【摘要】：目的：觀察接骨藥丸對人工全膝關(guān)節(jié)置換術(shù)后假體周圍骨密度值的影響,探討整骨接骨藥丸治療假體無菌性松動的作用,為接骨藥丸在預(yù)防和治療人工全膝關(guān)節(jié)置換術(shù)后假體無菌性松動提供臨床依據(jù)。方法：本研究納入80例需行初次人工全膝關(guān)節(jié)置換患者,予以隨機分為接骨藥丸組和對照組；術(shù)后第2周接骨藥丸組予以接骨藥丸6g+鈣爾奇D 0.6g,對照組予以鈣爾奇D 0.6g,每天一次,3個月為一個療程,兩療程間間隔2周,共治療3個療程。3個療程結(jié)束后,使用XR-800全身骨密度測量儀檢測膝關(guān)節(jié)假體周圍各區(qū)的骨密度值(BMD),采用酶聯(lián)免疫吸附法(ELISA)分別檢測ALP和TRAP含量。結(jié)果：1.接骨藥丸組與對照組在治療前BMD值均無顯著性差異(P0.05)；在接骨藥丸組與對照組比較,接骨藥丸組經(jīng)治療后假體周圍BMD值明顯高于對照組(P0.05).2.A LP含量接骨藥丸組與對照組在治療后均有明顯增加；但接骨藥丸組在治療后ALP含量高于對照組(P0.05)。3.TRAP含量接骨藥丸組與對照組在治療后均有降低；但接骨藥丸組在治療后TRAP含量顯著低于對照組(P0.05)。結(jié)論：1.接骨藥丸較對照組可明顯改善人工全膝關(guān)節(jié)假體周圍骨質(zhì),提高骨密度,促進骨生成,抑制骨破壞,增強對假體的支撐作用。2.接骨藥丸具有服用方便、副作用少優(yōu)點�？勺鳛槿斯とリP(guān)節(jié)置換術(shù)后假體無菌性松動預(yù)防用藥。
[Abstract]:Objective: to observe the effect of Jiegu pills on bone mineral density (BMD) of prosthesis after total knee arthroplasty, and to explore the effect of Jiegu pills on aseptic loosening of prosthesis. To provide clinical basis for the prevention and treatment of prosthetic aseptic loosening after total knee arthroplasty. Methods: 80 patients with primary total knee arthroplasty were randomly divided into two groups: group B and control group. At the second week after operation, the group of Jiegu pills was given 6g of calachylic D 0.6 g, and the control group was given 0.6 g of calcareous D, once a day, 3 months as a course of treatment, the interval between two courses of treatment was 2 weeks, a total of 3 courses of treatment were treated after the end of 3 courses of treatment. Bone mineral density (BMD) around the prosthesis of knee joint was measured by XR-800 whole body bone mineral density (BMD). The contents of ALP and TRAP were detected by enzyme-linked immunosorbent assay (ELISA). Results: 1. There was no significant difference in BMD between the two groups before treatment (P0.05). Compared with the control group, the BMD value around the prosthesis in the Jiegu pill group was significantly higher than that in the control group (P0.05). 2. The content of LP in the Jiegu pill group and the control group were significantly increased after treatment. However, the content of ALP in Jiegu pill group was higher than that in control group after treatment (P0.05). The 3.TRAP content in Jiegu pill group and control group were decreased after treatment, but the TRAP content in Jiegu pill group was significantly lower than that in control group after treatment (P0.05). Conclusion: 1. Compared with the control group, Jiegu pill can obviously improve the bone around artificial total knee prosthesis, increase bone density, promote bone formation, inhibit bone destruction, and enhance the supporting effect on prosthesis. 2. Jiegu pills have the advantages of convenient taking and less side effects. It can be used as prophylaxis of aseptic loosening of prosthesis after total knee arthroplasty.
【學位授予單位】：福建中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R687.4

【參考文獻】

相關(guān)期刊論文 前10條

1 湛川;于方;安久力;趙廣;袁宏謀;馮錫明;;骨疏康顆粒對髖關(guān)節(jié)置換術(shù)后人工假體周圍早期骨量的影響[J];山東醫(yī)藥;2007年18期

2 王建華;郭敏;鄭麗;王忠;;補骨脂素干預(yù)大鼠成骨細胞骨保護素/核因子κB受體激活因子配體mRNA的表達[J];中國組織工程研究與臨床康復(fù);2010年37期

3 譚維琴;楊士軍;崔建和;;人工假體置換后的無菌性松動[J];中國組織工程研究與臨床康復(fù);2011年43期

4 漆啟華;戴閩;程濤;范紅先;熊建衛(wèi);詹平;陳晟;;姜黃素抑制磨損顆粒誘導(dǎo)炎性介質(zhì)產(chǎn)生及作用機制[J];中國藥理學通報;2009年06期

5 王威;史紅;何永志;顧志敏;鄭紡;劉友剛;王超;胡利民;;中藥續(xù)斷含藥血清對成骨細胞增殖和骨基質(zhì)蛋白產(chǎn)生的影響[J];中國骨質(zhì)疏松雜志;2009年02期

6 蔡迅梓;嚴世貴;戴雪松;;全膝置換術(shù)后應(yīng)力遮擋致骨量丟失的研究進展[J];中華外科雜志;2006年20期

7 李立;聶偉志;;整骨接骨藥丸促進骨折愈合的臨床研究[J];中醫(yī)正骨;2008年07期

8 翟遠坤;武祥龍;潘亞磊;牛銀波;梅其炳;;補骨脂抗骨質(zhì)疏松研究概況[J];中醫(yī)雜志;2012年14期

9 王俊;朱旭日;張超;沈計榮;杜斌;;中藥淫羊藿苷干預(yù)人工關(guān)節(jié)磨損微粒誘導(dǎo)的骨溶解[J];中國組織工程研究;2014年17期

10 呂清華;楊少輝;許紅霞;;整骨接骨藥丸治療骨折的臨床療效觀察[J];中國中醫(yī)骨傷科雜志;2014年06期

相關(guān)碩士學位論文 前2條

1 倪遠鎮(zhèn);骨碎補總黃酮預(yù)防人工關(guān)節(jié)假體周圍骨溶解的實驗研究[D];福建中醫(yī)藥大學;2010年

2 鄒德寶;接骨藥丸對關(guān)節(jié)置換術(shù)后假體周圍骨密度影響的研究[D];福建中醫(yī)藥大學;2013年

，

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