本文選題：經(jīng)導(dǎo)管主動(dòng)脈瓣置入術(shù) + 標(biāo)準(zhǔn)療法��； 參考：《新疆醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:系統(tǒng)評(píng)價(jià)經(jīng)導(dǎo)管主動(dòng)脈瓣置入術(shù)(TAVI)與標(biāo)準(zhǔn)療法(藥物治療或經(jīng)皮球囊主動(dòng)脈瓣成形術(shù),ST)相比,治療老年重度主動(dòng)脈瓣狹窄(AS)患者的有效性和安全性。方法:檢索PubMed、EMbase、Cochrane Library、萬(wàn)方數(shù)據(jù)庫(kù)和中國(guó)知網(wǎng)數(shù)據(jù)庫(kù),自建庫(kù)時(shí)間至2016年9月發(fā)表的相關(guān)文獻(xiàn),同時(shí)檢索納入文章的參考文獻(xiàn)。按納入及排除標(biāo)準(zhǔn)篩選文獻(xiàn),提取納入文獻(xiàn)相關(guān)資料。應(yīng)用RevMan 5.3(Copenhagen:The Nordic Cochrane Centre,The Cochrane Collaboration,2013)軟件進(jìn)行數(shù)據(jù)分析。結(jié)果:共納入6項(xiàng)研究,包含1603例患者。Meta分析顯示,與ST相比,TAVI可以顯著降低患者6個(gè)月死亡率[風(fēng)險(xiǎn)比(RR)=0.51,95%可信區(qū)間(CI):0.39~0.66,P0.01]及12個(gè)月死亡率(RR=0.58,95%CI:0.48~0.71,P0.01)。但1個(gè)月死亡率無(wú)顯著統(tǒng)計(jì)學(xué)差異(RR=1.09,95%CI:0.73~1.64,P=0.67)。并且,TAVI術(shù)后1個(gè)月內(nèi)患者腦血管事件發(fā)生率(RR=4.24,95%CI:1.64~10.99,P0.01)及出血發(fā)生率(RR=3.75,95%CI:1.77~7.92,P0.01)均顯著增高。結(jié)論:經(jīng)導(dǎo)管主動(dòng)脈瓣置入術(shù)與標(biāo)準(zhǔn)療法相比,雖增高術(shù)后1個(gè)月內(nèi)腦血管事件及出血發(fā)生率,但可降低6個(gè)月及12個(gè)月死亡率。
[Abstract]:Objective: to evaluate the efficacy and safety of transcatheter aortic valve placement (tavi) in elderly patients with severe aortic valve stenosis (as) compared with standard therapy (drug therapy or percutaneous balloon aortic valvuloplasty St). Methods: the relevant literatures published from the time of establishment of the database were retrieved from the database of PubMedus EMbase Cochrane Library, Wanfang Database and China knowledge Network database, and the references of the articles were also searched at the same time. According to the inclusion and exclusion criteria to screen the literature, extraction and inclusion of literature related materials. Use RevMan 5.3 (Copenhagen: the Nordic Cochrane Centre, the Cochrane collaboration 2013) for data analysis. Results: a total of 6 studies including 1603 patients. Meta-analysis showed that compared with St, tavi significantly reduced 6-month mortality [risk ratio (RR) 0.51 95% confidence interval (CI) 0.390.390.66% P0.01] and 12-month mortality (RRV 0.588% 95% CI0.480.71P0.01). However, there was no significant difference in 1 month mortality (RRX 1.09 鹵95CI: 0.73% 1.64% P 0.67). The incidence of cerebrovascular events (RRX 4.2495 CI: 1.6410. 99% P0.01) and bleeding (RRV 3.75% 95% CIW 1.777.92% P0.01) were significantly increased within one month after TAVI. Conclusion: compared with the standard therapy, transcatheter aortic valve implantation can decrease the mortality of 6 months and 12 months, although it can increase the incidence of cerebrovascular events and hemorrhage within 1 month after operation.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R654.2

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相關(guān)期刊論文 前1條

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