發(fā)布時間：2018-08-02 16:58

【摘要】：目的探討開放性創(chuàng)傷手術(shù)切口感染患者血清炎性因子水平變化分析,為臨床診斷以及對相關(guān)實(shí)驗(yàn)室檢查指標(biāo)選擇提供依據(jù)。方法選取2012年9月-2014年3月因腹部創(chuàng)傷發(fā)生感染的住院患者90例為感染組,同期行甲狀腺切除術(shù)的未感染患者80例為非感染組,同期健康體檢者80名為對照組,對感染和非感染組患者的臨床資料進(jìn)行調(diào)查,包括患者年齡、手術(shù)時間、手術(shù)后傷口感染的程度、術(shù)后是否出現(xiàn)傷口周圍組織壞死,對各組中性粒細(xì)胞絕對值(ANC)、多形核粒細(xì)胞CD64(PMNCD64)、血清可溶性CD86(CD86)和親環(huán)素A(CyPA)水平及血清C-反應(yīng)蛋白(CRP)、白細(xì)胞介素-6(IL-6)、腫瘤壞死因子-α(TNF-α)水平變化進(jìn)行比較。結(jié)果各組ANC水平中感染組患者體內(nèi)的ANC水平要明顯高于非感染組和對照組,差異有統(tǒng)計學(xué)意義(P0.05);對于PMNCD64的水平顯示,感染組患者明顯高于其他兩組,差異有統(tǒng)計學(xué)意義(P0.05);對于sCD86的水平,其感染組患者水平要明顯高于對照組(P0.05),對照組和非感染組兩組之間比較,差異無統(tǒng)計學(xué)意義;CyPA水平比較,感染組和對照組之間差異有統(tǒng)計學(xué)意義(P0.05),其他兩組之間差異無統(tǒng)計學(xué)意義,同時感染組和非感染組之間差異無統(tǒng)計學(xué)意義;ANC與PMNCD64存在正相關(guān)性(P0.01);感染組患者的CRP、TNF-α、IL-6等炎性因子陽性率分別為97.8%、92.2%、95.6%,顯著高于對照組患者的3.75%、2.5%、3.75%,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論開放性創(chuàng)傷手術(shù)感染患者血清相關(guān)炎性因子會顯著升高,因此,對開放性創(chuàng)傷手術(shù)切口感染患者進(jìn)行相關(guān)炎性指標(biāo)的監(jiān)測有重要的意義。
[Abstract]:Objective to investigate the changes of serum inflammatory factors in patients with open wound infection, and to provide evidence for clinical diagnosis and the selection of laboratory indicators. Methods from September 2012 to March 2014, 90 inpatients with abdominal trauma were selected as infected group, 80 uninfected patients undergoing thyroidectomy and 80 healthy persons as control group. The clinical data of infected and non-infected patients were investigated, including age, duration of operation, degree of wound infection after operation, postoperative necrosis of tissue around the wound. The absolute value of neutrophil (ANC), polymorphonuclear CD64 (PMNCD64), serum soluble CD86 (CD86) and cyclophile A (CyPA), serum C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor- 偽 (TNF- 偽) were compared. Results the level of ANC in infected group was significantly higher than that in non-infection group and control group (P0.05). The level of PMNCD64 in infected group was significantly higher than that in other two groups (P0.05). The difference was statistically significant (P0.05); for the level of sCD86, the level of patients in the infected group was significantly higher than that in the control group (P0.05), but there was no significant difference between the two groups in the control group and the non-infected group. The difference between the infection group and the control group was statistically significant (P0.05), but there was no significant difference between the other two groups. There was no significant difference between the infection group and the non-infection group (P0.01), and the positive rate of inflammatory factors such as CRP- TNF- 偽 IL-6 in the infected group was 97.8% and 92.22%, respectively, which was significantly higher than that in the control group (3.75%), the difference was statistically significant (P0.05). Conclusion the serum levels of inflammatory cytokines in patients with open wound surgery infection are significantly increased, so it is of great significance to monitor the related inflammatory indexes in patients with open wound surgery infection.
【作者單位】： �？谑腥嗣襻t(yī)院傷口造口中心;
【基金】：海南省衛(wèi)生廳科研基金資助項(xiàng)目(瓊衛(wèi)2014-21)
【分類號】：R619.3

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