【摘要】：目的研究膽石癥疾病的發(fā)病率及其影響因素。方法以首次參加2006～2007年度健康體檢的101510例開(kāi)灤在職及退休職工作為研究對(duì)象開(kāi)展隨訪調(diào)查,觀察膽石癥的發(fā)病情況。對(duì)研究對(duì)象進(jìn)行統(tǒng)一問(wèn)卷調(diào)查、血液生化和腹部超聲檢查。最終納入統(tǒng)計(jì)分析的有82341例。用Kaplan-Meier法計(jì)算膽石癥的發(fā)病率,并用log-rank檢驗(yàn)比較不同性別、年齡人群膽石癥發(fā)病率的差異。采用Cox比例風(fēng)險(xiǎn)模型分析影響膽石癥的因素。結(jié)果1平均隨訪5.52±1.40年,在82341例研究對(duì)象中,隨訪期間腹部超聲檢查共檢出新發(fā)膽石癥1846例,其膽石癥累積發(fā)病率為2.2%。其中男性1434例,女性412例,其膽石癥累積發(fā)病率分別為2.2%、2.3%。2采用多變量Cox比例風(fēng)險(xiǎn)回歸模型分析膽石癥發(fā)病影響因素,結(jié)果顯示與膽石癥發(fā)病相關(guān)的危險(xiǎn)因素有年齡(40-60歲比40歲,HR=1.95[95%CI 1.63～2.33],≥60歲比40歲,HR=3.34[95%CI 2.75～4.06])、BMI(24-28kg/m2比24kg/m2,HR=1.33[95%CI1.19～1.49],≥28kg/m2比24kg/m2,HR=1.49[95%CI 1.30～1.71])、糖尿病(是比理想空腹血糖,HR=1.17[95%CI 1.01～1.36])、hs CRP(0.80-2.10mg/L比0.30mg/L,HR=1.22[95%CI 1.06～1.42],≥2.10mg/L比0.30mg/L,HR=1.48[95%CI 1.28～1.70]),保護(hù)因素有飲酒(是比否,HR=0.87[95%CI 0.77～0.99])。結(jié)論膽石癥的發(fā)病率均隨著年齡、血壓、BMI、空腹血糖的增長(zhǎng)而增高。增齡、高BMI、糖尿病、高h(yuǎn)s CRP屬于膽石癥發(fā)病的相關(guān)危險(xiǎn)性因素,適量飲酒屬于膽石癥發(fā)病的相關(guān)保護(hù)性因素。
[Abstract]:Objective to study the incidence of cholelithiasis and its influencing factors. Methods 101510 active and retired workers of Kailuan who first participated in the physical examination in 2006 and 2007 were followed up and the incidence of cholelithiasis was observed. The subjects were investigated by uniform questionnaire, blood biochemistry and abdominal ultrasound. Finally, 82341 cases were included in the statistical analysis. Kaplan-Meier method was used to calculate the incidence of cholelithiasis and log-rank test was used to compare the incidence of cholelithiasis among different genders and age groups. Cox proportional risk model was used to analyze the factors affecting cholelithiasis. Results (1) the mean follow-up was 5.52 鹵1.40 years. During the follow-up period, 1846 cases of new cholelithiasis were detected by abdominal ultrasonography, and the cumulative incidence of cholelithiasis was 2.2%. There were 1434 males and 412 females. The cumulative incidence of cholelithiasis was 2.2 and 2.3 respectively. Multivariate Cox proportional risk regression model was used to analyze the influencing factors of cholelithiasis. 緇撴灉鏄劇ず涓庤儐鐭崇棁鍙戠梾鐩稿叧鐨勫嵄闄╁洜绱犳湁騫撮緞(40-60宀佹瘮40宀，

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