本文選題：丁苯酞氯化鈉注射液 + 鉆孔引流術��； 參考：《中國藥房》2017年26期

【摘要】：目的:探討丁苯酞氯化鈉注射液對老年高血壓性腦出血(HICH)鉆孔引流術治療后神經(jīng)功能及預后的影響。方法:選取2015年1月-2016年6月我院收治的老年HICH患者80例作為研究對象,按照隨機數(shù)字表法分為對照組和觀察組,各40例。兩組患者均接受鉆孔引流術治療,對照組患者術后給予常規(guī)治療;觀察組患者于術后第5天在對照組基礎上給予丁苯酞氯化鈉注射液100 mL,ivgtt,bid。兩組患者均治療14 d。觀察兩組患者臨床療效和兩組存活患者術前及術后28 d中國腦卒中臨床神經(jīng)功能缺損程度評分量表(CSS)評分,比較兩組患者術前及術后14 d腦水腫體積、血清同型半胱氨酸(HCY)和P物質(zhì)(SP)水平。結果:兩組患者各病死1例,觀察組患者臨床總有效率為87.5%,顯著高于對照組的67.5%,差異有統(tǒng)計學意義(P0.05)。術前,兩組存活患者CSS評分、腦水腫體積、血清HCY、SP水平比較,差異均無統(tǒng)計學意義(P0.05);術后28 d,兩組存活患者CSS評分顯著降低,術后14 d,兩組患者SP水平顯著升高,血清HCY水平顯著降低,腦水腫體積顯著縮小,且觀察組患者上述指標顯著優(yōu)于對照組,差異均有統(tǒng)計學意義(P0.05)。結論:丁苯酞氯化鈉注射液能顯著提高老年HICH患者鉆孔引流術后的臨床療效,改善神經(jīng)功能缺損,減輕術后腦水腫,并且能夠降低血清HCY水平,提高SP水平。
[Abstract]:Objective: to investigate the effect of butyphthalide sodium chloride injection on nerve function and prognosis in elderly patients with hypertensive intracerebral hemorrhage (HICH). Methods: 80 elderly HICH patients treated in our hospital from January 2015 to June 2016 were selected and divided into control group (n = 40) and observation group (n = 40). The patients in the two groups were treated with drilling and drainage, the patients in the control group were treated with routine treatment after operation, and the patients in the observation group were treated with 100 mL sodium phthalide chloride injection on the basis of the control group on the 5th day after operation. Both groups were treated for 14 days. To observe the clinical efficacy of the two groups and the scores of neurological deficit scale (CSS) before and 28 days after operation in the two groups, and to compare the volume of brain edema between the two groups before and 14 days after operation. Serum homocysteine (HCY) and substance P (SP) levels. Results: one patient died in each of the two groups. The total effective rate of the observation group was 87.5, which was significantly higher than that of the control group (P 0.05). Before operation, there was no significant difference in CSS score, cerebral edema volume and serum HCYN SP level between the two groups (P0.05), but at 28 days after operation, the CSS score of survival patients in both groups decreased significantly, and at 14 days after operation, the SP level of the two groups increased significantly. The level of serum HCY was significantly decreased and the volume of brain edema was significantly reduced. The above indexes in the observation group were significantly better than those in the control group (P0.05). Conclusion: butyphthalide sodium chloride injection can significantly improve the clinical effect after drilling and drainage in elderly patients with HICH, improve neurological function defect, reduce postoperative cerebral edema, and reduce serum HCY level and SP level.
【作者單位】： 漢中3201醫(yī)院神經(jīng)外科;延安大學醫(yī)學院生物化學與分子生物學教研室;延安市人民醫(yī)院神經(jīng)外科;
【分類號】：R651.12

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