(gè)月為一個(gè)療程,兩療程間間隔2周,共治療3個(gè)療程。3個(gè)療程結(jié)束后,使用XR-800全身骨密度測(cè)量?jī)x檢測(cè)膝關(guān)節(jié)假體周圍各區(qū)的骨密度值(BMD),采用酶聯(lián)免疫吸附法(ELISA)分別檢測(cè)ALP和TRAP含量。結(jié)果：1.接骨藥丸組與對(duì)照組在治療前BMD值均無(wú)顯著性差異(P0.05)；在接骨藥丸組與對(duì)照組比較,接骨藥丸組經(jīng)治療后假體周圍BMD值明顯高于對(duì)照組(P0.05).2.A LP含量接骨藥丸組與對(duì)照組在治療后均有明顯增加；但接骨藥丸組在治療后ALP含量高于對(duì)照組(P0.05)。3.TRAP含量接骨藥丸組與對(duì)照組在治療后均有降低；但接骨藥丸組在治療后TRAP含量顯著低于對(duì)照組(P0.05)。結(jié)論：1.接骨藥丸較對(duì)照組可明顯改善人工全膝關(guān)節(jié)假體周圍骨質(zhì),提高骨密度,促進(jìn)骨生成,抑制骨破壞,增強(qiáng)對(duì)假體的支撐作用。2.接骨藥丸具有服用方便、副作用少優(yōu)點(diǎn)。可作為人工全膝關(guān)節(jié)置換術(shù)后假體無(wú)菌性松動(dòng)預(yù)防用藥。
[Abstract]:Objective: to observe the effect of Jiegu pills on bone mineral density (BMD) of prosthesis after total knee arthroplasty, and to explore the effect of Jiegu pills on aseptic loosening of prosthesis. To provide clinical basis for the prevention and treatment of prosthetic aseptic loosening after total knee arthroplasty. Methods: 80 patients with primary total knee arthroplasty were randomly divided into two groups: group B and control group. At the second week after operation, the group of Jiegu pills was given 6g of calachylic D 0.6 g, and the control group was given 0.6 g of calcareous D, once a day, 3 months as a course of treatment, the interval between two courses of treatment was 2 weeks, a total of 3 courses of treatment were treated after the end of 3 courses of treatment. Bone mineral density (BMD) around the prosthesis of knee joint was measured by XR-800 whole body bone mineral density (BMD). The contents of ALP and TRAP were detected by enzyme-linked immunosorbent assay (ELISA). Results: 1. There was no significant difference in BMD between the two groups before treatment (P0.05). Compared with the control group, the BMD value around the prosthesis in the Jiegu pill group was significantly higher than that in the control group (P0.05). 2. The content of LP in the Jiegu pill group and the control group were significantly increased after treatment. However, the content of ALP in Jiegu pill group was higher than that in control group after treatment (P0.05). The 3.TRAP content in Jiegu pill group and control group were decreased after treatment, but the TRAP content in Jiegu pill group was significantly lower than that in control group after treatment (P0.05). Conclusion: 1. Compared with the control group, Jiegu pill can obviously improve the bone around artificial total knee prosthesis, increase bone density, promote bone formation, inhibit bone destruction, and enhance the supporting effect on prosthesis. 2. Jiegu pills have the advantages of convenient taking and less side effects. It can be used as prophylaxis of aseptic loosening of prosthesis after total knee arthroplasty.
【學(xué)位授予單位】：福建中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R687.4

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本文編號(hào)：2372647