【摘要】：目的:觀(guān)察顱底骨折合并顱內(nèi)感染患者中血清降鈣素原(PCT)的水平及其變化,探討血清PCT值在顱底骨折合并顱內(nèi)感染患者早期診斷中的作用。方法:運(yùn)用酶聯(lián)熒光分析法(ELFA法)測(cè)定30例顱底骨折住院期間經(jīng)保守治療的患者。出院時(shí)根據(jù)顱內(nèi)感染的診斷結(jié)果,將其分為感染組(n=15)和非感染組(n=15)。設(shè)定傷后第1天為(T1)、第2天為(T2)、第3天為(T3)、感染組確診顱內(nèi)感染時(shí)間與未感染組相同時(shí)間為(T4),出院時(shí)間為(T5),五個(gè)時(shí)間段取血樣測(cè)定的血液常規(guī)檢測(cè)、血清PCT值。對(duì)比分析不同時(shí)間點(diǎn)的血清PCT濃度、血液各項(xiàng)檢測(cè)指標(biāo)。待顱底骨折患者耳鼻無(wú)漏液時(shí),行腰椎穿刺術(shù)取腦脊液檢測(cè)腦脊液常規(guī)、生化,腦脊液PCT值及行腦脊液細(xì)菌培養(yǎng)。探討血清PCT值在顱底骨折合并顱內(nèi)感染患者中的早期診斷的作用。結(jié)果:1.顱底骨折患者中,T1感染組血清PCT值大于對(duì)照組,差異有顯著性;未感染組與對(duì)照組血清PCT值無(wú)統(tǒng)計(jì)學(xué)意義。T2、T3、T4感染組、未感染組血清PCT值均大于對(duì)照組,差異有顯著性。T2、T3、T4感染組血清PCT值均大于未感染組,差異有顯著性;T5三組血清PCT值無(wú)統(tǒng)計(jì)學(xué)意義。2.T4感染組血液WBC值、NEU%、體溫℃均大于未感染組,差異有顯著性。3.以血清PCT≥0.185ng/m L為陽(yáng)性閾值,對(duì)顱底骨折合并顱內(nèi)感染的診斷靈敏度為93.3%,特異度86.7%。結(jié)論:顱底骨折可引起血清PCT值升高;顱底骨折合并顱內(nèi)感染患者中,動(dòng)態(tài)觀(guān)察血清PCT可以早期發(fā)現(xiàn)顱內(nèi)感染,血清PCT可以作為早期診斷的參考指標(biāo)。
[Abstract]:Objective: to observe the level and change of serum procalcitonin (PCT) in patients with skull base fracture complicated with intracranial infection, and to explore the role of serum PCT in early diagnosis of skull base fracture with intracranial infection. Methods: 30 patients with skull base fracture were treated conservatively by enzyme linked fluorescence assay (ELFA). According to the diagnostic results of intracranial infection, the patients were divided into two groups: the infected group (nong15) and the non-infective group (nong15). The first day, the second day and the third day after injury were set as T1, T2 and T3, respectively. The time of confirmed intracranial infection in the infected group was the same as that in the non-infected group (T4), and the discharge time was (T5). The serum PCT concentration and blood indexes were compared and analyzed at different time points. When there was no fluid leakage in the ear and nose of the patients with skull base fracture, cerebrospinal fluid (CSF) routine, biochemistry, cerebrospinal fluid (PCT) value and cerebrospinal fluid (CSF) bacterial culture were detected by lumbar puncture. To investigate the value of serum PCT in the early diagnosis of skull base fracture with intracranial infection. The result is 1: 1. The serum PCT value of T1-infected group was higher than that of control group, and the serum PCT value of non-infected group and control group had no statistical significance. The serum PCT value of non-infected group was higher than that of control group, and that of non-infected group was higher than that of control group. There was significant difference in serum PCT value of T2T3T4 infection group than that of uninfected group. There was no significant difference in serum PCT value of T5 group. 2.The blood WBC value of T4 infection group was higher than that of non-infected group, and the temperature at temperature was higher than that of uninfected group, and the difference was significant. Using serum PCT 鈮，

本文編號(hào)：2212024