【摘要】：目的恒溫持續(xù)循環(huán)熱灌注治療已廣泛用于胸、腹腔臟器腫瘤治療,取得較滿意效果。本研究乳腺癌改良根治術(shù)后應(yīng)用恒溫持續(xù)循環(huán)熱灌注治療的可行性。方法選取2014-02-01-2016-02-28河南大學(xué)第一附屬醫(yī)院(56例)和河南大學(xué)淮河醫(yī)院(23例)行乳腺癌改良根治術(shù)的79例患者作為研究對象。采用BR-TRG-Ⅱ體腔熱灌注治療系統(tǒng),配制無菌蒸餾水1 500mL,恒溫43.5℃,共進行156次恒溫持續(xù)循環(huán)熱灌注治療,觀察治療過程中患者的雙側(cè)腋溫、雙側(cè)掌心溫度、局部皮膚顏色、傷口局部滲液及漏液、傷口愈合情況和生命體征變化等,并進行統(tǒng)計學(xué)分析。結(jié)果治療前后患側(cè)腋窩溫度分別為(36.8±0.2)℃和(37.5±0.2)℃,健側(cè)腋窩溫度分別為(36.9±0.2)℃和(36.9±0.2)℃,患側(cè)與健側(cè)相比差異有統(tǒng)計學(xué)意義,P0.05。治療前后患側(cè)掌心溫度分別為(36.8±0.2)℃和(37.1±0.2)℃,健側(cè)掌心溫度分別為(36.7±0.1)℃和(36.8±0.2)℃,雙側(cè)掌心溫度變化差異無統(tǒng)計學(xué)意義,P0.05。生命體征在治療前、中、后差異均無統(tǒng)計學(xué)意義,P0.05。熱灌注治療后24h創(chuàng)腔引流量100mL,48h引流量40mL,72h引流量30mL,引流管均在1周內(nèi)拔出。所有傷口均甲級愈合。29例皮膚厚度3mm的患者,隨皮膚溫度升高出現(xiàn)局部皮膚發(fā)紅,但無皮膚燙傷和壞死患者。14次出現(xiàn)傷口滲液,僅包扎敷料滲濕,無發(fā)現(xiàn)漏液及水腫。結(jié)論乳腺癌改良根治術(shù)后應(yīng)用恒溫持續(xù)循環(huán)熱灌注治療,對非治療部位影響較小,不影響術(shù)后傷口愈合和生命體征,是一種安全可行的治療方法,值得臨床推廣應(yīng)用。
[Abstract]:Objective Thermotherapy with constant temperature and continuous circulation has been widely used in the treatment of thoracic and abdominal organ tumors, and satisfactory results have been obtained. To study the feasibility of continuous circulatory hyperthermic perfusion after modified radical mastectomy for breast cancer. Methods Seventy-nine patients undergoing modified radical mastectomy in the first affiliated Hospital of Henan University (56 cases) and Huaihe Hospital of Henan University (23 cases) were selected as subjects. BR-TRG- 鈪，

本文編號：2223190