【摘要】：目的探討影響脊柱結(jié)核術(shù)后施行超短程化療方案的因素。方法回顧性分析2004年1月-2013年12月在寧夏醫(yī)科大學(xué)總醫(yī)院脊柱骨科行手術(shù)治療的211例脊柱結(jié)核患者。其中術(shù)后施行超短程化療方案的患者120例,男59例、女61例,年齡37.91±16.71歲;非超短程化療患者91例,男47例、女44例,年齡43.67±16.56歲。收集兩組患者術(shù)前、術(shù)中的臨床資料,包括初治或復(fù)治、年齡、術(shù)前是否合并其他疾病、是否合并其他部位活動(dòng)性結(jié)核、是否貧血、病變累及節(jié)段、是否合并膿腫、手術(shù)分期、植骨材料、病灶徹底清除情況、植骨方式、耐藥情況等12個(gè)方面。應(yīng)用單因素Logistic回歸分析,篩選出變量,再將其中有統(tǒng)計(jì)學(xué)意義的變量進(jìn)行多因素Logistic回歸分析,推測(cè)可能影響脊柱結(jié)核術(shù)后施行超短程化療方案的因素。結(jié)果超短程化療組120例隨訪(fǎng)時(shí)間38~154個(gè)月,平均90.11±30.81個(gè)月,化療療程3~6個(gè)月,平均4.65±0.98個(gè)月。非超短程化療組91例隨訪(fǎng)時(shí)間45~153個(gè)月,平均89.73±28.08個(gè)月,化療療程6.5~34個(gè)月,平均11.32±5.30個(gè)月。單因素和多因素Logistic回歸分析結(jié)果示:病灶徹底清除、植骨方式、累及節(jié)段等3個(gè)因素與超短程化療方案有顯著相關(guān)性(P0.05)。結(jié)論病灶徹底清除、支撐植骨是施行超短程化療方案的有利因素;病變累及多節(jié)段是施行超短程化療方案的不利因素。
[Abstract]:Objective to investigate the factors influencing the treatment of ultrashort chemotherapy for spinal tuberculosis. Methods from January 2004 to December 2013, 211 patients with spinal tuberculosis underwent surgical treatment in the Department of Spinal Orthopedics, Ningxia Medical University General Hospital. 120 patients (59 males and 61 females, aged 37.91 鹵16.71 years) underwent ultrashort chemotherapy, and 91 patients (47 males and 44 females, aged 43.67 鹵16.56 years) received ultrashort chemotherapy. The clinical data of the two groups were collected before and after operation, including initial treatment or relapse, age, whether other diseases were involved, whether other active tuberculosis was involved, whether anemia, involvement of lesions, abscess, and operative stages. Bone graft materials, complete clearance of lesions, bone grafting, drug resistance and other 12 aspects. Single factor logistic regression analysis was used to screen out the variables and then multivariate logistic regression analysis was carried out to speculate the factors that might influence the treatment of ultrashort chemotherapy after spinal tuberculosis operation. Results 120 cases of ultrashort chemotherapy group were followed up for 38 ~ 154 months (mean 90.11 鹵30.81 months), the course of chemotherapy was 3 ~ 6 months (mean 4.65 鹵0.98 months). The follow-up time was 45-153 months (mean 89.73 鹵28.08 months) and the course of chemotherapy was 6.5 ~ 34 months (mean 11.32 鹵5.30 months) in the non-ultrashort chemotherapy group. The results of univariate and multivariate logistic regression analysis showed that there were significant correlations among the three factors: complete debridement, bone grafting, and involvement level with the treatment of ultrashort chemotherapy (P0.05). Conclusion radical clearance and bone grafting are favorable factors for ultrashort chemotherapy, and multilevel involvement is the unfavorable factor for ultrashort chemotherapy.
【學(xué)位授予單位】：寧夏醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R687.3

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