肉芽腫性小葉性乳腺炎106例臨床病理特征及病因分析
發(fā)布時間：2018-09-09 11:43
【摘要】：目的探討肉芽腫性小葉性乳腺炎(granulomatous lobular mastitis,GLM)的臨床病理學(xué)特征,并分析其與非結(jié)核分枝桿菌(nontuberculous mycobacteria,NTM)感染的相關(guān)性。方法對106例已經(jīng)確診的GLM重新閱片,并行金胺O、PASM、PAS特殊染色及熒光定量PCR檢測。結(jié)果106例GLM均為女性,平均年齡33歲,有生育史及哺乳史104例,97例距末次妊娠3年發(fā)病,平均病程3個月。鏡下組織學(xué)特征以乳腺終末導(dǎo)管小葉單位為中心的慢性化膿性肉芽腫性炎癥。熒光定量PCR檢測結(jié)核/NTM均陰性,PASM、PAS特殊染色未查見真菌,金胺O特殊染色1分15例、2分3例,金胺O染色陰性88例,陽性率為16.98%。18例金胺O染色陽性患者隨訪發(fā)現(xiàn)伴竇道形成5例,手術(shù)切口愈合差者2例,在1年內(nèi)復(fù)發(fā)5例;88例金胺O染色陰性患者伴竇道形成14例,手術(shù)切口愈合差者5例,在3個月內(nèi)復(fù)發(fā)5例。結(jié)論GLM是少見的良性炎癥性乳腺疾病,NTM感染可能是GLM的病因之一,將金胺O、PASM、PAS特殊染色及熒光定量PCR聯(lián)合檢測可作為GLM的常規(guī)檢查,為治療GLM提供病理學(xué)依據(jù)。
[Abstract]:Objective to investigate the clinicopathological features of granulomatous lobular mastitis (granulomatous lobular mastitis,GLM) and its correlation with non-tuberculous Mycobacterium tuberculosis (nontuberculous mycobacteria,NTM) infection. Methods 106 cases of confirmed GLM were examined by special staining of Osmon pas and fluorescence quantitative PCR. Results all the 106 cases of GLM were female with an average age of 33 years. There were 97 cases with history of birth and lactation. The mean course of disease was 3 months after the last trimester of pregnancy. Histologic features of chronic suppurative granulomatous inflammation centered on the terminal ductal lobules of the mammary gland. No fungi were detected by fluorescence quantitative PCR in the pASMMA-PAS staining of tuberculous / NTM negative, there were 15 cases with gold amine O special staining, 3 cases with gold amine O staining, 88 cases with negative gold amine O staining. The positive rate was 16.980.18 cases of positive patients with positive gold amine O staining found 5 cases of sinus formation. There were 2 cases of poor healing of surgical incision, 5 cases of recurrence within one year, 14 cases of negative staining of gold amine O with sinus formation, 5 cases of poor healing of surgical incision, 5 cases of recurrence within 3 months. Conclusion GLM infection may be one of the etiology of GLM, which is a rare benign inflammatory mammary gland disease. The combination of Osmon pas special staining and fluorescence quantitative PCR can be used as the routine examination of GLM and provide pathological basis for the treatment of GLM.
【作者單位】： 福州市第八醫(yī)院病理科;福建省婦幼保健院病理科;解放軍福州總醫(yī)院病理科;
【基金】：2016年度福建省科技廳引導(dǎo)性項目(2016D004) 福州市科技局社會發(fā)展項目(2015-S-148)
【分類號】：R655.8
，
本文編號：2232273
[Abstract]:Objective to investigate the clinicopathological features of granulomatous lobular mastitis (granulomatous lobular mastitis,GLM) and its correlation with non-tuberculous Mycobacterium tuberculosis (nontuberculous mycobacteria,NTM) infection. Methods 106 cases of confirmed GLM were examined by special staining of Osmon pas and fluorescence quantitative PCR. Results all the 106 cases of GLM were female with an average age of 33 years. There were 97 cases with history of birth and lactation. The mean course of disease was 3 months after the last trimester of pregnancy. Histologic features of chronic suppurative granulomatous inflammation centered on the terminal ductal lobules of the mammary gland. No fungi were detected by fluorescence quantitative PCR in the pASMMA-PAS staining of tuberculous / NTM negative, there were 15 cases with gold amine O special staining, 3 cases with gold amine O staining, 88 cases with negative gold amine O staining. The positive rate was 16.980.18 cases of positive patients with positive gold amine O staining found 5 cases of sinus formation. There were 2 cases of poor healing of surgical incision, 5 cases of recurrence within one year, 14 cases of negative staining of gold amine O with sinus formation, 5 cases of poor healing of surgical incision, 5 cases of recurrence within 3 months. Conclusion GLM infection may be one of the etiology of GLM, which is a rare benign inflammatory mammary gland disease. The combination of Osmon pas special staining and fluorescence quantitative PCR can be used as the routine examination of GLM and provide pathological basis for the treatment of GLM.
【作者單位】： 福州市第八醫(yī)院病理科;福建省婦幼保健院病理科;解放軍福州總醫(yī)院病理科;
【基金】：2016年度福建省科技廳引導(dǎo)性項目(2016D004) 福州市科技局社會發(fā)展項目(2015-S-148)
【分類號】：R655.8
，
本文編號：2232273
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