本文選題：經(jīng)導管主動脈瓣置入術(shù) + 標準療法��； 參考：《新疆醫(yī)科大學》2017年碩士論文

【摘要】：目的:系統(tǒng)評價經(jīng)導管主動脈瓣置入術(shù)(TAVI)與標準療法(藥物治療或經(jīng)皮球囊主動脈瓣成形術(shù),ST)相比,治療老年重度主動脈瓣狹窄(AS)患者的有效性和安全性。方法:檢索PubMed、EMbase、Cochrane Library、萬方數(shù)據(jù)庫和中國知網(wǎng)數(shù)據(jù)庫,自建庫時間至2016年9月發(fā)表的相關(guān)文獻,同時檢索納入文章的參考文獻。按納入及排除標準篩選文獻,提取納入文獻相關(guān)資料。應(yīng)用RevMan 5.3(Copenhagen:The Nordic Cochrane Centre,The Cochrane Collaboration,2013)軟件進行數(shù)據(jù)分析。結(jié)果:共納入6項研究,包含1603例患者。Meta分析顯示,與ST相比,TAVI可以顯著降低患者6個月死亡率[風險比(RR)=0.51,95%可信區(qū)間(CI):0.39~0.66,P0.01]及12個月死亡率(RR=0.58,95%CI:0.48~0.71,P0.01)。但1個月死亡率無顯著統(tǒng)計學差異(RR=1.09,95%CI:0.73~1.64,P=0.67)。并且,TAVI術(shù)后1個月內(nèi)患者腦血管事件發(fā)生率(RR=4.24,95%CI:1.64~10.99,P0.01)及出血發(fā)生率(RR=3.75,95%CI:1.77~7.92,P0.01)均顯著增高。結(jié)論:經(jīng)導管主動脈瓣置入術(shù)與標準療法相比,雖增高術(shù)后1個月內(nèi)腦血管事件及出血發(fā)生率,但可降低6個月及12個月死亡率。
[Abstract]:Objective: to evaluate the efficacy and safety of transcatheter aortic valve placement (tavi) in elderly patients with severe aortic valve stenosis (as) compared with standard therapy (drug therapy or percutaneous balloon aortic valvuloplasty St). Methods: the relevant literatures published from the time of establishment of the database were retrieved from the database of PubMedus EMbase Cochrane Library, Wanfang Database and China knowledge Network database, and the references of the articles were also searched at the same time. According to the inclusion and exclusion criteria to screen the literature, extraction and inclusion of literature related materials. Use RevMan 5.3 (Copenhagen: the Nordic Cochrane Centre, the Cochrane collaboration 2013) for data analysis. Results: a total of 6 studies including 1603 patients. Meta-analysis showed that compared with St, tavi significantly reduced 6-month mortality [risk ratio (RR) 0.51 95% confidence interval (CI) 0.390.390.66% P0.01] and 12-month mortality (RRV 0.588% 95% CI0.480.71P0.01). However, there was no significant difference in 1 month mortality (RRX 1.09 鹵95CI: 0.73% 1.64% P 0.67). The incidence of cerebrovascular events (RRX 4.2495 CI: 1.6410. 99% P0.01) and bleeding (RRV 3.75% 95% CIW 1.777.92% P0.01) were significantly increased within one month after TAVI. Conclusion: compared with the standard therapy, transcatheter aortic valve implantation can decrease the mortality of 6 months and 12 months, although it can increase the incidence of cerebrovascular events and hemorrhage within 1 month after operation.
【學位授予單位】：新疆醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R654.2

【參考文獻】

相關(guān)期刊論文 前1條

1 葛均波;周達新;潘文志;王箴;葛雷;潘翠珍;羅紅;丁文軍;王春生;陳紀言;方唯一;傅國勝;霍勇;王偉民;張大東;;經(jīng)皮主動脈瓣植入術(shù)一例及其操作要點[J];中國介入心臟病學雜志;2010年05期

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