初次全髖置換中羥基磷灰石涂層是否優(yōu)于多孔涂層的meta分析
發(fā)布時(shí)間：2018-09-08 08:34
【摘要】：全髖置換中,使用多孔涂層還是羥基磷灰石涂層的效果哪一個(gè)更好一直存在爭(zhēng)議,部分研究表明兩者并無顯著性差異,但是也有一些研究顯示羥基磷灰石涂層優(yōu)于多孔涂層。我們通過檢索Pubmed、Medline、EMBASE和Cochrane圖書館等數(shù)據(jù)庫(kù),搜索詞是(HA OR hydroxyapatite) AND ((total hip arthroplasty) OR (total hip replacement)) AND (RCT*OR randomiz*OR control*OR compar*OR trial*).我們主要評(píng)價(jià)指標(biāo)是Harris評(píng)分和生存率,其余評(píng)價(jià)指標(biāo)是骨溶解、透光線發(fā)生率和聚乙烯磨損率等。我們最終納入12篇RCT和9篇對(duì)照試驗(yàn)。我們研究結(jié)果表明羥基磷灰石涂層能夠提高術(shù)后Harris評(píng)分,減少大腿疼痛發(fā)生率、減少骨溶解發(fā)生率,但是在生存率、聚乙烯磨損率上并無顯著性差異,亞組分析結(jié)果顯示,生存率跟隨訪時(shí)間相關(guān),如果給予足夠的隨訪時(shí)間,羥基磷灰石涂層應(yīng)該優(yōu)于多孔涂層。羥基磷灰石的特性和假體設(shè)計(jì)能夠影響大腿疼痛發(fā)生率、骨溶解和聚乙烯磨損等。
[Abstract]:In total hip arthroplasty, the effect of using porous coating or hydroxyapatite coating has been controversial. Some studies show that there is no significant difference between them, but some studies show that hydroxyapatite coating is better than porous coating. We search for databases such as Pubmed,Medline,EMBASE and Cochrane libraries, and the search term is (HA OR hydroxyapatite) AND (total hip arthroplasty) OR (total hip replacement) AND (RCT*OR randomiz*OR control*OR compar*OR trial*. Our main indicators were Harris score and survival rate, and the others were osteolysis, light transmission line rate and polyethylene wear rate. We eventually included 12 RCT and 9 controlled trials. Our results showed that hydroxyapatite coating could improve postoperative Harris score, reduce thigh pain and osteolysis, but there was no significant difference in survival rate, polyethylene wear rate, and subgroup analysis. Survival rate is related to follow-up time and hydroxyapatite coating should be superior to porous coating if sufficient follow-up time is given. Hydroxyapatite properties and prosthesis design can affect thigh pain, osteolysis and polyethylene wear.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R687.4
本文編號(hào)：2229996
[Abstract]:In total hip arthroplasty, the effect of using porous coating or hydroxyapatite coating has been controversial. Some studies show that there is no significant difference between them, but some studies show that hydroxyapatite coating is better than porous coating. We search for databases such as Pubmed,Medline,EMBASE and Cochrane libraries, and the search term is (HA OR hydroxyapatite) AND (total hip arthroplasty) OR (total hip replacement) AND (RCT*OR randomiz*OR control*OR compar*OR trial*. Our main indicators were Harris score and survival rate, and the others were osteolysis, light transmission line rate and polyethylene wear rate. We eventually included 12 RCT and 9 controlled trials. Our results showed that hydroxyapatite coating could improve postoperative Harris score, reduce thigh pain and osteolysis, but there was no significant difference in survival rate, polyethylene wear rate, and subgroup analysis. Survival rate is related to follow-up time and hydroxyapatite coating should be superior to porous coating if sufficient follow-up time is given. Hydroxyapatite properties and prosthesis design can affect thigh pain, osteolysis and polyethylene wear.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R687.4
【參考文獻(xiàn)】
相關(guān)期刊論文 前2條
1 肖秀峰,劉榕芳,鄭煬曾;羥基磷灰石/氧化鋯復(fù)合涂層熱穩(wěn)定性和結(jié)合強(qiáng)度的研究[J];無機(jī)化學(xué)學(xué)報(bào);2005年07期
2 嚴(yán)尚誠(chéng),袁毓,徐本明,曹永平;羥基磷灰石涂層人工股骨柄的臨床應(yīng)用[J];中華骨科雜志;1997年03期
，本文編號(hào)：2229996
本文鏈接：http://sikaile.net/yixuelunwen/waikelunwen/2229996.html
最近更新
教材專著
