【摘要】：目的探討骨代謝生化指標(biāo)與絕經(jīng)后骨質(zhì)疏松性腰椎骨折相關(guān)性,進而預(yù)測絕經(jīng)后骨質(zhì)疏松性合并腰椎骨折風(fēng)險。方法回顧性分析100例絕經(jīng)后骨質(zhì)疏松癥患者的臨床資料,包括絕經(jīng)后骨質(zhì)疏松癥腰椎無骨折患者50例和絕經(jīng)后骨質(zhì)疏松癥合并腰椎骨折患者50例,記錄并觀察髖部、腰椎骨密度、骨代謝生化標(biāo)志物Ⅰ型前膠原氨基端前肽(P1NP)、Ⅰ型膠原羧基端肽β特殊序列(β-CTX)、骨鈣素N端中分子(N-MID)、25-羥基維生素D[25-(OH)VitD]和血清Ca2+。結(jié)果P1NP、β-CTX和25-(OH)VitD的差異具有統(tǒng)計學(xué)意義(P0.05),絕經(jīng)后骨質(zhì)疏松性腰椎骨折與血清P1NP呈正相關(guān)(P0.05),25-(OH)VitD呈負(fù)相關(guān)(P0.05),β-CTX無相關(guān)性(P0.05)。結(jié)論骨代謝標(biāo)志物P1NP、25-(OH)VitD能夠很好地預(yù)測絕經(jīng)后骨質(zhì)疏松腰椎骨折風(fēng)險,骨密度預(yù)測骨質(zhì)疏松癥骨折風(fēng)險具有一定局限性。
[Abstract]:Objective to investigate the correlation between bone metabolism and postmenopausal osteoporotic lumbar vertebrae fracture, and to predict the risk of postmenopausal osteoporosis complicated with lumbar vertebra fracture. Methods the clinical data of 100 patients with postmenopausal osteoporosis were retrospectively analyzed, including 50 cases of postmenopausal osteoporosis without lumbar fracture and 50 cases of postmenopausal osteoporosis with lumbar vertebral fracture. Hip was recorded and observed. Lumbar vertebrae bone mineral density, bone metabolism biochemical marker type I procollagen amino terminal prepeptide (P1NP), type 鈪，

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