發(fā)布時(shí)間：2018-08-09 18:52

【摘要】：背景:脊髓損傷后脊髓神經(jīng)功能因缺血缺氧出現(xiàn)的繼發(fā)性細(xì)胞凋亡是造成脊髓功能難以恢復(fù)的主要因素,高原地區(qū)因大氣壓力降低會(huì)使患者處于低氧的環(huán)境中,對(duì)脊髓損傷恢復(fù)非常不利,而高壓氧能提升組織中氧含量,可能促進(jìn)患者術(shù)后功能的改善。目的:觀察高壓氧治療高原地區(qū)創(chuàng)傷性脊髓損傷的效果。方法:研究為正在中國(guó)青海大學(xué)附屬醫(yī)院脊柱外科進(jìn)行的一項(xiàng)前瞻性開(kāi)放性隨機(jī)對(duì)照臨床試驗(yàn)。164例符合標(biāo)準(zhǔn)的高原地區(qū)創(chuàng)傷性不完全脊髓損傷患者,隨機(jī)分為對(duì)照組和高壓氧組,各82例。對(duì)照組采取椎弓根系統(tǒng)內(nèi)固定及椎板切除減壓等常規(guī)外科方法治療,高壓氧組在此基礎(chǔ)上,采取0.2 MPa高壓氧治療,1次/d,10次為1個(gè)療程,2個(gè)療程中休息5-7 d,持續(xù)4個(gè)療程。主要結(jié)局指標(biāo)為治療結(jié)束后以改良Barthel指數(shù)比較治療前的變化值,其可體現(xiàn)患者日常生活活動(dòng)能力的變化。次要結(jié)局指標(biāo)為以美國(guó)脊髓損傷協(xié)會(huì)分級(jí)、感覺(jué)評(píng)分和運(yùn)動(dòng)評(píng)分評(píng)價(jià)治療前和治療結(jié)束后相關(guān)功能的恢復(fù)情況。研究方案已于2012年4月經(jīng)中國(guó)青海大學(xué)附屬醫(yī)院倫理委員會(huì)批準(zhǔn),批準(zhǔn)號(hào)QHC011K。試驗(yàn)取得患者親屬或法定代理人的書(shū)面知情同意。結(jié)果與結(jié)論:目前已完成的部分試驗(yàn)結(jié)果顯示,治療4個(gè)療程(55-61 d)后高壓氧組患者改良巴氏指數(shù)、美國(guó)脊髓損傷協(xié)會(huì)觸覺(jué)、痛覺(jué)和運(yùn)動(dòng)評(píng)分均高于對(duì)照組,高壓氧組患者和對(duì)照組患者美國(guó)脊髓損傷協(xié)會(huì)分級(jí)情況差異較大,且高壓氧組患者D級(jí)和E級(jí)所占的比例高于對(duì)照組。試驗(yàn)旨在說(shuō)明高壓氧治療高原地區(qū)創(chuàng)傷性不完全脊髓損傷患者的有效性,為高原地區(qū)創(chuàng)傷性不完全脊髓損傷患者的高壓氧治療提供臨床依據(jù)。
[Abstract]:Background: secondary apoptosis of spinal cord nerve function due to ischemia and hypoxia after spinal cord injury is the main factor causing spinal cord function to recover. Hyperbaric oxygen can increase the content of oxygen in the tissue and may promote the improvement of postoperative function. Objective: to observe the effect of hyperbaric oxygen on traumatic spinal cord injury at high altitude. Methods: a prospective randomized controlled clinical trial of 164 patients with traumatic incomplete spinal cord injury at high altitude was conducted in the Department of Spinal surgery, affiliated Hospital of Qinghai University, China. They were randomly divided into control group and hyperbaric oxygen group with 82 cases each. The control group was treated with conventional surgical methods such as pedicle system fixation and laminectomy and decompression. On this basis, the hyperbaric oxygen group was treated with 0.2 MPa hyperbaric oxygen for 10 times as a course of treatment. The main outcome index was the modified Barthel index after treatment, which could reflect the changes of the patients' activities of daily life. The secondary outcome index was the American Spinal Cord injury Association (Asci) classification, sensory score and motor score to evaluate the recovery of related functions before and after treatment. The research program was approved by the Ethics Committee of Qinghai University affiliated Hospital in April, 2012, and approved No. QHC011K. The trial obtained the written informed consent of the patient's relative or legal representative. Results and conclusion: the results of some trials that have been completed at present show that the modified pasteurization index, tactile, pain and motor scores of patients in the hyperbaric oxygen group after 4 courses of treatment (55-61 days) are higher than those in the control group. The scores of American Spinal Cord injury Association in hyperbaric oxygen group and control group were significantly different, and the proportion of D and E grade in hyperbaric oxygen group was higher than that in control group. The purpose of this study was to demonstrate the efficacy of hyperbaric oxygen in the treatment of traumatic incomplete spinal cord injury at high altitude, and to provide a clinical basis for hyperbaric oxygen therapy in patients with traumatic incomplete spinal cord injury at high altitude.
【作者單位】： 青海大學(xué)附屬醫(yī)院脊柱外科;
【基金】：青海省衛(wèi)生和計(jì)劃生育委員會(huì)科研項(xiàng)目~~
【分類號(hào)】：R651.2

【參考文獻(xiàn)】

相關(guān)期刊論文 前8條

1 劉雪華;李茁;楊晶;梁芳;王泳;高春錦;;高壓氧治療對(duì)急性脊髓損傷大鼠內(nèi)質(zhì)網(wǎng)應(yīng)激凋亡的影響[J];中華航海醫(yī)學(xué)與高氣壓醫(yī)學(xué)雜志;2016年05期

2 譚杰文;胡輝軍;張芳;劉河軍;李茁;;磁共振及神經(jīng)電生理在高壓氧治療急性脊髓損傷療效評(píng)估中的應(yīng)用[J];中華航海醫(yī)學(xué)與高氣壓醫(yī)學(xué)雜志;2016年03期

3 李洋洋;石路;吳楠寧;劉俊松;張延猛;張明月;吳巖印;牟杰;劉洪濤;;高壓氧預(yù)處理對(duì)急性高海拔暴露體力負(fù)荷人體應(yīng)激反應(yīng)的作用[J];中華勞動(dòng)衛(wèi)生職業(yè)病雜志;2015年10期

4 馬俊;官眾;許勇;;高壓氧綜合治療高原地區(qū)急性創(chuàng)傷性脊髓損傷研究[J];高原醫(yī)學(xué)雜志;2015年03期

5 盧愛(ài)蘭;張夏軍;許美飛;;高壓氧對(duì)脊髓損傷肌張力控制的隊(duì)列研究[J];中國(guó)骨傷;2012年09期

6 王鋼,劉世清;高壓氧對(duì)鼠損傷脊髓內(nèi)神經(jīng)生長(zhǎng)相關(guān)蛋白表達(dá)的影響[J];中華物理醫(yī)學(xué)與康復(fù)雜志;2004年12期

7 李建軍,周紅俊,洪毅,季京平,劉根林,粟紹強(qiáng),趙超男,董云英,方玉美,譚鵬,周天健,張愛(ài)民,鄭櫻,北京市2002年脊髓損傷流行病學(xué)調(diào)查小組;2002年北京市脊髓損傷發(fā)病率調(diào)查[J];中國(guó)康復(fù)理論與實(shí)踐;2004年07期

8 胡光宇,湯華豐,唐林安;上海市松江縣脊柱脊髓損傷流行病學(xué)調(diào)查[J];中國(guó)脊柱脊髓雜志;1992年04期

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